Discover CircRes

This month on Episode 58 of Discover CircRes, host Cynthia St. Hilaire highlights three original research articles featured in the March 1 and March 15th issues of Circulation Research. This Episode also includes a discussion with Drs Frank Faraci, Tami Martino, and Martin Young about their contributions to the Compendium on Circadian Mechanisms in Cardiovascular and Cerebrovascular Disease.

Article highlights:

Yan, et al. GCN2 in Ponatinib-Induced Cardiotoxicity

Wang, et al. Activating v-ATPase Ameliorates Cardiac Cardiomyopathy

This month on Episode 57 of Discover CircRes, host Cynthia St. Hilaire highlights three original research articles featured in the February 2nd and February 19th issues of Circulation Research. This Episode also includes a discussion with Dr Kathryn Howe and Dr Sneha Raju from University of Toronto, about their manuscript titled Directional Endothelial Communication by Polarized Extracellular Vesicle Release.

Article highlights:

Ren, et al. ZBTB20 Regulates Cardiac Contractility

Faleeva, et al. Sox9 Regulates Vascular Extracellular Matrix Aging

Bai, et al. PKA Is Critical for Cardiac Growth

Wang, et al. Indole-3-Propionic Acid Protects Against HFpEF

This month on Episode 56 of Discover CircRes, host Cynthia St. Hilaire highlights three original research articles featured in the January 5th and January 19th issues of Circulation Research. This Episode also includes a discussion with Dr Julie Freed and Gopika Senthilkumar from the Medical College of Wisconsin about their study, Necessary Role of Ceramides in the Human Microvascular Endothelium During Health and Disease.

Article highlights:

He, et al. T Cell LGMN Deficiency Prevents Hypertension

Salyer, et al. TnI-Y26 Phosphorylation Improves Relaxation

Jacob, et al. MFN2 in Megakaryocyte and Platelet Function

This month on Episode 55 of Discover CircRes, host Cynthia St. Hilaireaire highlights two original research articles featured in the December 8th issue of Circulation Research. This Episode also includes a discussion with Dr José Luis de la Pompa and Dr Luis Luna-Zurita from the National Center for Cardiovascular Research in Spain about their study, Cooperative Response to Endocardial NOTCH Reveals Interaction With Hippo Pathway.

Article highlights:

Shi, et al. Nat10 Mediated ac4C in Cardiac Remodeling

Knight, et al. CDK4 Oxidation Attenuates Cell Proliferation

This month on Episode 54 of Discover CircRes, host Cynthia St. Hilaire highlights three original research articles featured in the October 27th and November 10th issues of Circulation Research. This Episode also includes a discussion with Dr Sophie Susen and Dr Caterina Casari about their study, Shear Forces Induced Platelet Clearance Is a New Mechanism of Thrombocytopenia, published in the October 27th issue.

Article highlights:

Pass, et al. Single Nuclei Transcriptome of PAD Muscle

Liu, et al. Myocardial Recovery in DCM: CDCP1 and Fibrosis

Grego-Bessa, et al. Neuregulin-1 Regulates Chamber Morphogenesis

Agrawal, et al. A New Model of PH due to HFpEF

This month on Episode 53 of Discover CircRes, host Cynthia St. Hilaire highlights three original research articles featured in the September 29th and October 13th issues of Circulation Research. This Episode also includes a discussion with Dr Margaret Schwarz and Dr Dushani Ranasinghe about their study, Altered Smooth Muscle Cell Histone Acetylome by the SPHK2/S1P Axis Promotes Pulmonary Hypertension, published in the September 29 issue.

Article highlights:

Serio, et al. p300/CBP-Upregulated Glycolysis and Cardiac Aging

Sharifi, et al. ADAMTS-7 and TIMP-1 in Atherosclerosis

Zhang, et al. TMEM215 Represses Endothelial Apoptosis

Perike, et al. PPP1R12C Promotes Atrial Hypocontractility in AF

This month on Episode 52 of Discover CircRes, host Cynthia St. Hilaire highlights three original research articles featured in the September 1 and September 15th issues of Circulation Research. This Episode also includes a discussion with Dr Manuel Mayr about the study, Proteomic Atlas of Atherosclerosis, the Contribution of Proteoglycans to Sex Differences, Plaque Phenotypes and Outcomes, published in the September 15 issue.

Article highlights:

Sun, et al. CCND2 modRNA Remuscularization Hearts with AMI

Ho, et al. Lymphatic Genes Prevent Cardiac Valve Disease

Shanks, et al. Cardiac Vagal Activity Increases During Exercise

This month on Episode 51 of Discover CircRes, host Cynthia St. Hilaire highlights four original research articles featured in the August 4th and August 18th issues of Circulation Research. This Episode also includes a discussion with Dr Eric Small and Dr Xiaoyi Liu from the University of Rochester Medical Center about their article p53 Regulates the Extent of Fibroblast Proliferation and Fibrosis in Left Ventricular Pressure Overload, published in the July 21st issue of the journal.

Article highlights:

Régnier, et al. CTLA-4 Pathway Is Pivotal in Giant Cell Arteritis

Zarkada, et al. Chylomicrons Regulate Lacteal Permeability

Schuermans, et al. Age at Menopause, Telomere Length, and CAD

Bayer, et al. T-cell MyD88 Regulates Fibrosis in Heart Failure

This month on Episode 50 of Discover CircRes, host Cynthia St. Hilaire highlights four original research articles featured in the June 23, July 7, and July 21 issues of Circulation Research. This Episode also includes a discussion with BCVS Outstanding Early Career Investigator Award Qiongxin Wang from University of Washington St. Louis, Haobo Li from Massachusetts General Hospital, and Asma Boukhalfa from Tufts Medical Center.

Article highlights:

Tong, et al. The Role of DRP1 in Mitophagy

Abe, et al. ERK5-NRF2 Axis and Senescence-Associated Stemness

Dai, et al. Therapeutic Targeting of Endocytosis Defects in DCM

Weng, et al. PDCD5 Suppresses Cardiac Fibrosis

This month on Episode 49 of Discover CircRes, host Cynthia St. Hilaire highlights two original research articles featured in the May 26th issue and provides an overview of the June 9th Compendium on Early Cardiovascular Disease of Circulation Research. This Episode also includes a discussion with Dr Tejasvi Dudiki and Dr Tatiana Byzova about their study, Mechanism of Tumor Platelet Communications in Cancer.

Article highlights:

Nichtová, et al. Mitochondria-SR Tethering and Cardiac Remodeling

Ferrucci, et al. Muscle Transcriptomic and Proteomic in PAD

Compendium on Early Cardiovascular Disease.