My guest today is Jamie Metzl—a former national security official, biotech futurist, and one of the earliest public voices to argue that Covid likely came from a lab accident. We talk about why that possibility became taboo; what gain-of-function research gets wrong; and how fear and politics distort scientific judgment. From there, we move into the future of gene editing, embryo selection, genetically modified organisms (GMOs), and artificial intelligence (AI)—what’s actually coming, what people misunderstand, and why the hardest questions ahead of us aren’t likely technical, but moral.

https://jamiemetzl.com/human-genetic-engineering-and-the-catholic-church/

Learn more about your ad choices. Visit megaphone.fm/adchoices

My guest today is Rabbi David Wolpe. He’s spent decades debating atheists, leading one of the country’s largest synagogues, and thinking seriously about what holds a moral society together once traditional faith loosens its grip. Wolpe and I talk about belief after the New Atheists, why reason alone keeps overreaching, and how secular movements quietly take on the structure—and zeal—of religion. We get into Judaism as a form of peoplehood, the strange moral logic of modern campus activism, antisemitism as a conspiracy engine, and why slogans and ideology can harden into dogma. Wolpe also reflects on his time teaching at Harvard, the limits of academic tolerance, and what he learned about institutions under pressure. 

Learn more about your ad choices. Visit megaphone.fm/adchoices

This week I spoke to Arctic geopolitics expert Heather A. Conley, before President Trump made a speech at The World Economic Forum in Davos on Wednesday. Heather spoke to me about a place most of us barely think about—until it becomes the center of a global power struggle. Greenland has gone from frozen afterthought to geopolitical prize, and its story reveals a lot about American expansionism, NATO politics, and the race now unfolding in the Arctic. We trace Greenland’s strange political history with Denmark and the U.S., unpack why its location has always mattered militarily, and explore what happens as China and Russia push north. We also confront the uncomfortable truth behind Trump’s “buy Greenland” moment—and why the people who actually live there want neither Denmark nor America to own them.

Learn more about your ad choices. Visit megaphone.fm/adchoices

In a world where AI can recreate our voices, half the internet thinks the moon landing was staged, and every group chat has a cousin who’s “just asking questions,” the perceived line between fact and fantasy has never been blurrier.

On February 9 at the Comedy Cellar in NYC, Coleman Hughes will sit down with Michael Shermer—historian of science and author of Truth: What It Is, How to Find It & Why It Still Matters—for a live conversation. Together they’ll dig into why smart people believe strange things—from conspiracy theories and moral panics to post-truth politics—and how skepticism, evidence, and reason can still help us figure out what’s actually real. Is truth the only antidote to our world of cynicism and confusion?

After the conversation, we’ll head to a nearby bar for an informal meetup with Michael, Coleman, and fellow Free Pressers for drinks, discussion, and the rare pleasure of arguing in good faith. (Location will be shared with ticket holders only.)

This New York City event is intentionally intimate and will sell out quickly. Don’t delay.

---

February 9, 2026

6:00pm1

Comedy Cellar @ 30 West 3rd Street, NY, NY, 10012 

---

Tickets are here.

Learn more about your ad choices. Visit megaphone.fm/adchoices

This week I’m joined by historian Niall Ferguson to help me make sense of Iran’s unprecedented wave of protests. We talk about why this moment feels different to previous uprisings, the regime’s growing crisis of legitimacy, the limits of sanctions, and how the long shadow of 1953 still shapes everything in Iran. We also look at what Trump’s “maximum pressure” could mean, and the risks posed by any form of U.S. intervention.

Learn more about your ad choices. Visit megaphone.fm/adchoices

Thor Halvorssen is a Venezuelan-born human rights campaigner and the founder of the Human Rights Foundation. His life as an activist began after his mother was shot and wounded by pro-regime forces for trying to expose election fraud under Hugo Chávez, an event that turned his work from theory into something painfully concrete.

In this episode we talk about how Venezuela’s dictatorship operated more like a cartel than a state, why the regime survived despite losing elections, and how oil, narcotics, and foreign alliances sustained one of the worst humanitarian disasters in the hemisphere. We also discuss why Venezuela is not another Iraq, how major Western media outlets repeatedly misread the regime, and what a realistic political transition might look like.

Learn more about your ad choices. Visit megaphone.fm/adchoices

I’m joined by Gelet Martínez Fragela, a Cuban activist and journalist and a close watcher of Venezuela who’s tracked how authoritarianism hollowed out a once prosperous country.

We talk about the warning signs, the lies that sustained the regime, and why President Maduro’s trial in the United States matters far beyond Venezuelan borders. Gelet also answers the question: Why were Cubans responsible for guarding President Maduro? And how will the country function in the wake of the U.S.’s shock intervention?

For Gelet’s personal story, listen to our episode from October: https://podcasts.apple.com/us/podcast/inside-cubas-police-state-from-ration-cards-to-black/id1716338488?i=1000733663296

Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. Anna Machin is a British evolutionary anthropologist at the University of Oxford who studies the neuroscience and psychology of love. Anna and I talk through what science actually says about attraction, attachment, and long-term relationships, and why so much modern dating advice gets human nature wrong. We get into dating apps and how they shape behavior, whether love at first sight is real, what attachment styles do and don’t explain, and what science says about polyamory. We also discuss common myths about pheromones, love languages, and whether having kids really makes people happier.

Learn more about your ad choices. Visit megaphone.fm/adchoices

My producer Poppy Damon and I are back for another Ask Me Anything. In this bonus episode, I answer your questions on President Donald Trump and the attention economy, declining birth rates, psychedelics and mental health, AI and the future of work, social media and kids, religion, meritocracy, and more. 

As 2025 wraps up, it felt like a good moment to step back, take stock, and talk through the questions many of you have been thinking about. Thanks for listening this year—and here’s to more Conversations like this one in the year ahead.

Learn more about your ad choices. Visit megaphone.fm/adchoices

Tim Miller is a political commentator and former GOP strategist who became one of the most outspoken “‘Never Trump”’ conservatives in the country. Tim and I talk through the Republican Party’s transformation, from the guardrails John McCain tried to hold in place, to the anger and conspiratorial thinking that helped fuel Donald Trump’s rise. We get into what it was like to be an openly gay Republican in the 2000s, why Trump’s favorability is collapsing, and the administration’s bizarre new policy of blowing up alleged drug boats in the Caribbean. I also ask him about his recent interview with journalist Olivia Nuzzi and more. 

Bundle FOX One and FOX Nation to stream the entire FOX Nation library, plus live Sports and Entertainment at our lowest price of the year.

Learn more about your ad choices. Visit megaphone.fm/adchoices