Data Day with Greg Michaelson

Data Day with Greg Michaelson

By Greg MichaelsonBusinessTechnology
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Data Day with Greg Michaelson episodes

  • William Morgan and The Future of AI Infrastructure: Kubernetes, Open Models & What Comes Next

    William Morgan, founder and CEO of Buoyant and creator of Linkerd, joins Greg Michaelson to talk about how modern software infrastructure is changing in the age of AI.

    William breaks down Kubernetes and service meshes in plain English, shares lessons from helping scale Twitter during its early years, and explains why Buoyant built Linkerd as an open-source project.

    They also dig into how AI is changing software development, where AI-generated code can—and absolutely cannot—be trusted, and why the next major shift may be companies running powerful open-weight AI models inside their own infrastructure rather than relying entirely on external model providers.

    Topics include Kubernetes, Linkerd, service meshes, platform engineering, open-source business models, AI-assisted coding, local AI inference, open-weight models, GPUs, and the future of enterprise AI infrastructure.

    44 min
  • Chris Nyhuis - Inside the Mind of a Cyber Defender

    Most cyberattacks never make the news—but they happen every day. In this episode, Greg Michaelson sits down with Chris Nyhuis, CEO of Vigilant, to explore how modern attackers infiltrate organizations, why most companies don't detect breaches for months, and how Vigilant has reduced that window to just four hours. They discuss supply chain attacks, AI-powered cybersecurity, critical infrastructure, ransomware myths, protecting your home network, and Chris's remarkable work fighting human trafficking through technology.

    49 min
  • Derek Crager: Why AI Should Think With People, Not Replace Them

    In this episode, Greg sits down with Derek Crager, founder of Practical AI and creator of the Human-First AI philosophy. Derek shares his journey from industrial construction to Amazon, where he built the company's highest-rated employee training program and helped reduce technician attrition from over 80% to around 30%. The conversation explores why most enterprise AI initiatives fail, how voice-based AI mentors can preserve critical workforce knowledge, why specialized AI models outperform general-purpose chatbots for many tasks, and what it really means for AI to augment—not replace—human expertise.

    42 min
  • Yagub Rahimov - Securing the Age of AI

    Greg Michaelson sits down with Yagub Rahimov, founder and CEO of Polygraph AI, to explore the emerging field of AI security. They discuss why traditional cybersecurity is breaking down in the age of large language models, how Polygraph uses specialized small language models (SLMs) to monitor both human and AI behavior in real time, and why contextual security—not pattern matching—is the future. The conversation also covers prompt injection, data sovereignty, enterprise AI adoption, edge computing, and what every CISO should be thinking about as AI agents become part of the workforce.

    55 min
  • Rob Zuber - The Future of Software Engineering in the Age of AI Agents

    In this episode of Day Today, Greg Michaelson sits down with Rob Zuber, CTO of CircleCI, for a wide-ranging conversation about software engineering, developer tools, AI coding agents, and the future of building software.

    Rob shares his journey from manufacturing engineering and factory-floor data analysis to leading one of the most influential companies in modern software delivery. Along the way, he discusses the evolution of CI/CD, lessons from the dot-com era, and why today's AI boom feels both familiar and fundamentally different.

    Topics include:

    • The origins and evolution of CircleCI
    • Why speed and feedback loops remain the core of software delivery
    • How engineering teams are using AI coding agents like Claude Code and Codex
    • Managing token costs and AI infrastructure at scale
    • The changing role of IDEs, terminals, and developer interfaces
    • Agent experience (AX) and designing products for both humans and AI systems
    • Fine-tuning models versus large-context workflows
    • The future of code reviews, pull requests, and automated validation
    • What software engineering organizations will look like as AI-generated code becomes the norm

    Rob also explores a provocative question: if AI can write code, can we eventually trust systems enough that humans no longer need to review every line? The discussion offers a thoughtful look at where software development is headed and the challenges engineering teams must solve next.

    Whether you're a software engineer, engineering leader, startup founder, or AI enthusiast, this conversation provides valuable insight into the technologies and workflows reshaping the future of software development.

    56 min
  • Raheem Bell - Building the Autonomous Operating Room

    Raheem Bell is a surgical resident at Northwestern and the CEO of Operative Insights, a startup developing an autonomous operating room lighting system designed to help surgeons see better, work more efficiently, and improve patient outcomes. In this episode, Raheem shares how years in the operating room led him to identify a surprisingly common problem: surgeons constantly adjusting lights during procedures. We discuss how computer vision, robotics, and AI can be used to create intelligent lighting that follows the surgical team, eliminates shadows, and adapts to the needs of each operation. Raheem also talks about the challenges of building a medical device startup, navigating FDA approval, raising capital, assembling a multidisciplinary team, and balancing entrepreneurship with the demands of surgical training. It's a fascinating look at how innovation often starts with a simple frustration and grows into a mission to transform an entire industry. 

    37 min
  • Tony Medrano - AI, Peptides, and the Future of Personalized Longevity

    In this episode of Data Day with Greg Michaelson, Greg sits down with Tony Medrano to explore the rapidly evolving intersection of AI, wearable health data, peptides, and personalized longevity optimization.

    Tony shares his journey from founding one of the earliest AI startups in 2016 to helping scale a molecular diagnostics company from zero to $1 billion in revenue during the COVID era, serving organizations like NASA, Google, the NFL, and the NBA. 

    The conversation dives deep into:

    • What peptides actually are and how they work
    • The science behind compounds like BPC-157, GHK-CU, MOTS-c, and tesamorelin
    • AI-driven “digital twin” health optimization
    • Wearables, HRV tracking, and personalized biometric analysis
    • The difference between supplements, peptides, and pharmaceutical drugs
    • Longevity strategies for athletes, executives, and people over 40
    • Why most longevity advice online is noisy, biased, or incomplete
    • The future of AI-powered health coaching and preventative medicine

    Tony also explains how Longevity Plan AI combines wearable data, peptide protocols, physician oversight, and AI modeling to create personalized health optimization plans designed to improve recovery, metabolic health, energy, sleep, and performance. 

    If you’re interested in biohacking, longevity, AI-driven healthcare, performance optimization, or the future of personalized medicine, this episode is packed with fascinating insights and practical discussion.

    46 min
  • John Kane - Building AI Trading Systems for Sports Prediction Markets

    In this episode of Data Day with Greg Michaelson, Greg sits down with John Kane to explore the rapidly growing world of sports prediction markets and the AI systems powering next-generation quantitative trading.

    John explains how his company, Lazy Edge, applies quantitative finance techniques to live sports trading, using massive real-time data streams, simulation engines, and AI-driven modeling to identify market inefficiencies during games as they unfold.

    The conversation dives into:

    • How prediction markets like Polymarket and Kalshi actually work
    • Why live sports trading resembles quantitative stock trading more than gambling
    • Using simulations, AI agents, and “digital twins” to model game outcomes
    • Real-time NBA event prediction and market movement analysis
    • How bots trade sports markets automatically through APIs
    • The future of prediction markets, regulation, and AI-driven trading systems
    • Why chaos modeling matters in live game forecasting

    John also shares how tools like Zerve help accelerate experimentation and backtesting by allowing rapid iteration on complex predictive models and simulations.

    If you’re interested in AI, quantitative finance, trading systems, simulation modeling, or the intersection of sports and machine learning, this episode is a fascinating look at a space that’s evolving incredibly fast.

    37 min
  • Gaurav Jain - Developer Intent in the Age of AI Agents

    In this episode of Data Day with Greg Michaelson, Greg sits down with Gaurav Jain to explore one of the hardest problems in modern developer tooling: understanding developer intent. They dive into how technical buyers actually evaluate products, why traditional B2B funnels break down when selling to engineers, and how reo.dev tracks developer behavior across GitHub, docs, package managers, MCPs, and AI agents to help companies understand when users are truly ready to engage. The conversation also explores the rise of agent-driven discovery, the decline of documentation traffic, MCPs as the future interface layer for AI systems, and what happens when developers stop browsing websites and start delegating research to AI. 

    42 min
  • Tom Coyle - From CIA Operations to AI-Powered Cancer Care

    Tom Coyle’s career path sounds fictional until you realize it’s all true. West Point graduate, Army officer, CIA operations specialist, AI strategist, startup founder, and now health tech entrepreneur focused on improving cancer outcomes through nutrition and data.

    In this episode, Tom shares stories from his time tracking enemy mortar patterns in military simulations, helping intelligence teams think differently about finding Osama bin Laden, and eventually joining DataRobot during the rise of enterprise AI. He explains how pattern recognition, predictive analytics, and human behavior shaped his career long before modern AI tools existed.

    We also dive deep into his current company, Science Cella, an AI-driven nutrition platform designed to help cancer patients manage symptoms, improve treatment outcomes, and give dieticians scalable tools for personalized care. Tom talks candidly about surviving cancer himself, the realities of healthcare innovation, startup fundraising, clinical trials, and why he believes “food as medicine” deserves serious scientific validation.

    This conversation covers military technology, intelligence work, AI, startups, healthcare, nutrition, entrepreneurship, and the lessons learned from building products in high-stakes environments.

    47 min

About Data Day with Greg Michaelson

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DataDay with Greg Michaelson is a podcast about the real lives of people who work with data and AI every day. Not the polished conference-talk version, but the messy, clever, practical, human…