Discover CircRes

This month on Episode 68 of Discover CircRes, host Cindy St. Hilaire highlights four articles featured in the January 3rd and January 17th issues of Circulation Research. This Episode also includes a discussion with Drs Gianluigi Condorelli and Marinos Kallikourdis about their study Autoimmune-like Mechanism in Heart Failure Enables Preventative Vaccine Therapy.

Article highlights:

Yoshida, et al. FAP Vaccine Improves Cardiac Fibrosis

Johansen, et al. TCF21 and Cardiac Fibrosis

Pabon, et al. Endothelial METAP1 in Preeclampsia

Mutchler, et al. ET-3/ETBR, Immune Cells, and Kidney Lymphatics

This month on Episode 67 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the December 6th issues of Circulation Research. This Episode also includes a discussion with Drs Jesse Rowley and Shancy Jacob about their study, Mitofusin-2 Regulates Platelet Mitochondria and Function.

Article highlights:

Bardhan, et al. Sex Specific Roles of Microbiota in Hypertension

Ma, et al. Kindlin-2 LLPS Controls Vascular Stability

Wang, et al. CAR-Ms Alleviate Myocardial I/R Injury

This month on Episode 66 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the October 25th and November 8th issues of Circulation Research. This Episode also includes a discussion with Dr Jil Tardiff and Dr Melissa Lynn about their study, Arg92Leu-cTnT Alters the cTnC-cTnI Interface Disrupting PKA-Mediated Relaxation.

Article highlights:

Lou, et al. Visualizing irAEs in Atherosclerosis

Yoshii, et al. Defective Mitophagy Response in HFpEF Heart

Zeller, et al. Shear Stress Dissociates C-Reactive Protein

Chen, et al. EPHB4-RASA1 Regulation of Lymphatic Valvulogenesis

This month on Episode 65 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the September 27th and October 11th issues of Circulation Research. This Episode also includes a discussion with Dr Ken Walsh and Dr Ariel Polizio about their study, Experimental TET2 Clonal Hematopoiesis Predisposes to Renal Hypertension Through an Inflammasome-Mediated Mechanism.

Article highlights:

Ju, et al. NAE1 Crotonylation Regulates Cardiac Hypertrophy

Pirri, et al. EPAS1 Atheroprotection via Fatty Acid Metabolism

Saleem, et al. Myeloid CD11c+ Cells and JAK2/STAT3/SMAD3 in SSBP

Pietsch, et al. Chronic Activation of Tubulin Tyrosination

This month on Episode 63 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the August 2nd and August 16th issues of Circulation Research. This Episode also includes a discussion with Drs Chen Gao and Yibin Wang about their study, Glucagon Receptor Antagonist for Heart Failure with Preserved Ejection Fraction

Article highlights:

Douvdevany, et al. Imaging the Turnover of the Sarcomere

Quelquejay, et al. Wnk1 Deletion in Smooth Muscle Cells Induces Aortitis

Paulke, et al. The Role of Dysferlin in Cardiac Hypertrophy

Morais, et al. Predictors of Outcome in SPAN

This month on Episode 62 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the July 5th and July 19th issues of Circulation Research. This Episode also includes a discussion with the four finalists for the Basic Cardiovascular Sciences Outstanding Early Career Investigator Award.

Article highlights:

Mallaredy, et al. Extracellular Vesicle Reduction Prevents Heart Failure

Mori, et al. CD163 Macrophages and EndMT in Plaque Progression

Wang, et al. Rbx2 Regulates Mitophagy

Nakayama, et al. ARRDC4 Limits Cardiac Reserve in Diabetes

This month on Episode 61 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the June 7th and June 21st issues of Circulation Research. This Episode also includes a discussion with Dr Chris O'Callaghan and Jiahao Jiang from the University of Oxford about their study, A Novel Macrophage Subpopulation Conveys Increased Genetic Risk of Coronary Artery Disease.

Article highlights:

Compendium on Interface Between Cardioimmunology, Myocardial Health, and Disease

Zafeiropoulo, et al. Splenic Ultrasound Improves Pulmonary Hypertension

Roman, et al. MICU3 Enhances Mitochondrial Ca2+ Uptake

This month on Episode 60 of Discover CircRes, host Cindy St. Hilaire highlights original research articles featured in the May 10 and May 24th issues of Circulation Research. This Episode also includes a discussion with Dr Sophie Astrof and Dr AnnJosette Ramirez from Rutgers University about their study, Buffering Mechanism in Aortic Arch Artery Formation and Congenital Heart Disease.

Article highlights:

Tamiato, et al. Pericyte RGS5 in Cardiac Aging

Zifkos, et al. PTP1B and Venous Thromboinflammation

Ma, et al. NR4A3 in Vascular Calcification

Sultan, et al. VEGF-B Induced Coronary Endothelial Cell Lineage

This month on Episode 59 of Discover CircRes, host Cindy St. Hilaire highlights original research articles featured in the April 12 and April 26th issues of Circulation Research. This Episode also includes a discussion with Dr Craig Morrell and Chen Li from University of Rochester about their study, Thrombocytopenia Independently Leads to Changes in Monocyte Immune Function.

Article highlights:

Arkelius, et al. LOX-1 and MMP-9 Inhibition Improves Stroke Outcomes

Cruz, et al. C122Y Disrupts Kir2.1-PIP2 Interaction in ATS1

Blaustein, et al. Environmental Impacts on Cardiovascular Health and Biology: An Overview