📘 New JAMA Review: Ovarian Cancer – From Symptoms to Survival 🌸

Approximately 21,000 women are diagnosed with ovarian cancer annually in the U.S.—and 80% present with advanced-stage disease.

The latest JAMA review by Caruso, Weroha, and Cliby (2025) offers a comprehensive update on:

🧬 Evolving genetic insights (BRCA1/2, HRD, Lynch)

🩺 Diagnostic strategies beyond CA-125

💊 State-of-the-art therapies: surgery, chemo, PARP inhibitors, bevacizumab

📉 Declining mortality trends due to prevention and early detection

With clear tables, evidence-based algorithms, and nuanced discussion on fertility-sparing surgery and maintenance therapy, this is a must-read for oncologists, gynecologists, and policy advocates alike.

#JAMA #OvarianCancer #WomensHealth #Oncology #BRCA #PARPinhibitors #GeneticTesting #CancerCare #GynecologicOncology #PrecisionMedicine

🚨 New Insights in Heart Failure Care! 🫀💉

A landmark meta-analysis in Nature Medicine shows that intravenous iron therapy significantly reduces heart failure hospitalizations and cardiovascular deaths — especially in the first year of treatment. 📉💪

With over 7,000 patients across 6 RCTs, this study reinforces IV iron as a safe, outcome-improving therapy in HFrEF with iron deficiency. 🔬✅

💡 Curious about TSAT, RR, or sex-specific effects? 📊 This is essential reading for cardiologists, internists, and heart failure teams

#HeartFailure #IronTherapy #Cardiology #EvidenceBasedMedicine #HFpEF #HFrEF #IVIron #MedicalEducation #ClinicalTrials #NatureMedicine

🚨 Spotlight on Medieval Thought! 🧠📜

Explore the legacy of Anselm of Canterbury—father of Scholasticism and originator of the Ontological Argument for God’s existence. His fusion of faith 🙏 and reason 🧩 shaped Western theology.

🎓 #Philosophy #MedievalStudies #Anselm #Theology

Tropical cyclones don’t just shake buildings — they shake hearts too.

A powerful multicountry study in Science Advances links 🌊 storm exposure to a 13% rise in cardiovascular hospitalizations, especially ischemic heart disease and stroke.

Vulnerable groups? Men, adults aged 20–59, and socioeconomically deprived communities.

🧠 The risk peaks ~2 months post-cyclone and lasts up to 6 months.

🧭 It’s time to rethink disaster response — beyond winds and water, to hearts and health equity.

#Cardiology #ClimateHealth #PublicHealth #DisasterPreparedness #GlobalHealth #CVD #Epidemiology #ClimateChange 🌍

🚗 42,939 lives lost in 2021 — the U.S. motor vehicle fatality rate remains far higher than other high-income nations.

The NEJM review on Motor Vehicle Crash Prevention highlights the Safe System Approach:

🛣️ Safer roads

🚘 Safer vehicles

👥 Safer people

⚡ Safer speeds

🚑 Better postcrash care

🔍 From graduated driver licensing to automated emergency braking (AEB) and driver-monitoring tech, the future of crash prevention lies in data, design, and shared responsibility.

Question: What innovations do you believe will move us closer to zero traffic deaths? 💡

#RoadSafety #PublicHealth #InjuryPrevention #SafeSystemApproach #NEJM #AutomotiveSafety

🎙️ New Podcast Episode!

“Hole in the Heart, Stroke on the Brain, Science at the Core” 🧠❤️🔬

Discover how a tiny opening—present in 1 in 4 adults—can lead to devastating strokes 🩺⚠️. We unpack the latest JAMA review on PFO, cryptogenic stroke, and how RoPE and PASCAL scores guide who benefits from closure. 🎯💉

🔗 Tune in to learn about cutting-edge trials, real-world risks, and how precision matters in stroke prevention.

#Stroke #PFO #Cardiology #Podcast #RoPE #PASCAL #ClinicalTrials #HeartBrainAxis #Neurocardiology #MedicalEducation 🎧📡

🧬 Just explored the largest GWAS on stuttering—over 1 million participants!

🎵 Fascinating link uncovered between impaired rhythm and speech disfluency, supporting the Atypical Rhythm Risk Hypothesis.

🧠 Genes like VRK2 and FANCL connect beat synchronization and stuttering risk.

🚀 A big step toward precision care in developmental speech disorders.

#Genetics #Stuttering #GWAS #Neurodevelopment #PrecisionMedicine #SpeechTherapy #RhythmAndSpeech

🎙️ From MRAs to ASIs: Rewriting Heart Failure’s Aldosterone Story

🚨 New Episode Alert! 🎧

Title: From MRAs to ASIs: Rewriting Heart Failure’s Aldosterone Story

💔🧬💊

In this episode of Got Knowledge Doc, we unpack the double-edged role of aldosterone in heart failure and kidney disease—from its genomic mischief to its nongenomic chaos via GPER.

We dive into:

✅ Why MRAs aren’t enough

🔬 What ASIs bring to the table

📉 How new trials like FIDELIO, FIGARO, and PREVENT-HF are shaping the future

If you treat heart failure, study hormones, or love precision medicine—this one’s for you.

🎧 Listen now and rethink the RAAS:

#HeartFailure #Aldosterone #CKD #Finerenone #ASIs #MRAs #RAAS #CardioRenal #Podcast #PrecisionMedicine #GPER

🚫💊➡️⚖️ The GLP-1 Comeback: Weight Regain After the Stop”

📊 Based on the 2025 BMC Medicine meta-analysis, we explore what happens after stopping anti-obesity meds like GLP-1 receptor agonists.

👀 Key takeaways:

– Weight regain begins as early as 8 weeks after stopping

– GLP-1 drugs show the highest rebound 📈

– Lifestyle changes alone may not prevent regain 🥗🏃‍♂️

– Long-term weight management may require long-term therapy 🔁

🎙️ Tune in to understand the science behind the yo-yo and what it means for clinical practice and patient counseling.

#ObesityCare #GLP1 #WeightRegain #PrecisionMedicine #Endocrinology #MetabolicHealth #MedicalPodcast 🎙️

🚨 Podcast Alert: “Move. Breathe. Beat AF 🏃‍♂️🫀💥”

The latest Cochrane systematic review + meta-analysis shows that exercise-based cardiac rehabilitation (ExCR) meaningfully reduces:

✅ AF recurrence

✅ Symptom severity

✅ AF burden and frequency

✅ And improves VO₂ peak & mental health—all without increased serious events.

📢 Time to rethink rhythm control—beyond the pill and catheter.

#AtrialFibrillation #Cardiology #ExerciseMedicine #CardioOncology #Rehabilitation #Podcast

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