An excerpt from Jacob Krueger's podcast: 

"... So learning how to write a successful screenplay is not actually just about learning how to write a good screenplay, it's learning how to know what compromises you can make and what compromises you cannot. Which imperfections your audience will accept, which imperfections are going to pull them out of the story.

In many ways, the success or failure of your movie all boils down to one really simple concept: Feeding The Genre Monster."