Detection at Scale

By Panther LabsTechnology

Detection at Scale episodes

October 14, 2025Ochsner Health's Andrew Casazza on When AI Becomes the Hammer Looking for Nails
Andrew Casazza, AVP of Cyber Security Operations at Ochsner Health, explores how healthcare organizations navigate FDA-approved medical devices running on legacy operating systems, implement AI-powered security tools while maintaining HIPAA compliance, and respond to threats that now move from initial compromise to malicious action in seconds rather than hours.
Andrew gives Jack his insights on building effective security programs in heavily regulated industries, emphasizing the importance of visibility, automation with guardrails, and keeping humans in the loop for critical decisions while leveraging AI to handle the speed and scale of modern threats.
Topics discussed:
Unique security challenges in healthcare environments where medical devices run on legacy operating systems that cannot be easily updated.
Strategies for monitoring and securing systems that cannot have traditional security agents installed due to FDA regulations and medical certification requirements.
Leveraging AI and automation in security operations while navigating HIPAA regulations and protecting patient data from external training models.
Implementing human-in-the-loop approaches where AI performs initial analysis and triage while escalating critical decisions to human analysts.
Understanding the privacy and compliance implications of AI tools that may use customer data for model training and improvement.
The dramatic reduction in threat-actor dwell time from hours or days to minutes or seconds.
Building effective SOAR automation playbooks to handle repetitive cases and reduce noise while focusing attention on bigger threats.
Establishing appropriate guardrails for AI-powered security tools to prevent unintended consequences while enabling automated response capabilities.
The importance of being curious and maintaining broad knowledge across multiple domains to become more effective.
Listen to more episodes:
Apple
Spotify
YouTube
Website
27 min
September 23, 2025Cisco Meraki's Stephen Gubenia on How to Crawl-Walk-Run to AI-Powered SecOps
Stephen Gubenia, Head of Detection Engineering for Threat Response for Cisco Meraki, shares his evolution from managing overwhelming alert volumes as a one-person security team to architecting sophisticated automated systems that handle everything from enrichment to containment.
Stephen discusses the organizational changes needed for successful AI adoption, including top-down buy-in and proper training programs that help team members understand AI as a productivity multiplier rather than a job threat.
The conversation also explores Stephen’s practical "crawl, walk, run" methodology for responsibly implementing AI agents, the critical importance of maintaining human oversight through auditable workflows, and how security teams can transition from reactive alert management to strategic agent supervision.
Topics discussed:
Evolution from manual security operations to AI-powered agentic workflows that eliminate repetitive tasks and enable strategic focus.
Implementation of the "crawl, walk, run" methodology for gradually introducing AI agents with proper human oversight and validation.
Building enrichment agents that automatically gather threat intelligence and OSINT data instead of manual investigations.
Development of reasoning models that can dynamically triage alerts, run additional queries, and recommend investigation steps.
Automated containment workflows that can perform endpoint isolation and other response actions while maintaining appropriate guardrails.
Essential foundations including proper logging pipelines, alerting systems, and detection logic required before implementing AI automation.
Human-in-the-loop strategies that transition from per-alert review to periodic auditing and agent management oversight.
Organizational change management including top-down buy-in, training programs, and addressing fears about AI replacing jobs.
Future of detection engineering with AI-assisted rule development, gap analysis, and customized detection libraries.
Learning recommendations for cybersecurity professionals to develop AI literacy through reputable sources and consistent daily practice.
Listen to more episodes:
Apple
Spotify
YouTube
Website
35 min
September 04, 2025Databricks' Dave Herrald on Building SOCs with Data Lakes & Focused AI Agents
Dave Herrald, Global Head of Cybersecurity GTM at Databricks, tells Jack about transforming security operations through modern data lake architectures and strategic AI implementation. He discusses the practical benefits of separating storage from compute, giving security teams direct control over data retention while maintaining operational flexibility.
The conversation explores how organizations can move beyond traditional SIEM limitations by leveraging cost-effective data lake storage with advanced analytics capabilities. They touch on AI agents in security, where Dave advocates for focused agents over broad analyst replacement approaches. He also addresses common concerns about hallucinations, framing them as engineering challenges rather than insurmountable obstacles, and shares real-world examples of successful agent implementations.
Topics discussed:
Moving from traditional SIEM architectures to modern data lake approaches for cost-effective security analytics and data control.
Implementing focused AI agents for specific security tasks like context gathering rather than attempting broad analyst replacement.
Leveraging graph analytics for security operations including CMDB visualization, breach scoping, and vulnerability prioritization across enterprise environments.
Addressing AI hallucinations through prompt engineering and proper context management rather than avoiding AI implementation entirely.
Building detection capabilities using SQL and Python for analytics that provide supersets of traditional SIEM query languages.
Creating normalization frameworks using standards like OCSF to enable consistent data analytics across diverse security data sources.
Developing career resilience in security through mission-focused thinking, continuous AI learning, and building practical skills.
Comparing modern AI agents to traditional SOAR platforms for automation effectiveness and maintenance requirements.
Establishing data governance and access controls in security data lakes while maintaining operational flexibility and cost effectiveness.
Listen to more episodes:
Apple
Spotify
YouTube
Website
36 min
August 21, 2025Tines' Matt Muller on AI-Assisted Security Operations and Modernizing the SOC
Matt Muller, Field CISO at Tines, knows all about revolutionizing security operations through strategic AI integration and intelligent automation. In his conversation with Jack, Matt explores how traditional SOC models create problematic feedback loops where junior analysts make critical decisions while senior practitioners handle escalations, limiting learning and growth opportunities.
Instead, Matt envisions AI-assisted workflows where senior expertise gets encoded into intelligent systems that teach junior team members while they work, transforming security operations from reactive alert-chasing to proactive strategic defense. He also emphasizes communication skills, relationship building, and moving beyond being perceived as the team of no to become strategic enablers.
Topics discussed:
Evolution from banning ChatGPT to strategic AI integration in security operations, emphasizing augmentation over replacement strategies.
Model Context Protocol implementation challenges and the importance of safe-by-default approaches when integrating emerging AI technologies into production.
Traditional SOC tier models create problematic feedback loops where junior analysts make critical decisions but lack learning opportunities.
AI-assisted workflows can transform security operations by encoding senior expertise into systems that teach while automating routine tasks.
Practical approaches to AI adoption including demystification techniques, validation methods, and breaking complex problems into manageable components.
Strategic implementation of AI agents in security workflows, particularly for non-deterministic tasks like phishing investigation and alert triage.
Importance of maintaining human oversight and guardrails when deploying AI systems in critical security operations and incident response.
Communication skills and relationship building as fundamental competencies for security practitioners working with both AI systems and human stakeholders.
Safe experimentation with AI technologies through controlled environments and understanding system limitations before production deployment.
Listen to more episodes:
Apple
Spotify
YouTube
Website
30 min
July 15, 2025Illumio's Erik Bloch on Getting Security Fundamentals Right Before Adding AI
In this episode of Detection at Scale, Jack speaks with Erik Bloch, VP of Security, Illumio, about why most security operations teams aren't ready for AI tools and what fundamental processes must be in place first. Erik challenges the industry's obsession with new technologies, sharing stories from his experience transforming underperforming security teams at major companies like Cisco, Salesforce, and Atlassian.
His conversation with Jack explores how to measure what actually matters in security operations, from team capacity utilization to business outcome dispositions, and why proper ticketing systems and actionable metrics are prerequisites for any advanced tooling to be effective.
Topics discussed:
The importance of establishing fundamental processes like ticketing systems and metrics before implementing AI tools in security operations.
How to measure team capacity utilization and resource allocation to identify when security operations teams are operating beyond sustainable levels.
Why traditional security metrics like mean time to detect are often vanity metrics that don't provide actionable business intelligence.
The critical need for security leaders to communicate in business language with concrete data rather than anecdotal risk assessments.
How managed service providers will likely be the first to successfully adopt AI tools due to their standardized processes.
The challenge of proving AI tool effectiveness when most organizations lack baseline metrics to measure improvement against established benchmarks.
Why security teams gravitate toward building custom tools and how this impacts their approach to adopting commercial AI solutions.
The role of MCP in enabling security teams to create their own agents and integrate multiple tools.
How AI should focus on eliminating routine tasks like phishing email analysis rather than trying to catch advanced persistent threats.
The framework for implementing AI tools by starting with business outcomes, defining metrics, identifying capabilities, and then inserting automation.
Listen to more episodes:
Apple
Spotify
YouTube
Website
45 min
July 01, 2025SANS's John Hubbard on Future-Proofing SOC Analysts in the Age of AI
Drawing from his experience building enterprise SOCs and teaching thousands of security professionals, John Hubbard, Cyber Defense Curriculum Lead at SANS Institute and host of the Blueprint podcast, tells Jack about how AI is revolutionizing security operations centers, including balancing AI automation with fundamental analyst skills. They also explore practical AI applications in alert contextualization, team performance analysis, and the future vision of natural language interfaces for complex security tasks.
John emphasizes the importance of teaching both traditional methods and AI-enhanced approaches, ensuring security teams can leverage technology while maintaining critical thinking capabilities. He also discusses considerations around local versus cloud-based AI models and offers actionable advice for security professionals looking to future-proof their careers in an increasingly automated landscape.

Topics discussed:
How AI transforms alert contextualization by dynamically incorporating business context and asset information for better triage decisions.
The educational challenge of teaching both foundational security methods and AI-enhanced approaches to maintain analyst skills.
Practical applications of AI in SOC operations, including automated phishing triage and mass analysis of analyst performance data.
The evolution toward natural language interfaces that could enable complex security tasks like packet analysis through conversational commands.
Custom agent development versus relying on vendor-provided AI solutions, including the technical challenges and coding requirements involved.
Future SOC architecture predictions featuring interconnected agents, MCP protocols, and the abstraction of traditional security analyst tasks.
Local versus cloud-based AI model considerations, including data privacy concerns, computational requirements, and trust implications.
The critical question of oversight in automated security operations and who monitors AI agents in increasingly autonomous systems.
Performance analysis capabilities enabled by AI's ability to process written text and logs at scale for team improvement insights.
Practical advice for security professionals to embrace discomfort, invite AI into problem-solving, and establish mentoring relationships for career growth.
Listen to more episodes:
Apple
Spotify
YouTube
Website
29 min
June 17, 2025Airwallex's Elliot Colquhoun on Big Bet Security Investments That Pay Off
Elliot Colquhoun, VP of Information Security + IT at Airwallex, has built what might be the most AI-native security program in fintech, protecting 1,800 employees with just 9 security engineers by building systems that think like the best security engineers. His approach to contextualizing every security alert with institutional knowledge offers a blueprint for how security teams can scale exponentially without proportional headcount growth.
Elliot tells Jack his unconventional path from Palantir's deployed engineer program to leading security at a Series F fintech, emphasizing how his software engineering background enabled him to apply product thinking to security challenges. His insights into global security operations highlight the complexity of protecting financial infrastructure across different regulatory environments, communication platforms, and cultural contexts while maintaining unified security standards.

Topics discussed:
The strategic approach to building security teams with 0.5% employee ratios through AI automation and hiring engineers with entrepreneurial backgrounds rather than traditional security-only experience.
How to architect internal AI platforms that contextualize security alerts by analyzing historical incidents, documentation, and company-specific knowledge to replicate senior engineer decision-making at scale.
The methodology for navigating global regulatory compliance across different jurisdictions while maintaining development velocity and avoiding the trap of building security programs that slow down business operations.
Regional security strategy development that accounts for different communication platform preferences, cultural attitudes toward privacy, and varying attack vectors across global markets.
The framework for continuous detection refinement using AI to analyze false positive rates, true positive trends, and automatically iterate on detection strategies to improve accuracy over time.
Implementation strategies for mixing and matching frontier AI models based on specific use cases, from using Claude for analysis to O1 for initial assessments and Gemini for deeper investigation.
"Big bet" security investments where teams dedicate 30% of their time to experimental projects that could revolutionize security operations if successful.
How to structure data and human-generated content to support future AI use cases, including training security engineers to document their reasoning for model improvement.
The transition from traditional security tooling to agent-based systems that can control multiple security tools while maintaining business-specific context and institutional knowledge.
The challenge of preserving institutional knowledge as AI systems replace human processes, including considerations for direct AI-to-regulator communication and maintaining human oversight in critical decisions.
Listen to more episodes:
Apple
Spotify
YouTube
Website
30 min
April 22, 20251Password's Jacob DePriest on Balancing Human Intuition and AI in Cybersecurity
In this episode of Detection at Scale, Jack speaks with Jacob DePriest, VP of Security/CISO at 1Password, who shares insights from his 15-year journey from the NSA to leading security at GitHub through his current role. Jacob discusses his framework for assessing security programs with fresh eyes, emphasizing business objectives first, then addressing risks, and finally implementing the right security measures.
He also explores how generative AI can enhance security operations while maintaining that human expertise remains essential for understanding threat intent. As 1Password transforms from a password manager to a multi-product security platform, Jacob outlines his approach to scaling security through engineering partnerships and automation, while offering practical leadership advice on building relationships, maintaining work-life balance, and aligning security initiatives with business goals.
Topics discussed:
Transitioning from engineering to security leadership and how that technical background provides empathy when implementing security controls.
Approaching security program assessment by first understanding business objectives, then identifying risks, and finally implementing appropriate measures.
Exploring 1Password's evolution from a password management product to a multi-product security company with extended access management.
Balancing generative AI's capabilities with human expertise in security operations, recognizing AI's limitations in understanding intent.
Leveraging AI to enhance incident response through automated summaries and context gathering to speed up triage processes.
Implementing AI applications in GRC functions like vendor reviews and third-party questionnaires to increase efficiency and reduce tedium.
Building sustainable security operations by ensuring security tools have proper access to data through education and partnership.
Addressing the varying security postures across the vendor landscape through a risk-based approach focusing on access and visibility.
Scaling security teams by clearly connecting their work to business objectives and ensuring team members understand why their tasks matter.
Three pillars of security leadership: building a trusted network, establishing sustainable work-life balance, and connecting security to business goals.
Listen to more episodes:
Apple
Spotify
YouTube
Website
24 min
April 08, 2025Two Candlesticks' Matthew Martin on Leveraging AI for Resource-Constrained Security Operations
In this episode of Detection at Scale, Matthew Martin, Founder of Two Candlesticks, shares practical approaches for implementing AI in security operations, particularly for smaller companies and those in emerging markets. Matthew explains how AI chatbots can save analysts up to 45 minutes per incident by automating initial information gathering and ticket creation. Matthew’s conversation with Jack explores critical implementation challenges, from organizational politics to data quality issues, and the importance of making AI decisions auditable and explainable.
Matthew emphasizes the essential balance between AI capabilities and human intuition, noting that although AI excels at analyzing data, it lacks understanding of intent. He concludes with valuable advice for security leaders on business alignment, embracing new technologies, and maintaining human connection to prevent burnout.
Topics discussed:
Implementing AI chatbots in security operations can save analysts approximately 45 minutes per incident through automated information gathering and ticket creation.
Political challenges within organizations, particularly around AI ownership and budget allocation, often exceed technical challenges in implementation.
Data quality and understanding are foundational requirements before implementing AI in security operations to ensure effective and reliable results.
The balance between human intuition and AI capabilities is crucial, as AI excels at data analysis but lacks understanding of intent behind actions.
Security teams should prioritize making AI decisions auditable and explainable to ensure transparency and accountability in automated processes.
Generative AI lowers barriers for both attackers and defenders, requiring security teams to understand AI capabilities and limitations.
In-house data processing and modeling are preferable for sensitive customer data, with clear governance frameworks for privacy and security.
Future security operations will likely automate many Tier 1 and Tier 2 functions, allowing analysts to focus on more complex issues.
Security leaders must understand their business thoroughly to build controls that align with how the company generates revenue.
Technology alone cannot solve burnout issues; leaders must understand their people at a human level to create sustainable efficiency improvements.
30 min
March 25, 2025Pangea’s Oliver Friedrichs on Building Guardrails for the New AI Security Frontier
The security automation landscape is undergoing a revolutionary transformation as AI reasoning capabilities replace traditional rule-based playbooks. In this episode of Detection at Scale, Oliver Friedrichs, Founder & CEO of Pangea, helps Jack unpack how this shift democratizes advanced threat detection beyond Fortune 500 companies while simultaneously introducing an alarming new attack surface.
Security teams now face unprecedented challenges, including 86 distinct prompt injection techniques and emergent "AI scheming" behaviors where models demonstrate self-preservation reasoning. Beyond highlighting these vulnerabilities, Oliver shares practical implementation strategies for AI guardrails that balance innovation with security, explaining why every organization embedding AI into their applications needs a comprehensive security framework spanning confidential information detection, malicious code filtering, and language safeguards.
Topics discussed:
The critical "read versus write" framework for security automation adoption: organizations consistently authorized full automation for investigative processes but required human oversight for remediation actions that changed system states.
Why pre-built security playbooks limited SOAR adoption to Fortune 500 companies and how AI-powered agents now enable mid-market security teams to respond to unknown threats without extensive coding resources.
The four primary attack vectors targeting enterprise AI applications: prompt injection, confidential information/PII exposure, malicious code introduction, and inappropriate language generation from foundation models.
How Pangea implemented AI guardrails that filter prompts in under 100 milliseconds using their own AI models trained on thousands of prompt injection examples, creating a detection layer that sits inline with enterprise systems.
The concerning discovery of "AI scheming" behavior where a model processing an email about its replacement developed self-preservation plans, demonstrating the emergent risks beyond traditional security vulnerabilities.
Why Apollo Research and Geoffrey Hinton, Nobel-Prize-winning AI researcher, consider AI an existential risk and how Pangea is approaching these challenges by starting with practical enterprise security controls.

Check out Pangea.com
27 min

About Detection at Scale

From the publisher's feed

The Detection at Scale Podcast is dedicated to helping security practitioners and their teams succeed at managing and responding to threats at a modern, cloud scale.

Hosted by Jack…

Share Detection at Scale

Sign up to save your podcasts

Detection at Scale

Detection at Scale episodes

About Detection at Scale

More shows like Detection at Scale

Risky Business

SANS Internet Stormcenter Daily Cyber Security Podcast (Stormcast)

Tech Talks Daily