Discover CircRes

This month on Episode 66 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the October 25th and November 8th issues of Circulation Research. This Episode also includes a discussion with Dr Jil Tardiff and Dr Melissa Lynn about their study, Arg92Leu-cTnT Alters the cTnC-cTnI Interface Disrupting PKA-Mediated Relaxation.

Article highlights:

Lou, et al. Visualizing irAEs in Atherosclerosis

Yoshii, et al. Defective Mitophagy Response in HFpEF Heart

Zeller, et al. Shear Stress Dissociates C-Reactive Protein

Chen, et al. EPHB4-RASA1 Regulation of Lymphatic Valvulogenesis

This month on Episode 65 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the September 27th and October 11th issues of Circulation Research. This Episode also includes a discussion with Dr Ken Walsh and Dr Ariel Polizio about their study, Experimental TET2 Clonal Hematopoiesis Predisposes to Renal Hypertension Through an Inflammasome-Mediated Mechanism.

Article highlights:

Ju, et al. NAE1 Crotonylation Regulates Cardiac Hypertrophy

Pirri, et al. EPAS1 Atheroprotection via Fatty Acid Metabolism

Saleem, et al. Myeloid CD11c+ Cells and JAK2/STAT3/SMAD3 in SSBP

Pietsch, et al. Chronic Activation of Tubulin Tyrosination

This month on Episode 64 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the August 30th and September 13th issues of Circulation Research. This Episode also includes a discussion with Drs Stephanie Chung, Ahmed Gharib, and Khalid Abd-Elmoniem from NIDDK about their study, Endothelial Dysfunction in Youth-Onset Diabetes Type 2, A Clinical Translational Study.

Article highlights:

Zhao, et al. AMPK Phosphorylation of β-Arrestin-1 Blocking β-AR

Bashore, et al. Monocytes Profiling and Cardiovascular Disease

Chu, et al. Oxysterol-GPR183 Axis and Endothelial Senescence

Sigle, et al. Targeting Secreted Cyclophilin A in Failing Hearts

This month on Episode 63 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the August 2nd and August 16th issues of Circulation Research. This Episode also includes a discussion with Drs Chen Gao and Yibin Wang about their study, Glucagon Receptor Antagonist for Heart Failure with Preserved Ejection Fraction

Article highlights:

Douvdevany, et al. Imaging the Turnover of the Sarcomere

Quelquejay, et al. Wnk1 Deletion in Smooth Muscle Cells Induces Aortitis

Paulke, et al. The Role of Dysferlin in Cardiac Hypertrophy

Morais, et al. Predictors of Outcome in SPAN

This month on Episode 62 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the July 5th and July 19th issues of Circulation Research. This Episode also includes a discussion with the four finalists for the Basic Cardiovascular Sciences Outstanding Early Career Investigator Award.

Article highlights:

Mallaredy, et al. Extracellular Vesicle Reduction Prevents Heart Failure

Mori, et al. CD163 Macrophages and EndMT in Plaque Progression

Wang, et al. Rbx2 Regulates Mitophagy

Nakayama, et al. ARRDC4 Limits Cardiac Reserve in Diabetes

This month on Episode 61 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the June 7th and June 21st issues of Circulation Research. This Episode also includes a discussion with Dr Chris O'Callaghan and Jiahao Jiang from the University of Oxford about their study, A Novel Macrophage Subpopulation Conveys Increased Genetic Risk of Coronary Artery Disease.

Article highlights:

Compendium on Interface Between Cardioimmunology, Myocardial Health, and Disease

Zafeiropoulo, et al. Splenic Ultrasound Improves Pulmonary Hypertension

Roman, et al. MICU3 Enhances Mitochondrial Ca2+ Uptake

This month on Episode 60 of Discover CircRes, host Cindy St. Hilaire highlights original research articles featured in the May 10 and May 24th issues of Circulation Research. This Episode also includes a discussion with Dr Sophie Astrof and Dr AnnJosette Ramirez from Rutgers University about their study, Buffering Mechanism in Aortic Arch Artery Formation and Congenital Heart Disease.

Article highlights:

Tamiato, et al. Pericyte RGS5 in Cardiac Aging

Zifkos, et al. PTP1B and Venous Thromboinflammation

Ma, et al. NR4A3 in Vascular Calcification

Sultan, et al. VEGF-B Induced Coronary Endothelial Cell Lineage

This month on Episode 59 of Discover CircRes, host Cindy St. Hilaire highlights original research articles featured in the April 12 and April 26th issues of Circulation Research. This Episode also includes a discussion with Dr Craig Morrell and Chen Li from University of Rochester about their study, Thrombocytopenia Independently Leads to Changes in Monocyte Immune Function.

Article highlights:

Arkelius, et al. LOX-1 and MMP-9 Inhibition Improves Stroke Outcomes

Cruz, et al. C122Y Disrupts Kir2.1-PIP2 Interaction in ATS1

Blaustein, et al. Environmental Impacts on Cardiovascular Health and Biology: An Overview

This month on Episode 58 of Discover CircRes, host Cynthia St. Hilaire highlights three original research articles featured in the March 1 and March 15th issues of Circulation Research. This Episode also includes a discussion with Drs Frank Faraci, Tami Martino, and Martin Young about their contributions to the Compendium on Circadian Mechanisms in Cardiovascular and Cerebrovascular Disease.

Article highlights:

Yan, et al. GCN2 in Ponatinib-Induced Cardiotoxicity

Wang, et al. Activating v-ATPase Ameliorates Cardiac Cardiomyopathy

This month on Episode 57 of Discover CircRes, host Cynthia St. Hilaire highlights three original research articles featured in the February 2nd and February 19th issues of Circulation Research. This Episode also includes a discussion with Dr Kathryn Howe and Dr Sneha Raju from University of Toronto, about their manuscript titled Directional Endothelial Communication by Polarized Extracellular Vesicle Release.

Article highlights:

Ren, et al. ZBTB20 Regulates Cardiac Contractility

Faleeva, et al. Sox9 Regulates Vascular Extracellular Matrix Aging

Bai, et al. PKA Is Critical for Cardiac Growth

Wang, et al. Indole-3-Propionic Acid Protects Against HFpEF