This DermSurgery Digest bonus content, aptly named “At the Microscope,” shares the latest research and techniques in dermatopathology. In this episode, we will review tumor upstaging related to basal cell carcinoma, squamous cell carcinoma and melanoma. Contributors to this podcast include Naomi Lawrence, MD, Dermatologic Surgery Digital Content Editor; Ashley Elsensohn, MD, MPH, DermSurgery Digest at the Microscope co-host; Christine Ahn, MD; Jeff Gardner, MD; Marina K. Ibraheim, MD; and Michael P. Lee, MD.

 Articles featured in this episode include: 

• Pham D, Tabba D, Zhou C, Chow C, Elsensohn A. Histopathological discrepancy of biopsy specimens compared to subsequent Mohs surgery or wide local excision specimens. J Am Acad Dermatol. 2024 Sep;91(3):518-519. doi: 10.1016/j.jaad.2024.04.047. Epub 2024 Apr 27. PMID: 38685403. Link: https://pubmed.ncbi.nlm.nih.gov/38685403/
• Lim GF, Perez OA, Zitelli JA, Brodland DG. Correlation of basal cell carcinoma subtype with histologically confirmed subclinical extension during Mohs micrographic surgery: A prospective multicenter study. J Am Acad Dermatol. 2022 Jun;86(6):1309-1317. doi: 10.1016/j.jaad.2022.02.037. Epub 2022 Feb 26. PMID: 35231546. Link: https://pubmed.ncbi.nlm.nih.gov/35231546/
• Knackstedt TJ, Brennick JB, Perry AE, Li Z, Quatrano NA, Samie FH. Frequency of squamous cell carcinoma (SCC) invasion in transected SCC in situ referred for Mohs surgery: the Dartmouth-Hitchcock experience. Int J Dermatol. 2015 Jul;54(7):830-3. doi: 10.1111/ijd.12867. Epub 2015 Apr 27. PMID: 25920731. Link: https://pubmed.ncbi.nlm.nih.gov/25920731/
• Jackett LA, Gullifer JP, Scolyer RA. Evaluation of Multiple Tissue Levels Frequently Upstages Patients With Clinically Localized Thin Primary Cutaneous Melanoma. J Cutan Pathol. 2024 Oct 2. doi: 10.1111/cup.14726. Epub ahead of print. PMID: 39357975. Link: https://pubmed.ncbi.nlm.nih.gov/39357975/

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