This month on Episode 74 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the June 20th and July 4th issues of Circulation Research. This Episode also features a discussion with the finalists for the 2025 BCVS Outstanding Early Career Investigator Award.

Article highlights:

Kimura, et al. Novel Genetic Mouse Model of Aortic Dissection

Getaneh, et al. Aspirin Non-Responsiveness in Preeclampsia

Introduction to the Compendium on Cardiopulmonary Disease and Exercise: Molecular to Clinical Mechanisms

This month on Episode 73 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the May 23rd and June 6th issues of Circulation Research. This Episode also includes a discussion with Dr Jae Min Cho and Tzung Hsiai, about their study, Habitual Exercise Modulates Neuroimmune Interaction to Mitigate Aortic Stiffness.

Article highlights:

Interorgan Crosstalk in Heart Failure and Cardiometabolic Diseases: A Compendium

He, et al. NEP in Placental EVs Triggers Hypertension in PE

Dennis, et al. FoxO1-zDHHC4-CD36 S-Acylation Axis in Diabetes

This month on Episode 72 of Discover CircRes, host Cindy St. Hilaire highlights four articles featured in the April 25th and May 9th issues of Circulation Research. This Episode also includes a discussion with Dr Sarah Costantino and Dr Francesco Paneni from University Hospital Zurich about their study, Chromatin Rewiring by SETD2 Drives Lipotoxic Injury in Cardiometabolic HFpEF

Article highlights:

Laudette, et al. PCSK9 and Mitochondrial Cholesterol in Heart

Yang, et al. Srsf3 Limits AS by Lengthening 3′ UTRs of mtARSs

Li, et al.  CircCDYL Contributes to Cardiac Hypertrophy

Zhakeer, et al. Treg Cells Regulate Pulmonary Venous Remodeling

This month on Episode 71 of Discover CircRes, host Cindy St. Hilaire highlights three articles featured in the March 28th and April 11th issues of Circulation Research. This Episode also includes a discussion with Dr Magali Noval Rivas and Dr Prasant Jena from Cedars-Sinai Medical Center about their study, Intestinal Microbiota Contributes to the Development of Cardiovascular Inflammation and Vascular in Mice.

Article highlights:

Han, et al. PRL2 Dephosphorylates AMPKα2 in Heart

Perelli, et al. TAX1BP3 and Arrhythmogenic Cardiomyopathy

Lalaguna, et al. Overexpression of Wild Type TMEM43 Improves ARVC5

Liu, et al. NR4A1 Inhibits Platelet Function

This month on Episode 70 of Discover CircRes, host Cindy St. Hilaire highlights three articles featured in the February 28th issue of Circulation Research and the Compendium on Lifelong Care in Women: Applying a Sex- and Gender-Lens to Practice in the March 14th issue. This Episode also includes a discussion with Dr Matt Rossman and Sanna Darvish from the University of Colorado, Boulder about their study, Preservation of Vascular Endothelial Function in Late Onset Postmenopausal Women.

Article highlights:

Huang, et al. Targeting CXCR3 in ICI-Mediated Myocarditis

Ju, et al. RIC-Enhanced Efferocytosis on Stroke Recovery

Halmos, et al. Cholesterol Efflux Pathways Control SMC Function

Compendium on Lifelong Care in Women: Applying a Sex- and Gender-Lens to Practice

This month on Episode 69 of Discover CircRes, host Cindy St. Hilaire highlights four articles featured in the January 31st and February 14th issues of Circulation Research. This Episode also includes a discussion with Dr Frank Conlon and graduate student Ike Emerson about their study, X Chromosome-Linked MicroRNAs Regulate Sex Differences in Cardiac Physiology.

Article highlights:

Huang, et al. Vps4a Safeguards Plasma Membrane Integrity

Liu, et al. PPM1B Deubiquitination Promotes Arterial Stiffness

Muralitharan, et al. GPR41/43 and Blood Pressure

Park, et al. Ferroptosis and Its Consequences in Preeclampsia

This month on Episode 68 of Discover CircRes, host Cindy St. Hilaire highlights four articles featured in the January 3rd and January 17th issues of Circulation Research. This Episode also includes a discussion with Drs Gianluigi Condorelli and Marinos Kallikourdis about their study Autoimmune-like Mechanism in Heart Failure Enables Preventative Vaccine Therapy.

Article highlights:

Yoshida, et al. FAP Vaccine Improves Cardiac Fibrosis

Johansen, et al. TCF21 and Cardiac Fibrosis

Pabon, et al. Endothelial METAP1 in Preeclampsia

Mutchler, et al. ET-3/ETBR, Immune Cells, and Kidney Lymphatics

This month on Episode 67 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the December 6th issues of Circulation Research. This Episode also includes a discussion with Drs Jesse Rowley and Shancy Jacob about their study, Mitofusin-2 Regulates Platelet Mitochondria and Function.

Article highlights:

Bardhan, et al. Sex Specific Roles of Microbiota in Hypertension

Ma, et al. Kindlin-2 LLPS Controls Vascular Stability

Wang, et al. CAR-Ms Alleviate Myocardial I/R Injury

This month on Episode 66 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the October 25th and November 8th issues of Circulation Research. This Episode also includes a discussion with Dr Jil Tardiff and Dr Melissa Lynn about their study, Arg92Leu-cTnT Alters the cTnC-cTnI Interface Disrupting PKA-Mediated Relaxation.

Article highlights:

Lou, et al. Visualizing irAEs in Atherosclerosis

Yoshii, et al. Defective Mitophagy Response in HFpEF Heart

Zeller, et al. Shear Stress Dissociates C-Reactive Protein

Chen, et al. EPHB4-RASA1 Regulation of Lymphatic Valvulogenesis

This month on Episode 65 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the September 27th and October 11th issues of Circulation Research. This Episode also includes a discussion with Dr Ken Walsh and Dr Ariel Polizio about their study, Experimental TET2 Clonal Hematopoiesis Predisposes to Renal Hypertension Through an Inflammasome-Mediated Mechanism.

Article highlights:

Ju, et al. NAE1 Crotonylation Regulates Cardiac Hypertrophy

Pirri, et al. EPAS1 Atheroprotection via Fatty Acid Metabolism

Saleem, et al. Myeloid CD11c+ Cells and JAK2/STAT3/SMAD3 in SSBP

Pietsch, et al. Chronic Activation of Tubulin Tyrosination