Dr. Howard Smith Reports

Vidcast:  https://youtu.be/2RYVDOo7gA8

If you had CoVid, there is still a 1 in 10 chance of reinfection.  Researchers at New York’s Mount Sinai Hospital followed 2,346 predominately male Marines 18-20 years of age over a 6 month study period.  Those entering the study with CoVid antibodies were considered to have been infected.

Ten percent became reinfected.  The reinfected had significantly lower anti-CoVid antibody levels as the result of their first infections.  The reinfected were predominately (84%) asymptomatic, but they harbored sufficient virus to infect others.

Even if you had CoVid, get the vaccine since your natural infection produces insufficient protective antibodies.  Studies show that you need only a single dose.

https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(21)00158-2/fulltext

#CoVid #reinfection #antibodies #vaccine

Vidcast:  https://youtu.be/2RYVDOo7gA8

If you had CoVid, there is still a 1 in 10 chance of reinfection.  Researchers at New York’s Mount Sinai Hospital followed 2,346 predominately male Marines 18-20 years of age over a 6 month study period.  Those entering the study with CoVid antibodies were considered to have been infected.

Ten percent became reinfected.  The reinfected had significantly lower anti-CoVid antibody levels as the result of their first infections.  The reinfected were predominately (84%) asymptomatic, but they harbored sufficient virus to infect others.

Even if you had CoVid, get the vaccine since your natural infection produces insufficient protective antibodies.  Studies show that you need only a single dose.

https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(21)00158-2/fulltext

#CoVid #reinfection #antibodies #vaccine

Vidcast:  https://youtu.be/psC1lsiDV8k

Being overweight but also underweight boosts a woman’s risk of suffering recurrent pregnancy losses by 20%.  British obstetricians performed a focused meta-analysis of 16 published studies covering nearly 66,000 women.

Repeated miscarriages are 21% more likely in women with BMI’s >25 than those with normal body weight.  In those with repeated losses, having a BMI greater than 30 bumps up the risk of additional miscarriages to 77%.  Those with BMIs under 18, were 20% more likely to have repeat losses, particularly if they were underweight between the ages of 18 and 20.

Smoking, drinking, coffee, stress, and night shifts had no significant effects on recurrent miscarriages.

Pregnant women should weigh daily and adjust intake accordingly.

https://www.nature.com/articles/s41598-021-86445-2

#miscarriage #overweight #underweight

Vidcast:  https://youtu.be/psC1lsiDV8k

Being overweight but also underweight boosts a woman’s risk of suffering recurrent pregnancy losses by 20%.  British obstetricians performed a focused meta-analysis of 16 published studies covering nearly 66,000 women.

Repeated miscarriages are 21% more likely in women with BMI’s >25 than those with normal body weight.  In those with repeated losses, having a BMI greater than 30 bumps up the risk of additional miscarriages to 77%.  Those with BMIs under 18, were 20% more likely to have repeat losses, particularly if they were underweight between the ages of 18 and 20.

Smoking, drinking, coffee, stress, and night shifts had no significant effects on recurrent miscarriages.

Pregnant women should weigh daily and adjust intake accordingly.

https://www.nature.com/articles/s41598-021-86445-2

#miscarriage #overweight #underweight

Vidcast: https://youtu.be/_HW1iHftI3o

New developments for:  

Skin Cancer, Pancreatic Cancer, Stroke, Pediatric Heart Disease, Male Contraception, Genetic Engineering

All this on  Medicine of the Future.

Researchers at the Ohio State Comprehensive  Cancer Center suggest that the already available and inexpensive neurodrug dopamine can reduce the development of common skin cancers including basal cell and squamous cell carcinomas. Testing this drug in mice, it stimulates receptors in the cell that block the cancer-inducing effects of ultraviolet light.  The drug could be a godsend for those with light-complexions and a propensity for skin cancer

University of Pennsylvania oncologists report a preliminary phase 1 study of a drug that drives killer T cells into notoriously treatment-resistant pancreatic cancer.  The drug selicrelumab was given to 15 patients before their surgery and chemotherapy.  The excised tumor specimens were T-cell enriched and less fibrotic permitting better penetration of other therapeutic agents.  The treated group lived nearly twice as long.

mRNA delivered to brain tissues can induce an agent that protects during a stroke.  Tokyo neuroscientists and bioengineers developed mRNA in a polymer nanoball that codes for BDNF, brain-derived neurotrophic factor, that enhances the survival of neurons deprived of oxygen during a stroke.  The best news is that the mRNA treatment works well even if given 2 to 5 days after the neuro-catastrophic stroke.

University of Minnesota bioengineers have created pediatric heart valve replacements that can grow with their young recipients.  The researchers constructed valved conduits made from fibroblast-derived collagen that grew with the recipient lambs.  These valves revealed good function up to a year after implantation and developed less calcification than conventional bioprosthetic valves.

A Chinese herbal compound, triptonide, given orally can reduce sperm motility producing consistent yet reversible male infertility after 6 weeks of therapy.  Collaborators at the University of Nevada and UCLA developed and tested this compound which may well be the first practical non-hormonal male contraceptive.  Triptonide blocks the last steps of sperm assembly and may be purified from the Chinese herb or directly synthesized.

Wearable technology is on the rise, and many smart sensors may require wearable antennas to transmit that data for processing.  Such antennas must be able to twist, compress, and stretch.  Bioengineers at Penn State in collaboration with China’s Hebei University of Technology have now developed a layered copper mesh antenna with transmission properties minimally affected by geometric changes.

Genetic engineering, the ability to treat diseases by modifying a human’s cellular genetic makeup takes two giant steps forward.  First…….Geneticists at UC-San Francisco announce a modification to the epic CRISPR-CAS genetic editing technique that permits controlling expression of given genes without modifying the core cellular DNA.  This technique, called CRISPRoff, can modify epigenetic material in

Vidcast: https://youtu.be/_HW1iHftI3o

New developments for:  

Skin Cancer, Pancreatic Cancer, Stroke, Pediatric Heart Disease, Male Contraception, Genetic Engineering

All this on  Medicine of the Future.

Researchers at the Ohio State Comprehensive  Cancer Center suggest that the already available and inexpensive neurodrug dopamine can reduce the development of common skin cancers including basal cell and squamous cell carcinomas. Testing this drug in mice, it stimulates receptors in the cell that block the cancer-inducing effects of ultraviolet light.  The drug could be a godsend for those with light-complexions and a propensity for skin cancer

University of Pennsylvania oncologists report a preliminary phase 1 study of a drug that drives killer T cells into notoriously treatment-resistant pancreatic cancer.  The drug selicrelumab was given to 15 patients before their surgery and chemotherapy.  The excised tumor specimens were T-cell enriched and less fibrotic permitting better penetration of other therapeutic agents.  The treated group lived nearly twice as long.

mRNA delivered to brain tissues can induce an agent that protects during a stroke.  Tokyo neuroscientists and bioengineers developed mRNA in a polymer nanoball that codes for BDNF, brain-derived neurotrophic factor, that enhances the survival of neurons deprived of oxygen during a stroke.  The best news is that the mRNA treatment works well even if given 2 to 5 days after the neuro-catastrophic stroke.

University of Minnesota bioengineers have created pediatric heart valve replacements that can grow with their young recipients.  The researchers constructed valved conduits made from fibroblast-derived collagen that grew with the recipient lambs.  These valves revealed good function up to a year after implantation and developed less calcification than conventional bioprosthetic valves.

A Chinese herbal compound, triptonide, given orally can reduce sperm motility producing consistent yet reversible male infertility after 6 weeks of therapy.  Collaborators at the University of Nevada and UCLA developed and tested this compound which may well be the first practical non-hormonal male contraceptive.  Triptonide blocks the last steps of sperm assembly and may be purified from the Chinese herb or directly synthesized.

Wearable technology is on the rise, and many smart sensors may require wearable antennas to transmit that data for processing.  Such antennas must be able to twist, compress, and stretch.  Bioengineers at Penn State in collaboration with China’s Hebei University of Technology have now developed a layered copper mesh antenna with transmission properties minimally affected by geometric changes.

Genetic engineering, the ability to treat diseases by modifying a human’s cellular genetic makeup takes two giant steps forward.  First…….Geneticists at UC-San Francisco announce a modification to the epic CRISPR-CAS genetic editing technique that permits controlling expression of given genes without modifying the core cellular DNA.  This technique, called CRISPRoff, can modify epigenetic material in the nucleus that silences a gene and prevents its production of proteins.  This change is inherited.

In a second development……..As useful as CRISPR-CAS  gene editing may be, Carnegie Mellon biochemists announce a new peptide nucleic acid-based or PNA-based system that does what CRISPR can’t.  PNA editing can modify cells in a living animal while CRISPR edits cells removed from the body.  The PNA-donor DNA in a nanoparticle package can’t modify as many cells at one time as CRISPR, but it appears more precise with fewer off-target DNA modifications.

These and other cutting edge solutions are coming to your doctor’s office and our hospitals…….some day soon!

https://cancerpreventionresearch.aacrjournals.org/content/early/2021/04/08/1940-6207.CAPR-21-0052

https://www.sciencedaily.com/releases/2021/04/210411114048.htm

https://stm.sciencemag.org/content/13/585/eabb7225

https://www.nature.com/articles/s41467-021-21517-5

https://www.sciencedirect.com/science/article/abs/pii/S0142961221000326?via%3Dihub

https://www.sciencedirect.com/science/article/pii/S0264127521002732?via%3Dihub

https://www.cell.com/cell/fulltext/S0092-8674(21)00353-6?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867421003536%3Fshowall%3Dtrue

https://www.nature.com/articles/s41586-021-03191-1

#SkinCancer #PancreaticCancer #Stroke #PediatricHeartDisease #MaleContraception  #GeneticEngineering

Vidcast:  https://youtu.be/m7jdzPxXCOY

The CPSC and Black Diamond now recall PIEPS DSP Pro, DSP Pro Ice, and DSP Sport Avalanche Transceivers.  This transceiver can switch modes when not locked or installed in the harness preventing it from transmitting a signal and making it difficult to locate a skier in an avalanche.  That can result in severe illness or death.  About 66,100 were sold in the US and about 12,500 were sold in Canada.  Immediately stop using this recalled avalanche transceiver and contact Black Diamond for a free replacement hardcase carrying system and user guide.  For more information, call Black Diamond at 1-866-306-0865.

https://www.cpsc.gov/Recalls/2021/Black-Diamond-Recalls-PIEPS-DSP-Avalanche-Transceivers-Due-to-Risk-of-Loss-of-Emergency-Communications-One-Death-Reported

#avalanche #transceiver #blackdiamond #pieps #death #recall

Vidcast:  https://youtu.be/m7jdzPxXCOY

The CPSC and Black Diamond now recall PIEPS DSP Pro, DSP Pro Ice, and DSP Sport Avalanche Transceivers.  This transceiver can switch modes when not locked or installed in the harness preventing it from transmitting a signal and making it difficult to locate a skier in an avalanche.  That can result in severe illness or death.  About 66,100 were sold in the US and about 12,500 were sold in Canada.  Immediately stop using this recalled avalanche transceiver and contact Black Diamond for a free replacement hardcase carrying system and user guide.  For more information, call Black Diamond at 1-866-306-0865.

https://www.cpsc.gov/Recalls/2021/Black-Diamond-Recalls-PIEPS-DSP-Avalanche-Transceivers-Due-to-Risk-of-Loss-of-Emergency-Communications-One-Death-Reported

#avalanche #transceiver #blackdiamond #pieps #death #recall

Vidcast:   https://youtu.be/MbPLfoKZbZE

The CPSC and Geo Essential now recall GEO Wintergreen Organic Essential Oil and GEO Alleviate Organic Essential Oil Blend.  These products contain methylsalicylate that is dangerous for children and must be sold in child-resistant packaging.  This product’s packaging is not.  Immediately stop use of this product and dispose of it.  You can also return it to the point of purchase for a refund.  For more information, call Geo Essential at 1-855-502-5363.

https://www.cpsc.gov/Recalls/2021/GEO-Essential-Recalls-Wintergreen-Organic-Essential-Oil-and-Alleviate-Organic-Essential-Oil-Blend-Due-to-Failure-to-Meet-Child-Resistant-Packaging-Requirement-Risk-of-Poisoning-Recall-Alert

#wintergreen #oils #methylsalicylate #packaging #recall

Vidcast:   https://youtu.be/MbPLfoKZbZE

The CPSC and Geo Essential now recall GEO Wintergreen Organic Essential Oil and GEO Alleviate Organic Essential Oil Blend.  These products contain methylsalicylate that is dangerous for children and must be sold in child-resistant packaging.  This product’s packaging is not.  Immediately stop use of this product and dispose of it.  You can also return it to the point of purchase for a refund.  For more information, call Geo Essential at 1-855-502-5363.

https://www.cpsc.gov/Recalls/2021/GEO-Essential-Recalls-Wintergreen-Organic-Essential-Oil-and-Alleviate-Organic-Essential-Oil-Blend-Due-to-Failure-to-Meet-Child-Resistant-Packaging-Requirement-Risk-of-Poisoning-Recall-Alert

#wintergreen #oils #methylsalicylate #packaging #recall