Dr RR Baliga's "Got Knowledge Doc" Podkast

Oncometabolites and The Heart

Dr RR Baliga 'Got Knowledge Doc' PodKasts for Cardio-Oncologists

Baliga RR, Young JB. Energizing Diastole Heart Fail Clin. 2008;4(1):ix‐xiii.

Energizing Diastole

Sulkowski, P.L., Oeck, S., Dow, J. et al. Oncometabolites suppress DNA repair by disrupting local chromatin signalling. Nature (2020).

Tumour metabolites hinder DNA repair Krebs Cycle Nobel Lecture Ivosidenib and Cardiogenic Shock Oncometabolite d-2-hydroxyglutarate impairs α-ketoglutarate dehydrogenase and contractile function in rodent heart. Proc Natl Acad Sci U S A. D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice. Genes Dev. Changes in Citric Acid Cycle and Nucleoside Metabolism Are Associated with Anthracycline Cardiotoxicity in Patients with Breast Cancer. J Cardiovasc Transl Res. Krebs Cycle Primer Khan Academy

Taegtmeyer H, et al Oncometabolic Tracks in the Heart. Circ Res. 2017

🎧 Dr RR Baliga's Internal Medicine "Got Knowledge Doc" Podcasts for Physicians: MUST KNOW FACTs on Analysis of Acid-Base Disorders

from chapter titled

Acid-Base Disorders by John J Chang, MD & Aldo J Pexioto, MD

Yale University School of Medicine

in

Baliga's Textbook of Internal Medicine

www.MasterMedFacts.com

Not Medical Advice or Opinion

Yamanaka Factors

Dr RR Baliga's 'Got Knowledge Doc' Podkasts for Physicians

Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006 Aug 25;126(4):663-76. doi: 10.1016/j.cell.2006.07.024. Epub 2006 Aug 10. PMID: 16904174.

Sharma A. Stem cells to help the heart. Science. 2020 Mar 13;367(6483):1206. doi: 10.1126/science.aba6111. PMID: 32165579. Sayed N, Ameen M, Wu JC. Personalized medicine in cardio-oncology: the role of induced pluripotent stem cell. Cardiovasc Res. 2019 Apr 15;115(5):949-959. doi: 10.1093/cvr/cvz024. PMID: 30768178; PMCID: PMC6933506. Yoshida Y, Yamanaka S. Induced Pluripotent Stem Cells 10 Years Later: For Cardiac Applications. Circ Res. 2017 Jun 9;120(12):1958-1968. doi: 10.1161/CIRCRESAHA.117.311080. PMID: 28596174. Lu Y, Brommer B, Tian X, Krishnan A, Meer M, Wang C, Vera DL, Zeng Q, Yu D, Bonkowski MS, Yang JH, Zhou S, Hoffmann EM, Karg MM, Schultz MB, Kane AE, Davidsohn N, Korobkina E, Chwalek K, Rajman LA, Church GM, Hochedlinger K, Gladyshev VN, Horvath S, Levine ME, Gregory-Ksander MS, Ksander BR, He Z, Sinclair DA. Reprogramming to recover youthful epigenetic information and restore vision. Nature. 2020 Dec;588(7836):124-129. doi: 10.1038/s41586-020-2975-4. Epub 2020 Dec 2. PMID: 33268865. Litviňuková M, Talavera-López C, Maatz H, Reichart D, Worth CL, Lindberg EL, Kanda M, Polanski K, Heinig M, Lee M, Nadelmann ER, Roberts K, Tuck L, Fasouli ES, DeLaughter DM, McDonough B, Wakimoto H, Gorham JM, Samari S, Mahbubani KT, Saeb-Parsy K, Patone G, Boyle JJ, Zhang H, Zhang H, Viveiros A, Oudit GY, Bayraktar OA, Seidman JG, Seidman CE, Noseda M, Hubner N, Teichmann SA. Cells of the adult human heart. Nature. 2020 Sep 24:1–7. doi: 10.1038/s41586-020-2797-4. Epub ahead of print. PMID: 32971526; PMCID: PMC7681775.

Dr RR Baliga's Internal Medicine "Got Knowledge Doc" Podcasts for Physicians.

Not Medical Advice or opinion

🎧 Transthyretin (TTR) Amyloid: Dr RR Baliga "Got Knowledge Doc" PodKast for Physicians

1. Association of the V122I Hereditary Transthyretin Amyloidosis Genetic Variant With Heart Failure Among Individuals of African or Hispanic/Latino Ancestry Scott M. Damrauer, MD; Kumardeep Chaudhary, PhD; Judy H. Cho, MD; et al. JAMA. Dec10th, 2019;322(22):2191-2202. doi:10.1001/jama.2019.17935

2. Treatment of Cardiac Transthyretin Amyloidosis: Emdin M, Aimo A, Rapezzi C, et al. An Update. Eur Heart J 2019;40:3699-3706.

3. Treatment of Cardiac Transthyretin Amyloidosis Dec 13, 2019 | RR. Baliga, MD, FACC

Transthyretin (TTR) Amyloid: "Hot-off-the-Press Dr RR Baliga MUST KNOW FACTS PodKast"

1. Association of the V122I Hereditary Transthyretin Amyloidosis Genetic Variant With Heart Failure Among Individuals of African or Hispanic/Latino Ancestry Scott M. Damrauer, MD; Kumardeep Chaudhary, PhD; Judy H. Cho, MD; et al. JAMA. Dec10th, 2019;322(22):2191-2202. doi:10.1001/jama.2019.17935

2. Treatment of Cardiac Transthyretin Amyloidosis: An Update. Eur Heart J 2019;40:3699-3706.

3. Treatment of Cardiac Transthyretin Amyloidosis Dec 13, 2019 | RR. Baliga, MD, FACC

🎧 Dr RR Baliga's Internal Medicine "Got Knowledge Doc" Podcasts for Physicians: MUST KNOW FACTs about Acid and Base Physiology-A Simplified Version.

Not Medical Advice or Opinion

derived from the chapter

Acid-Base Disorders

by John J Chang, MD & Aldo J Peixoto, MD,

Yale University School of Medicine

in Baliga's Textbook of Internal Medicine with 1480 MCQs

www.MasterMedFacts.com

🎧 Dr RR Baliga's Internal Medicine "GOT KNOWLEDGE DOC" Podcasts for Physicians: MUST KNOW FACTs about Hypernatremia

Not Medical Advice or Opinion

Derived from a chapter titled

Electrolytes, authored by John J Chang, MD & Aldo J Pexioto, MD, from Yale University School of Medicine in

Baliga's Textbook of Internal Medicine with ~1480 Multiple Choice Questions.

www.MasterMedFacts.com

Amaya-Garrido A, et al. Calprotectin is a contributor to and potential therapeutic target for vascular calcification in chronic kidney disease. Sci Transl Med. 2023 Sep 6;15(712):eabn5939. doi: 10.1126/scitranslmed.abn5939. Epub 2023 Sep 6. PMID: 37672568.

🎧 Dr RR Baliga's Internal Medicine 'Got Knowledge Doc' Podcasts for Physicians: MUST KNOW FACTs about Hyperkalemia.

Not Medical Advice or Opinion.