Asger Granfeldt & Lars Wiuff Andersen (Aarhus, Denmark) present the results of the VAM-IHCA trial, investigating the combination of vasopressin and methylprednisolone for in-hospital cardiac arrest. This trial result was presented at a Critical Care Reviews Trial Results Livestream, on September 29th, 2021.

Prof Alistair Nichol (Dublin & Melbourne) discusses why the REMAP-CAP adaptive platform trial has chosen to investigate ivermectin, given the controversy surrounding this agent.

Dr Lennie Derde is the Trial Steering Committee Chair and the European Coordinating Investigator for the REMAP-CAP project. She discusses the running of the REMAP-CAP trial, her background in critical care and infectious diseases, how she got into critical care research, the background of the REMAP-CAP trial and its current workload for her. We also review the output from the trial to date and finish by considering how this pandemic is likely to progress.

BaSICS trial leads Drs Fernando Zampieri & Alexandre Biasi Cavalcante join Rob Mac Sweeney to address some of the questions and comments that arose following the presentation and publication of the BaSICS trial results.

Niklas Nielsen, the chief investigator for the TTM2 trial, joins Rob Mac Sweeney to address some of the questions and comments that arose following the presentation and publication of the TTM2 trial results.

Prof Manu Shankar-Hari, the lead for the WHO REACT group's prospective meta analysis on interleukin 6 antagonism in patients hospitalised with COVID-19, joins Rob Mac Sweeney to discuss this important work

Prof Giuseppe Citerio (Milan) joins Rob Mac Sweeney to discuss  the global SYNAPSE-ICU study, investigating the use of intracranial pressure monitoring in acute brain injury.

Phil Gillen (Belfast) asks questions posed by the viewers of the TTM2 results livestream to the TTM2 trialists Niklas Nielsen, Josef Dankiewicz and Gisela Lilja.

Niklas Nielsen, Josef Dankiewicz and Gisela Lilja (all Lund) presents the results of the landmark TTM2 trial, comparing hypothermia (33°) with normothermia (<37.8°) in 1850 comatose survivors of out-of-hospital cardiac arrest.

Panellists Jerry Nolan, Kathy Rowan and Terri Hough join editorialist Stephen Bernard and TTM2 investigators Niklas Nielsen, Josef Dankiewicz and Gisela Lilja to discuss the landmark TTM2 trial at the Critical Care Reviews hosted TTM2 results livestream.