Discover CircRes

This month on Episode 88 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the August 28th and September 11th issues of Circulation Research. This Episode also features a discussion with Dr Klaus Ley about his study, "Increased Autoreactive CD8+ T Cells to Apolipoprotein B Epitopes in Patients with Severe Coronary Artery Disease."

Article highlights:

Wang, et al. Methylmalonate Drives Diabetic Heart Damage

Zheng, et al. TLS and CXCL13 Axis in Intracranial Aneurysms

Zhou, et al. A Glyco-Epigenetic Driver of Heart Failure

Wang, et al Formononetin as an ERRα Agonist Alleviates AIC

This month on Episode 87 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the July 31st and August 14th issues of Circulation Research. This Episode also features a discussion with Drs Jonathan Kirk, Laura Sherer, and Abigail Nagle about their study, "Contractility Drives Cardiomyocyte Maturation and the Response to Nanopatterns."

Article highlights:

Zhang, et al. Mitochondrial STING Reprograms Glycolysis

Daou, et al. TFEB Antagonizes Pathological Cardiac Hypertrophy

Crepin, et al. Macrophage Subsets Contribute to Atrial Remodeling

Okamura, et al. Stochastic Resonance Prevents Sinus Arrest

This month on Episode 86 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the July 6 and July 17th issues of Circulation Research. This Episode also features a discussion with BCVS Outstanding Early Career Investigator Award Finalists, Drs Noor Momin, Shibali Das, and Ivan Menendez-Montes.

Article highlights:

Kotla, et al. LATS1/2-CD38-SUOX Axis Drives Intraplaque Thrombosis

Lin, et al. ATAD3A Gates Mito-Lysosome Contacts in AAD

Wang, et al. Monocyte Dll4 Induces Systemic Inflammation

Chattopadhyay, et al. S100A8/A9 Aggravate Atherosclerosis

This month on Episode 85 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the May 22nd, June 5th and June 19th issues of Circulation Research. This Episode also features a discussion with Professor Katrin Schäfer, Dr Rajinikanth Gogiraju, and Dr Beichen Sun, about their study, Chronic Erythrocyte NO Production Accelerates Atherosclerosis by Increasing SMC De Novo Lipogenesis.

Article highlights:

Larcher, et al. Cardiac Fibroblast Heterogeneity and Disease

Huang, et al. Vascular Endothelial NOX1 Drives Obesity

Atici, et al. Role of Sirtuin-1 in Murine Vasculitis

Compendium on Lipoproteins and Cardiovascular Disease

This month on Episode 84 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the April 24th and May 8th issue of Circulation Research. This Episode also features a discussion with Dr Mete Civelek and Dr Noah Perry about their study, Female-Biased Vascular Smooth Muscle Cell Gene Regulatory Networks Predict MYH9 as a Key Regulator of Fibrous Plaque Phenotype.

Article highlights:

Westhoff, et al. PTEN and PIP3 in AngII-Induced Cardiac Pathology

Witmer, et al. Novel Mode of SCN5A-Mitochondrial Crosstalk

Ghiringhelli, et al. Light-Controllable Humanized Bioengineered Atria

Wang, et al. Exercise-Induced Cardiomyocyte EVs Deliver EPPIR

This month on Episode 83 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the March 27th and April 10th issue of Circulation Research. This Episode also features a discussion with Dr Martin Schwartz and Dr Hanqiang Deng about their study, FOXO1 Integrates Endothelial Hemodynamic, Inflammatory, and Metabolic Pathways in Atherosclerosis.

Article highlights:

Tadokoro, et al. CRISPR Base Editing of PKCα Rescues Heart Failure

Joki, et al. PTH Affects Right Heart Hemodynamics

Compendium on Migration of Mitochondria Beyond Cell Boundary

This month on Episode 82 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the February 27th and March 13th issue of Circulation Research. This Episode also features a discussion with Dr John Hall and Dr Ana Omoto from the University of Mississippi Medical Center about their study, Leptin Activates Brain-BAT-Heart Crosstalk to Promote Cardiac Protection.

Article highlights:

Sakkers, et al. Atherosclerotic Fibrous Plaques in Women

Ruberto, et al. Mitochondrial Biogenesis and Heart Regeneration

Simon-Chica, et al. Non-Myocytes Modulate Atrial Fibrillation Dynamics

Zhao, et al. USP10 Inhibits cGAS-STING via MTX2

This month on Episode 81 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the January 30th and February 13th issue of Circulation Research. This Episode also features a discussion with Dr Claudia Goettsch and Nicolas Hense, about their study, 1-Phosphatidylinositol 3-Phosphate 5-Kinase Inhibition by Apilimod Promotes an Adipocyte-like Vascular Smooth Muscle Cell Phenotype and Prevents Arterial Calcification.

Article highlights:

Hu, et al. CircZBTB44 Inhibits Calcific Aortic Valve Disease

Schemelei, et al. Olfr2 Aggravates AAA Formation

Zhang, et al. Neratinib Protects Against Atherosclerosis

Sun, et al. CD34+ Cells in Transplants

This month on Episode 80 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the January 2nd and January 16th issue of Circulation Research. This Episode also features a discussion with Dr Colin Evans and Dr You-Yang Zhao about their study, The Unexpected Protective Role of Thrombosis in Lung Injury via Endothelial ALOX15.

Article highlights:

Viskadourou, et al. Endothelial REST in Atherosclerosis

Torre, et al. Silencing the Chronotropic Heart Rate Response

Chen, et al. Histone Lactylation and Cardiac Hypertrophy

Vázquez-Reyes, et al. Diurnal Neutrophil Function Drives Stroke Outcome

This month on Episode 79 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the December 5th issue of Circulation Research. This Episode also features a discussion with Dr Nobuaki Fukuma and Dr Emily Tsai from Columbia University Vagelos College of Physicians and Surgeons about their study, Cardiomyocyte GC1 Mediates Estrogenic Angiogenesis in Right Heart Remodeling.

Article highlights:

Hamilton, et al. RyR2 Hyperactivity Remodels Mitochondria

Singhal, et al. TRIB3 Activation Impairs Efferocytosis

Tsai, et al. YAP Induces Glycolysis to Drive Fibroinflammation