This DermSurgery Digest bonus content aptly named “At the Microscope” shares the latest research and techniques in dermatopathology. In this episode, we will review Atypical Fibroxanthoma and Pleomorphic Dermal Sarcoma. Contributors to this podcast include Naomi Lawrence, MD, Dermatologic Surgery Digital Content Editor; Ashley Elsensohn, MD, MPH, DermSurgery Digest at the Microscope co-host; Christine Ahn, MD; Jeff Gardner, MD; Marina K. Ibraheim, MD; and Michael P. Lee, MD.

Articles Reviewed: 

• Agaimy A. The many faces of Atypical fibroxanthoma. Semin Diagn Pathol. 2023 Jul;40(4):306-312. doi: 10.1053/j.semdp.2023.06.001. Epub 2023 Jun 23. PMID: 37438163. Link: https://pubmed.ncbi.nlm.nih.gov/37438163/
•  Ørholt M, Abebe K, Aaberg F, Rasmussen LE, Daugaard S, Loya AC, Herly M, Vester-Glowinski PV. Immunohistochemical Characteristics of Atypical Fibroxanthoma and Pleomorphic Dermal Sarcoma: A Systematic Review and Meta-Analysis. Am J Dermatopathol. 2022 Dec 1;44(12):913-920. doi: 10.1097/DAD.0000000000002305. PMID: 36395448. Link: https://pubmed.ncbi.nlm.nih.gov/36395448/
• van Midden D, Flucke UE, Amir AL, Bonenkamp JJ, Lubeek SFK, Blokx WAM. Atypical fibroxanthoma and pleomorphic dermal sarcoma: Is superficial infiltration in subcutaneous tissue acceptable in AFX? Ann Diagn Pathol. 2022 Jun;58:151915. doi: 10.1016/j.anndiagpath.2022.151915. Epub 2022 Feb 10. PMID: 35276548. Link: https://pubmed.ncbi.nlm.nih.gov/35276548/
• Anders IM, Schimmelpfennig C, Wiedemann K, Löffler D, Kämpf C, Blumert C, Reiche K, Kunz M, Anderegg U, Simon JC, Ziemer M. Atypical fibroxanthoma and pleomorphic dermal sarcoma - gene expression analysis compared with undifferentiated cutaneous squamous cell carcinoma. J Dtsch Dermatol Ges. 2023 May;21(5):482-491. doi: 10.1111/ddg.15006. Epub 2023 Apr 10. PMID: 37035902. Link: https://pubmed.ncbi.nlm.nih.gov/37035902/ 

Listeners are encouraged to submit questions for podcast hosts to answer in a later episode. To submit your questions, email [email protected].