This inaugural episode of a new DermSurgery Digest bonus content aptly named “At the Microscope” will share the latest research and techniques in dermatopathology as it is applicable to dermatologic surgery. In this episode, contributors will review recent literature around preferably expressed antigen in melanoma (PRAME) as a useful marker to support a suspected diagnosis of melanoma.

Contributors to this podcast include Naomi Lawrence, MD, Dermatologic Surgery Digital Content Editor; Ashley Elsensohn, MD, MPH, DermSurgery Digest at the Microscope co-host; Ami Greene, MD; Tara Jennings, MD; Yesul Kim, MD; and Catherine Motosko, MD.

Articles featured include:

1. Lezcano C, Jungbluth AA, Nehal KS, et al. PRAME expression in melanocytic tumors. Am J Surg Pathol. 2018;42:1456–1465.
2. Lezcano C, Jungbluth AA, Busam KJ. Comparison of immunohistochemistry for PRAME with cytogenetic test results in the evaluation of challenging melanocytic. Am J Surg Pathol. 2020;44:893–900.
3. de Wet J, Plessis PJD, Schneider JW. Staged Excision of Lentigo Maligna of the Head and Neck: Assessing Surgical Excision Margins With Melan A, SOX10, and PRAME Immunohistochemistry. Am J Dermatopathol. 2023 Feb 1;45(2):107-112. doi: 10.1097/DAD.0000000000002354.
4. Turner N, Ko CJ, McNiff JM, Galan A. Pitfalls of PRAME Immunohistochemistry in a Large Series of Melanocytic and Nonmelanocytic Lesions With Literature Review. Am J Dermatopathol. 2024 Jan 1;46(1):21-30. doi: 10.1097/DAD.0000000000002584.

Please submit questions to be answered in future episodes to [email protected].