When counseling the parents of a 7-year-old patient regarding pharmacotherapy for attention deficit disorder, the PMHNP identifies which clinically relevant difference between clonidine and guanfacine?

A. Guanfacine may be used as adjunct therapy to psychostimulants.

B. Clonidine is available in a long-acting formulation.

C. Clonidine is selective for alpha-2a adrenergic receptors.

D. Guanfacine is appreciably less sedating.
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