While some may liken their morning coffee ritual to a religious experience, the reality is the act of brewing that cup of coffee is often centered around personal gratification rather than spiritual connection. Despite our hopes and expectations of heightened focus and familiarity with the taste and aroma, caffeine's effects may not necessarily transcend into the spiritual realm. So what, if anything, is inherently spiritual about our relationship with caffeine? In the last conversation on caffeine, Kirtly Jones, MD, reflects on the spiritual dimensions of our caffeine habits and the broader cultural and religious contexts surrounding its consumption.