This episode is a recording of the retina-focused EyeNovation webinar episode which was a collaboration between Canadian Ophthalmological Society and the Canadian Retina Society. Dr. Chakravarthy will provide a background to the double layer sign, its definition and how it is detected. Data to support the presentation will be from the EDNA trial . This study possesses an imaging dataset that was captured longitudinally in over 500 high risk eyes and obtained robust rates of progression to neovascularization as well as time to the event. The presence of the DLS and or other features of intermediate AMD were assessed at baseline and included measurements of length of separation of the RPE from its basement membrane, height of separation and the number of B scans involved. Rates of progression in eyes without and with DLS were computed and models built to assess risk of progression to neovascularization. In addition the DLS and SIRE signs were compared for their contributions to risk of progression. The findings from these analyses and their clinical significance will be discussed .

Make sure to register for the Canadian Retina Society (CRS) annual meeting which will take place in Vancouver, BC from April 25-27, 2025. Go to https://www.crsscr.ca to register.