This month on Episode 79 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the December 5th issue of Circulation Research. This Episode also features a discussion with Dr Nobuaki Fukuma and Dr Emily Tsai from Columbia University Vagelos College of Physicians and Surgeons about their study, Cardiomyocyte GC1 Mediates Estrogenic Angiogenesis in Right Heart Remodeling.

Article highlights:

Hamilton, et al. RyR2 Hyperactivity Remodels Mitochondria

Singhal, et al. TRIB3 Activation Impairs Efferocytosis

Tsai, et al. YAP Induces Glycolysis to Drive Fibroinflammation

This month on Episode 78 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the October 24th and November 7th issues of Circulation Research. This Episode also features a discussion with Thomas Hund and Drew Nassal from the Ohio State University about their study, The βIV-Spectrin/STAT3 Complex Regulates the Orientation of Cardiac Hypertrophic Growth.

Article highlights:

Dhawan, et al. Macrophage DNases Clear Tissue NETs

Pakkiriswami, et al. LV and RV Responses to Elevated Mitochondrial Ca2+

Liu, et al. CCL21 Enhances Platelet Activation

Morales, et al. Vascular Niches and Cardiac Aging

This month on Episode 76 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the August 29th and September 12th issues of Circulation Research. This Episode also features a discussion with Drs Swapnil Sonkusare and Mani Kuppusamy about their manuscript, Paracrine Smooth Muscle-to-Endothelial Signaling via TNF Elevates Blood Pressure in Obesity.

Article highlights:

Tombor, et al. Immunomodulatory Endothelial Cells After Heart Attack

Du, et al. CAR-Ms Engineered In Vivo for Attenuating MIRI

Pauza, et al. MC4R Activates Carotid Body in Hypertension

Cai, et al. Lkb1 KO in PVAT Drives Aortic Aneurysm Formation

This month on Episode 75 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the August 1st and August 15th issues of Circulation Research. This Episode also features a discussion with Abigail Ajanel, Dr Robbie Campbell and Dr Frederik Denorme about their study, Mitochondrial Calcium Uniporter Regulates ITAM-Dependent Platelet Activation.

Article highlights:

Lan, et al. TRIM16 Exacerbates Vascular Calcification

Zhang, et al. HADHA Lactylation in Septic Myocardial Depression

Li, et al. AR Links to CVMs

Baudel, et al. Vascular Panx1 in Diabetic Hyperglycemia

This month on Episode 74 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the June 20th and July 4th issues of Circulation Research. This Episode also features a discussion with the finalists for the 2025 BCVS Outstanding Early Career Investigator Award.

Article highlights:

Kimura, et al. Novel Genetic Mouse Model of Aortic Dissection

Getaneh, et al. Aspirin Non-Responsiveness in Preeclampsia

Introduction to the Compendium on Cardiopulmonary Disease and Exercise: Molecular to Clinical Mechanisms

This month on Episode 73 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the May 23rd and June 6th issues of Circulation Research. This Episode also includes a discussion with Dr Jae Min Cho and Tzung Hsiai, about their study, Habitual Exercise Modulates Neuroimmune Interaction to Mitigate Aortic Stiffness.

Article highlights:

Interorgan Crosstalk in Heart Failure and Cardiometabolic Diseases: A Compendium

He, et al. NEP in Placental EVs Triggers Hypertension in PE

Dennis, et al. FoxO1-zDHHC4-CD36 S-Acylation Axis in Diabetes

This month on Episode 72 of Discover CircRes, host Cindy St. Hilaire highlights four articles featured in the April 25th and May 9th issues of Circulation Research. This Episode also includes a discussion with Dr Sarah Costantino and Dr Francesco Paneni from University Hospital Zurich about their study, Chromatin Rewiring by SETD2 Drives Lipotoxic Injury in Cardiometabolic HFpEF

Article highlights:

Laudette, et al. PCSK9 and Mitochondrial Cholesterol in Heart

Yang, et al. Srsf3 Limits AS by Lengthening 3′ UTRs of mtARSs

Li, et al. CircCDYL Contributes to Cardiac Hypertrophy

Zhakeer, et al. Treg Cells Regulate Pulmonary Venous Remodeling

This month on Episode 71 of Discover CircRes, host Cindy St. Hilaire highlights three articles featured in the March 28th and April 11th issues of Circulation Research. This Episode also includes a discussion with Dr Magali Noval Rivas and Dr Prasant Jena from Cedars-Sinai Medical Center about their study, Intestinal Microbiota Contributes to the Development of Cardiovascular Inflammation and Vascular in Mice.

Article highlights:

Han, et al. PRL2 Dephosphorylates AMPKα2 in Heart

Perelli, et al. TAX1BP3 and Arrhythmogenic Cardiomyopathy

Lalaguna, et al. Overexpression of Wild Type TMEM43 Improves ARVC5

Liu, et al. NR4A1 Inhibits Platelet Function

This month on Episode 70 of Discover CircRes, host Cindy St. Hilaire highlights three articles featured in the February 28th issue of Circulation Research and the Compendium on Lifelong Care in Women: Applying a Sex- and Gender-Lens to Practice in the March 14th issue. This Episode also includes a discussion with Dr Matt Rossman and Sanna Darvish from the University of Colorado, Boulder about their study, Preservation of Vascular Endothelial Function in Late Onset Postmenopausal Women.

Article highlights:

Huang, et al. Targeting CXCR3 in ICI-Mediated Myocarditis

Ju, et al. RIC-Enhanced Efferocytosis on Stroke Recovery

Halmos, et al. Cholesterol Efflux Pathways Control SMC Function

Compendium on Lifelong Care in Women: Applying a Sex- and Gender-Lens to Practice