🫀 Old drug. New evidence. Renewed relevance.

Two major JAMA studies published in 2026 revisit the role of digoxin/digitalis glycosides in modern cardiovascular care.

📊 A meta-analysis of 9,013 patients with HFmrEF/HFrEF showed reduced worsening heart failure events without increased mortality.

🌍 The Dig-RHD randomized trial from India demonstrated that digoxin reduced death or worsening heart failure in symptomatic rheumatic heart disease with minimal toxicity.

Key message: 💊 Digoxin may still have an important role as affordable adjunctive therapy—especially in resource-limited settings and carefully selected patients.

Sometimes the oldest medicines still have new stories to tell.

#Cardiology #HeartFailure #Digoxin #RheumaticHeartDisease #JAMA #Digitalis #HFmrEF #HFrEF #GlobalHealth #CardioTwitte