Electrolyte repletion is a rather well-known task typically assigned to medicine and surgery interns on a patient’s primary team. The specifics surrounding dose and formulation are things you will quickly pick up on the job, but as a medical student it is probably more valuable to understand the importance of managing electrolytes, as well as the consequences of dysregulated electrolyte levels. In this episode we review exactly that, covering the ins and outs of potassium, magnesium, phosphorus, calcium, and sodium. If you have any qualms about handling electrolytes, let’s solve them now!