Deep Breaths: Updates from CHEST

Despite triple inhaled therapy, many patients with chronic obstructive pulmonary disease (COPD) continue to experience frequent and severe exacerbations, leading to hospitalizations, symptom burden, and higher mortality risk. In this expert-led discussion, Drs. Diego Maselli and Stephanie Christenson personalized treatment approaches and the role of biologics in advanced COPD care. Dr. Maselli is a Professor of Medicine at the Long School of Medicine at UT Health San Antonio, and Dr. Christenson is an Associate Professor in the Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine and an attending physician on the Pulmonary Consult Service and in the Pulmonary Clinic at the University of California in San Francisco.

This program is produced in partnership with the American College of Chest Physicians and is sponsored by Sanofi and Regeneron Pharmaceuticals, Inc.

New strategies like advanced pharmacologic agents and bronchoscopic lung volume reduction are redefining COPD and emphysema management. Dr. Bobby Mahajan sits down with Drs. Surya Bhatt and Jonathan Kurman to highlight emerging strategies for identifying ideal candidates, optimizing patient selection, and combining therapies to reduce dyspnea and improve outcomes. Dr. Mahajan is the Medical Director of Interventional Pulmonology and Complex Airway Disease Programs at the Inova Health System in Virginia, Dr. Bhatt is the Director of the Center for Lung Analytics and Imaging Research as well as the Medical Director of the Pulmonary Function and Exercise Physiology Lab and the Pulmonary Rehabilitation Program at the University of Alabama at Birmingham, and Dr. Kurman is an Associate Professor of Medicine at the Medical College of Wisconsin and the Director of Interventional Pulmonology at Froedtert and Medical College of Wisconsin Health Network.

This program is produced in partnership with the American College of Chest Physicians and is sponsored by Pulmonx, the maker of the Zephyr Valve.

Recent data from ASCO and ASTRO 2025 are redefining standards of care for resectable non-small cell lung cancer (NSCLC). Drs. Gerard Silvestri, Mariam Alexander, Anurag Singh, and Jessica Donington review these updates on the importance of molecular testing, careful surgical selection, and multidisciplinary planning to optimize personalized treatment pathways. Dr. Silvestri is a pulmonologist and the Hillenbrand Professor of Thoracic Oncology at the Medical University of South Carolina; Dr. Alexander is an Assistant Professor of Medical Oncology at the Medical University of South Carolina; Dr. Singh is the Director of Radiation Research, Director of Head and Neck and Lymphoma Radiation Services, and the Associate Dean of Graduate Medical Education in Radiation Medicine at Roswell Park Comprehensive Cancer Center in Buffalo, New York; and Dr. Donington is a Professor of Surgery and Chief of the Section of Thoracic Surgery at the University of Chicago.

This program is produced in partnership with the American College of Chest Physicians and is sponsored by AstraZeneca.

Effective care for non-small cell lung cancer (NSCLC) now depends on early molecular testing and coordinated input from a variety of specialties. Dr. Gerard Silvestri sits down with Drs. Jessica Donington, Mariam Alexander, and Anurag Singh to review why multidisciplinary integration is critical to avoid treatment delays, ensure appropriate therapy selection, and ultimately improve patient outcomes. Dr. Silvestri is a pulmonologist and the Hillenbrand Professor of Thoracic Oncology at the Medical University of South Carolina; Dr. Donington is a Professor of Surgery and Chief of the Section of Thoracic Surgery at the University of Chicago; Dr. Alexander is an Assistant Professor of Medicine and Medical Oncology at the Medical University of South Carolina; and Dr. Singh is the Director of Radiation Research, Director of the Head and Neck and Lymphoma Radiation Services, and the Associate Dean of Graduate Medical Education in Radiation Medicine at Roswell Park Comprehensive Cancer Center in Buffalo, New York.

This program is produced in partnership with the American College of Chest Physicians and is sponsored by AstraZeneca.

Refractory chronic cough (RCC) is a debilitating condition that is often misunderstood and underdiagnosed, leaving patients with persistent symptoms despite standard treatment. Hear from Drs. Michael Ghobrial, Anju Peters, and Michael Blaiss as they clarify the definition of RCC, outline essential diagnostic steps, and review current and emerging management strategies. Dr. Ghobrial is the Director of the Chronic Cough Clinic at Cleveland Clinic; Dr. Peters is a Professor of Medicine and Associate Chief of Clinical Research and Practice and Operation in the Division of Allergy and Immunology at Northwestern Medicine; and Dr. Blaiss is a Clinical Professor of Pediatrics at the Medical College of Georgia and an allergist at Good Samaritan Health Center of Gwinnett.

This episode is a non-promotional, non-CME educational program brought to you by CHEST in collaboration with GSK.

Refractory chronic cough can persist for years despite guideline-based therapy, significantly affecting patients’ physical, social, and psychological wellbeing. Leading experts Drs. Michael Ghobrial, Anju Peters, and Michael Blaiss explain how to distinguish RCC from other types of chronic cough, outline effective diagnostic strategies, and explore emerging treatment options. Dr. Ghobrial is the Director of the Chronic Cough Clinic at Cleveland Clinic; Dr. Peters is a Professor of Medicine and the Associate Chief of Clinical Research and Practice Innovation in the Division of Allergy and Immunology at Northwestern Medicine; and Dr. Blaiss is a Clinical Professor of Pediatrics at the Medical College of Georgia and an allergist at Good Samaritan Health Center of Gwinnett.

This episode is a non-promotional, non-CME educational program brought to you by CHEST in collaboration with GSK.

Effectively supporting patients with interstitial lung disease (ILD) requires more than just clinical knowledge—it demands strong, trust-based communication from the very first moments spent with a patient. Dr. Susan Corbridge sits down with Drs. Brad Bemiss and Debasree Banerjee to explore how the American College of Chest Physicians (CHEST)’s First 5 Minutes framework can help validate patient concerns, reduce fear, and establish a collaborative care plan from the beginning. Dr. Corbridge is a Professor Emerita at the University of Illinois Chicago College of Nursing; Dr. Bemiss is an Associate Professor of Pulmonary and Critical Care in the Department of Medicine and the Director of the Interstitial Lung Disease Program at Northwestern University; and Dr. Banerjee is an Associate Professor of Medicine in the Division of Pulmonary, Critical Care, and Sleep Medicine and an Associate Medical Director of the MICU at Brown University.

This episode is a non-promotional, non-CME educational program brought to you by CHEST in collaboration with Boehringer Ingelheim.

Cutting-edge biopsy methods and streamlined biomarker testing are transforming early-stage non-small cell lung cancer (NSCLC) care. Hear from Drs. Gerard Silvestri, Fabien Maldonado, and Adam Fox as they discuss the evolution of bronchoscopic techniques, insights from landmark trials, and the role of pragmatic clinical research in refining biopsy approaches. Dr. Silvestri is a pulmonologist and the Hillenbrand Professor of Thoracic Oncology at the Medical University of South Carolina; Dr. Maldonado is a Professor of Medicine and Thoracic Surgery, the Pierre Massion Director in Lung Cancer Research, and the Director of Interventional Pulmonology Research at Vanderbilt University; and Dr. Fox is a pulmonologist and Assistant Professor of Medicine at the Medical University of South Carolina.

This program is produced in partnership with the American College of Chest Physicians and is sponsored by AstraZeneca.

For patients with non-small cell lung cancer, staging accuracy is critical in guiding treatment decisions that can significantly affect outcomes. In this expert-led discussion, Dr. Gerard Silvestri sits down with Drs. Anne Gonzalez and Jeffrey Velotta break down what clinicians need to know, including how to perform thorough EBUS staging, why PET scans alone aren’t enough, and what the updated TNM classification means for surgical planning. Dr. Silvestri is a pulmonologist and the Hillenbrand Professor of Thoracic Oncology at the Medical University of South Carolina; Dr. Gonzalez is a pulmonary and critical care physician, a researcher in the Translational Research and Respiratory Diseases Program, and an Associate Professor in the Department of Medicine at McGill University in Montreal; and Dr. Velotta is a leading thoracic surgeon specializing in complex cancers, a Clinical Professor in the Department of Clinical Science at the Kaiser Permanente Bernard J. Tyson School of Medicine, and a Clinical Assistant Professor in the Department of Surgery at UCSF School of Medicine in California.

This program is produced in partnership with the American College of Chest Physicians and is sponsored by AstraZeneca.

Despite the typically poor prognosis of extensive-stage small cell lung cancer, recent advancements are reshaping clinical perspectives on treatment. New and emerging options show promise for prolonged survival and improved quality of life. Join Drs. Gerard Silvestri, Adam Fox, Mariam Alexander, and Anurag Singh as they discuss how the therapeutic landscape is evolving for these patients. Silvestri is a pulmonologist and the Hillenbrand Professor of Thoracic Oncology at the Medical University of South Carolina. Dr. Fox is a pulmonologist and Assistant Professor of Medicine at the Medical University of South Carolina. Dr. Alexander is a medical oncologist and Assistant Professor of Medicine at the Medical University of South Carolina. Dr. Singh is a Professor of Radiation Oncology and the Director of Radiation Research at the Roswell Park Cancer Center in New York.

This program is produced in partnership with the American College of Chest Physicians and is sponsored by AstraZeneca.