Brain Energy and Function, Improved with Glycine/NAC? Episode 1137 MAY 2023

The results of this study provide proof-of-concept that GlyNAC supplementation improves age-associated cognitive decline and supports brain health in aging by improving/correcting brain GSH deficiency, elevated OxS, mitochondrial dysfunction, abnormal mitophagy and autophagy, inflammation, impaired glucose transport/uptake, elevated genomic damage, and reversing the decline in brain neurotrophic growth factors. GlyNAC could be a simple and effective nutritional supplement to support brain health and cognitive function in aging, and warrants additional investigation.

#glynac #brainrespiration #cognition

Kumar, P., Osahon, O. W., & Sekhar, R. V. (2023). GlyNAC (Glycine and N-Acetylcysteine) Supplementation in Old Mice Improves Brain Glutathione Deficiency, Oxidative Stress, Glucose Uptake, Mitochondrial Dysfunction, Genomic Damage, Inflammation and Neurotrophic Factors to Reverse Age-Associated Cognitive Decline: Implications for Improving Brain Health in Aging. Antioxidants, 12(5), 1042. https://doi.org/10.3390/antiox12051042

Glynac, glycine, N-Acetylcysteine, correction, GSH Synthesis , cognitive improvement, brain health, GSH, OxS, mitochondrial energetics, autophagy/mitophagy, glucose transporters, inflammation, genomic damage, neurotrophic factors

Brain Energy and Function, Improved with Glycine/NAC? Episode 1137 MAY 2023 #glynac #glycine #nacetylcysteine #brain #aging #brainheath #stem

Testosterone And Enokitake Mushroom Show 1135 MAY 2023

This study showed that the ingestion of adenosine-containing mushrooms and vegetables may effectively increase testicular testosterone production. We conclude that mushrooms with a relatively high adenosine content, such as enokitake, may be useful against aging and fatigue.

#enokitake #testosterone #leydig

Iguchi, K., Nagashima, K., Mochizuki, J., Yamamoto, H., Unno, K., & Miyoshi, N. (2023). Enokitake Mushroom and Its Active Component, Adenosine, Which Restores Testosterone Production in Impaired and Fatigued Mouse Models. Nutrients, 15(9), 2142. https://doi.org/10.3390/nu15092142

Adenosine, enokitake mushroom, enoki, testosterone, male menopause, mushrooms, Leydig cells, polyphenols, Flammulina velutipes. Golden needle, winter mushroom, fatigue, anti aging,

Testosterone And Enokitake Mushroom Show 1135 MAY 2023

This study showed that the ingestion of adenosine-containing mushrooms and vegetables may effectively increase testicular testosterone production. We conclude that mushrooms with a relatively high adenosine content, such as enokitake, may be useful against aging and fatigue.

#enokitake #testosterone #leydig

Iguchi, K., Nagashima, K., Mochizuki, J., Yamamoto, H., Unno, K., & Miyoshi, N. (2023). Enokitake Mushroom and Its Active Component, Adenosine, Which Restores Testosterone Production in Impaired and Fatigued Mouse Models. Nutrients, 15(9), 2142. https://doi.org/10.3390/nu15092142

Adenosine, enokitake mushroom, enoki, testosterone, male menopause, mushrooms, Leydig cells, polyphenols, Flammulina velutipes. Golden needle, winter mushroom, fatigue, anti aging,

Inhaled ethanol may treat respiratory infections and stop pandemics

The scientists think that the ethanol vapor must increase ethanol concentrations in the fluid to 20% to successfully treat the infection. This concentration is not toxic to lung cells the scientists created in the lab to mimic human cells. At body temperature, 20% ethanol can not only inactivate the influenza A virus outside of the cells in one minute, but also stop the virus from replicating inside these cells.

Tamai, M., Taba, S., Mise, T., Yamashita, M., Ishikawa, H., & Shintake, T. Effect of Ethanol Vapor Inhalation Treatment on Lethal Respiratory Viral Infection With Influenza A. The Journal of Infectious Diseases. https://doi.org/10.1093/infdis/jiad089

Influenza A virus, ethanol, Influenza , Avian Flu, Sars COV 2, coronavirus, inhalation, enveloped virus, etoh vapor, progeny virus, respiratory infections, severe acute respiratory syndrome coronavirus 2

The scientists think that the ethanol vapor must increase ethanol concentrations in the fluid to 20% to successfully treat the infection. This concentration is not toxic to lung cells the scientists created in the lab to mimic human cells. At body temperature, 20% ethanol can not only inactivate the influenza A virus outside of the cells in one minute, but also stop the virus from replicating inside these cells.

Tamai, M., Taba, S., Mise, T., Yamashita, M., Ishikawa, H., & Shintake, T. Effect of Ethanol Vapor Inhalation Treatment on Lethal Respiratory Viral Infection With Influenza A. The Journal of Infectious Diseases. https://doi.org/10.1093/infdis/jiad089

Influenza A virus, ethanol, Influenza , Avian Flu, Sars COV 2, coronavirus, inhalation, enveloped virus, etoh vapor, progeny virus, respiratory infections, severe acute respiratory syndrome coronavirus 2

"Remarkably, the cognitive scores increased to levels similar to undergraduates taking the same cognitive tests for the first time," Wu said. "Our finding of continuous cognitive growth in older adulthood is unique because most studies show only maintenance of cognitive abilities or cognitive decline over time."

Leah Ferguson, Debaleena Sain, Esra Kürüm, Carla M. Strickland-Hughes, George W. Rebok, Rachel Wu. One-year cognitive outcomes from a multiple real-world skill learning intervention with older adults. Aging & Mental Health, 2023; 1 DOI: 10.1080/13607863.2023.2197847

#brain #cognitive #aging

Musical expertise makes older adults better listeners by keeping brain young

"Playing music makes older adults better listeners by preserving youthful neural patterns as well as recruiting additional compensatory brain regions. Our study provides empirical evidence to support that playing music keeps your brain sharp, young, and focused,” said Dr. DU, corresponding author of this study.

Zhang, L., Wang, X., Alain, C., & Du, Y. (2023). Successful aging of musicians: Preservation of sensorimotor regions aids audiovisual speech-in-noise perception. Science Advances. https://doi.org/adg7056

Cognition, learning, DMN, frontoparietal, cognitive control, working memory, episodic memory, default mode network, continuous cognitive growth, successful aging, youthful brain, dementia, Alzheimers, speech processing, reverse aging brain, improve brain function, older learners

Older Brains learn to Outperform Younger Ones #aging #successfulaging #brain #cognition #memory #learning #stem #DMN #workingmemory #episodicmemory

"Remarkably, the cognitive scores increased to levels similar to undergraduates taking the same cognitive tests for the first time," Wu said. "Our finding of continuous cognitive growth in older adulthood is unique because most studies show only maintenance of cognitive abilities or cognitive decline over time."

Leah Ferguson, Debaleena Sain, Esra Kürüm, Carla M. Strickland-Hughes, George W. Rebok, Rachel Wu. One-year cognitive outcomes from a multiple real-world skill learning intervention with older adults. Aging & Mental Health, 2023; 1 DOI: 10.1080/13607863.2023.2197847

#brain #cognitive #aging

Musical expertise makes older adults better listeners by keeping brain young

"Playing music makes older adults better listeners by preserving youthful neural patterns as well as recruiting additional compensatory brain regions. Our study provides empirical evidence to support that playing music keeps your brain sharp, young, and focused,” said Dr. DU, corresponding author of this study.

Zhang, L., Wang, X., Alain, C., & Du, Y. (2023). Successful aging of musicians: Preservation of sensorimotor regions aids audiovisual speech-in-noise perception. Science Advances. https://doi.org/adg7056

Cognition, learning, DMN, frontoparietal, cognitive control, working memory, episodic memory, default mode network, continuous cognitive growth, successful aging, youthful brain, dementia, Alzheimers, speech processing, reverse aging brain, improve brain function, older learners

Older Brains learn to Outperform Younger Ones #aging #successfulaging #brain #cognition #memory #learning #stem #DMN #workingmemory #episodicmemory

In summary, this RCT, evaluating the functionality of daily consumption of flaxseed oil containing 2.2 g of ALA, improved verbal fluency in healthy individuals aged between 65 to 80 years, with no abnormalities in cognitive function, despite declines with age. Since the improvement in verbal fluency is significant in cognitive health, as it is one of the factors of Alzheimer’s disease progress [37], further validation studies, with a focus on ALA’s impact on verbal fluency and executive function, are needed to extend the obtained evidence in this study to older adults.

Ogawa, T., Sawane, K., Ookoshi, K., & Kawashima, R. (2023). Supplementation with Flaxseed Oil Rich in Alpha-Linolenic Acid Improves Verbal Fluency in Healthy Older Adults. Nutrients, 15(6), 1499. https://doi.org/10.3390/nu15061499

#flaxseedoil #verbalfluency #executivefunction

Ala, cognitive function, age, flax seed oil, executive function, Alzheimer’s , verbal fluency, dha, alpha linolenic acid, docosahexaenoic acid

Flax Seed Oil Brain Function Verbal Fluency #flaxseedoil #verbalfluency #stem #cognitivefunctions #ala #alphalinolenicacid #dha #docosahexaenoicacid #agingwell Ogawa, T., Sawane, K., Ookoshi, K., & Kawashima, R. (2023). Supplementation with Flaxseed Oil Rich in Alpha-Linolenic Acid Improves Verbal Fluency in Healthy Older Adults.

In summary, this RCT, evaluating the functionality of daily

Ogawa, T., Sawane, K., Ookoshi, K., & Kawashima, R.

#flaxseedoil #verbalfluency #executivefunction

Ala, cognitive function, age, flax seed oil, executive

Flax Seed Oil Brain Function Verbal Fluency #flaxseedoil

There was a statistically significant (p=.039) difference in the participants' mean biological age before (55.83 years) and after (51.23 years) the 8-week diet and lifestyle intervention, with an average decrease of 4.60 years. The average chronological age at the start of the program was 57.9 years and all but one participant had a biological age younger than their chronological age at the start of the program, suggesting that biological age changes were unrelated to disease improvement and instead might be attributed to underlying aging mechanisms.

#agereversal #methylationdiet #biologicalage

Fitzgerald KN, Campbell T, Makarem S, Hodges R. Potential reversal of biological age in women following an 8-week methylation-supportive diet and lifestyle program: a case series. Aging (Albany NY). 2023 Mar 22; 15:1833-1839 . https://doi.org/10.18632/aging.204602

DNA methylation, age reversal, biological age, health span, life span, longevity, polyphenolic modulators of DNA methyl transferase, ten-eleven translocation (TET) demethylase cofactors, DMNT, a methylation-supportive diet, epinutrients, curcumin, epigallocatechin gallate (EGCG), rosmarinic acid, quercetin, luteolin