Dr. Howard Smith Reports

Vidcast:  https://youtu.be/Cy37zQuJfpA

A designer vaccine that presents mutated forms of Covid spike proteins to the immune system on nanoparticles induces powerful antibodies to the 3 current variants, the British B.1.1.7, the South African B.1.351, and the Brazilian P.1.  Immunologists at San Diego’s Scripps Institute now report this achievement as a promising solution to our current CoVid variant challenge.

Nanoparticle-mounted CoVid spike proteins more efficiently induce a broader range of virus killing antibodies compared with vaccines that present CoVid proteins in solution.  Why? Longer retention of the nanoparticle-bound antigens within lymph nodes and better presentation of the antigens to antibody-producing lymphocytes.

This technology is very welcome news.

https://www.biorxiv.org/content/10.1101/2021.03.26.437274v1.full.pdf+html

#CoVid #vaccine #nanotechnology #variants

Vidcast:  https://youtu.be/Cy37zQuJfpA

A designer vaccine that presents mutated forms of Covid spike proteins to the immune system on nanoparticles induces powerful antibodies to the 3 current variants, the British B.1.1.7, the South African B.1.351, and the Brazilian P.1.  Immunologists at San Diego’s Scripps Institute now report this achievement as a promising solution to our current CoVid variant challenge.

Nanoparticle-mounted CoVid spike proteins more efficiently induce a broader range of virus killing antibodies compared with vaccines that present CoVid proteins in solution.  Why? Longer retention of the nanoparticle-bound antigens within lymph nodes and better presentation of the antigens to antibody-producing lymphocytes.

This technology is very welcome news.

https://www.biorxiv.org/content/10.1101/2021.03.26.437274v1.full.pdf+html

#CoVid #vaccine #nanotechnology #variants

Vidcast:  https://youtu.be/a59K_yqb1ZU

Exercising during your off-hours can reduce your chances of death by as much as 40%.  Ironically, though, high physical exertion at work actually increases your death risk by 27%.  Danish researchers present these conclusions after studying the mortality data from a cohort of 104,046 Danes and tabulating it with self-reported physical activity during leisure time and at work.

Compared with those reporting little leisure activity, those with moderate and high or very high physical exertion experienced 26% and 40% reduced risks of death from coronary events and stroke.  Work activity was unhelpful, and those with high and very high exertion at work were 13% and 27% more likely to die.

https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehab087/6213772

#exercise #leisuretime #work #mortality 

Vidcast:  https://youtu.be/a59K_yqb1ZU

Exercising during your off-hours can reduce your chances of death by as much as 40%.  Ironically, though, high physical exertion at work actually increases your death risk by 27%.  Danish researchers present these conclusions after studying the mortality data from a cohort of 104,046 Danes and tabulating it with self-reported physical activity during leisure time and at work.

Compared with those reporting little leisure activity, those with moderate and high or very high physical exertion experienced 26% and 40% reduced risks of death from coronary events and stroke.  Work activity was unhelpful, and those with high and very high exertion at work were 13% and 27% more likely to die.

https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehab087/6213772

#exercise #leisuretime #work #mortality 

Vidcast:  https://youtu.be/Wd06crfQLUM

New treatments for Alzheimer’s, sickle cell disease, concussions, organ replacement, wound healing, and color blindness.  All this on  Medicine of the Future.

My reports typically cover research discoveries that you can use here and now.  This new feature, Medicine Of The Future, gives you an inkling of what’s to come in future medical and surgical therapeutics.

A small molecule discovered by University of Arizona researchers regulates cholesterol levels in the brain and may become part of new therapy for Alzheimer’s disease.  ABCA1 is that molecule and increasing it reduces dementia-producing brain inflammation.  The team found another small molecule CL2-57 that bumps up ABCA1 production and it could become Alzheimer therapy.

The Cambridge, MA biopharmaceutical company Fulcrum Therapeutics is developing a pill to treat the root cause of sickle cell disease.  Their oral drug FTX-6058 triggers the production of fetal-type hemoglobin within red cells and prevents them from deforming and clogging blood vessels while permitting treated red cells to carry a nearly normal amount of oxygen.

Your spit may soon tell doctors if you’ve had a concussion.  British investigators studying rugby players have discovered  biomarkers in saliva that signal a traumatic brain injury.  Tests to detect these markers are under development by  a Swiss company Marker Diagnostics and will have broad application for general, sports, and military medicine.

Speaking of concussion, birth control pills with progesterone might help female athletes weather them better.  Northwestern University neuroscientists find that higher progesterone levels help women recover faster from concussion by increasing brain blood flow and reducing stress levels.  

Swedish researchers report a new bioink for improved 3D printing of human tissues.  This next generation bioink permits fabrication of tissue scaffolds that support development of both the airways and blood vessels. These structures are a must for the printing of vital organs such as lungs. 

Ohio State bioengineers report that applying tiny direct current electric fields to traumatized tissues permits a favorable 4 fold blood vessel permeability increase that speeds wound healing.  Increased blood vessel permeability allows vital nutrients to flow into tissues as they repair themselves.

Engineers at Abu Dhabi’s Khalifa University have developed tinted contact lenses that treat color blindness.  These rose-tinted contact lenses are constructed of gold nanoparticles in a hydrogel polymer.   They selectively filter light within a 520-580 nm wavelength range permitting improved red-green shade discrimination.

These and other cutting edge solutions are coming to your doctor’s office and our hospitals…….some day soon!

https://pubs.acs.org/doi/10.1021/acsptsci.0c00149

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Vidcast:  https://youtu.be/Wd06crfQLUM

New treatments for Alzheimer’s, sickle cell disease, concussions, organ replacement, wound healing, and color blindness.  All this on  Medicine of the Future.

My reports typically cover research discoveries that you can use here and now.  This new feature, Medicine Of The Future, gives you an inkling of what’s to come in future medical and surgical therapeutics.

A small molecule discovered by University of Arizona researchers regulates cholesterol levels in the brain and may become part of new therapy for Alzheimer’s disease.  ABCA1 is that molecule and increasing it reduces dementia-producing brain inflammation.  The team found another small molecule CL2-57 that bumps up ABCA1 production and it could become Alzheimer therapy.

The Cambridge, MA biopharmaceutical company Fulcrum Therapeutics is developing a pill to treat the root cause of sickle cell disease.  Their oral drug FTX-6058 triggers the production of fetal-type hemoglobin within red cells and prevents them from deforming and clogging blood vessels while permitting treated red cells to carry a nearly normal amount of oxygen.

Your spit may soon tell doctors if you’ve had a concussion.  British investigators studying rugby players have discovered  biomarkers in saliva that signal a traumatic brain injury.  Tests to detect these markers are under development by  a Swiss company Marker Diagnostics and will have broad application for general, sports, and military medicine.

Speaking of concussion, birth control pills with progesterone might help female athletes weather them better.  Northwestern University neuroscientists find that higher progesterone levels help women recover faster from concussion by increasing brain blood flow and reducing stress levels.  

Swedish researchers report a new bioink for improved 3D printing of human tissues.  This next generation bioink permits fabrication of tissue scaffolds that support development of both the airways and blood vessels. These structures are a must for the printing of vital organs such as lungs. 

Ohio State bioengineers report that applying tiny direct current electric fields to traumatized tissues permits a favorable 4 fold blood vessel permeability increase that speeds wound healing.  Increased blood vessel permeability allows vital nutrients to flow into tissues as they repair themselves.

Engineers at Abu Dhabi’s Khalifa University have developed tinted contact lenses that treat color blindness.  These rose-tinted contact lenses are constructed of gold nanoparticles in a hydrogel polymer.   They selectively filter light within a 520-580 nm wavelength range permitting improved red-green shade discrimination.

These and other cutting edge solutions are coming to your doctor’s office and our hospitals…….some day soon!

https://pubs.acs.org/doi/10.1021/acsptsci.0c00149

https://www.sciencedaily.com/releases/2021/04/210409093609.htm

https://bjsm.bmj.com/content/early/2021/02/09/bjsports-2020-103274

https://www.liebertpub.com/doi/10.1089/neu.2020.7217

https://onlinelibrary.wiley.com/doi/10.1002/adma.202005476

https://pubs.rsc.org/en/content/articlelanding/2021/LC/D0LC00507J#!divAbstract

https://pubs.acs.org/doi/10.1021/acsnano.0c09657

#Alzheimer #sicklecell #concussion #organreplacement #woundhealing #colorblindness

Vidcast:  https://youtu.be/bBtAEoEUjYY

The FDA and Glutenull Bakery recall Glutenull Goji Berries and Chocolate Cookies.  These cookies contain undeclared milk.  Those with a milk allergy may develop a severe or life-threatening allergic reaction after ingesting these cookies.  If you bought these cookies, return them to the place of purchase for a full refund. If you have questions contact Glutenull Bakery at 1-604-777-5596.

https://www.fda.gov/safety/recalls-market-withdrawals-safety-alerts/glutenull-bakery-issues-allergy-alert-undeclared-milk-goji-berries-and-chocolate-cookies

#cookies #glutenull #milk #recall

Vidcast:  https://youtu.be/bBtAEoEUjYY

The FDA and Glutenull Bakery recall Glutenull Goji Berries and Chocolate Cookies.  These cookies contain undeclared milk.  Those with a milk allergy may develop a severe or life-threatening allergic reaction after ingesting these cookies.  If you bought these cookies, return them to the place of purchase for a full refund. If you have questions contact Glutenull Bakery at 1-604-777-5596.

https://www.fda.gov/safety/recalls-market-withdrawals-safety-alerts/glutenull-bakery-issues-allergy-alert-undeclared-milk-goji-berries-and-chocolate-cookies

#cookies #glutenull #milk #recall

Vidcast:  https://youtu.be/8GhENG8rW9Y

The CPSC and RH are recalling RH Animal, Heathered Plush and Luxe Sherpa Children’s Bath Wraps.  These bath wraps fail to meet flammability standards for children’s sleepwear and pose a risk of burn injuries to children.  About 55,700 were sold in the US and about 3,900 units were sold in Canada through RH Baby & Child Galleries and RH Outlets and online at www.rh.com and www.rhbabyandchild.com.  If you have these wraps, stop using them for your child and call RH at 1-833-917-3405 to arrange for a refund.

https://www.cpsc.gov/Recalls/2021/RH-Recalls-Childrens-Bath-Wraps-Due-to-Violation-of-Federal-Flammability-Standard

#bathwrap #rh #flammable #fire #burns #recall

Vidcast:  https://youtu.be/8GhENG8rW9Y

The CPSC and RH are recalling RH Animal, Heathered Plush and Luxe Sherpa Children’s Bath Wraps.  These bath wraps fail to meet flammability standards for children’s sleepwear and pose a risk of burn injuries to children.  About 55,700 were sold in the US and about 3,900 units were sold in Canada through RH Baby & Child Galleries and RH Outlets and online at www.rh.com and www.rhbabyandchild.com.  If you have these wraps, stop using them for your child and call RH at 1-833-917-3405 to arrange for a refund.

https://www.cpsc.gov/Recalls/2021/RH-Recalls-Childrens-Bath-Wraps-Due-to-Violation-of-Federal-Flammability-Standard

#bathwrap #rh #flammable #fire #burns #recall