In this episode of The Retina Channel Podcast, Dr. Jennifer Sun joins Dr. Keyvan Koushan to discuss the Phase 2 results of DRCR Retina Network Protocol AN evaluating tonabersat for diabetic macular edema. Dr. Sun reviews the rationale behind targeting connexin-43–mediated inflammatory pathways in DME, the key efficacy and safety findings from the study, and the potential implications of this novel oral therapy for future diabetic retinal disease management. The conversation also explores broader trends in DRCR clinical research and emerging treatment paradigms in diabetic eye disease.