EMJ Podcast: Insights For Healthcare Professionals

In the second episode of our Rare Lung Diseases podcast mini-series, host Saranya Ravindran delves into the complexities of pulmonary arterial hypertension (PAH) with Neal Chaisson, Assistant Professor of Medicine at the Cleveland Clinic. Chaisson shares insights into why PAH remains under-recognised, the nuances of detection and diagnosis, and what the latest advancements mean for patients and clinicians. The discussion covers everything from early warning signs to future directions in PAH management and research.

In the first episode of our Rare Lung Diseases podcast series, host Saranya Ravindran speaks with James Stoller, Chief of Education and Pulmonary Physician at Cleveland Clinic, about Alpha-1 antitrypsin deficiency, a rare genetic condition that is frequently underdiagnosed. The discussion explores the complexities of Alpha 1, including current challenges in detection, advances in diagnosis and management, and what the future may hold for improving care.

Timestamps:

1:20 - Current barriers to timely diagnosis

4:35 - How close are we to identifying all patients with Alpha 1?

5:20 - Role of consumer genomics in alpha detection

6:20 – Targeted testing amongst COPD patients

In the first episode of our Rare Lung Diseases podcast series, host Saranya Ravindran speaks with James Stoller, Chief of Education and Pulmonary Physician at Cleveland Clinic, about Alpha-1 antitrypsin deficiency, a rare genetic condition that is frequently underdiagnosed. The discussion explores the complexities of Alpha 1, including current challenges in detection, advances in diagnosis and management, and what the future may hold for improving care.

Timestamps:

01:00 - Management of Alpha 1

03:30 - Augmentation therapy

05:50 - The discussion of neonatal screening for Alpha 1

08:00 - Evolving landscape

09:40 - Patients' challenges with Alpha 1

11:20 - Closing comments on Alpha 1

In this episode, host Jonathan Sackier is joined by Steven Okoli, Honorary Senior Clinical Lecturer at Imperial College London. From leading the UK's first adult stem cell transplant trial for sickle cell disease to driving innovation in AI-guided transfusion strategies, Okoli shares how clinical research, patient advocacy, and equity-driven care are reshaping the landscape of haemoglobinopathies in the UK and beyond.

Timestamps

00:00: Introduction

01:58: Quickfire round

09:09: Pioneering adult stem cell transplant in sickle cell

11:41: Combining AI and genetics for blood transfusion

13:58: Systemic disparities in sickle cell

20:58: Education and advocacy

23:30: Non-cancerous blood disorders

25:18: What's next in sickle cell?

27:27: Okoli's three wishes for healthcare

In the first episode of our Rare Lung Diseases podcast series, host Saranya Ravindran speaks with James Stoller, Chief of Education and Pulmonary Physician at Cleveland Clinic, about Alpha-1 antitrypsin deficiency, a rare genetic condition that is frequently underdiagnosed. The discussion explores the complexities of Alpha 1, including current challenges in detection, advances in diagnosis and management, and what the future may hold for improving care.

In the first episode of our Rare Lung Diseases podcast series, host Saranya Ravindran speaks with James Stoller, Chief of Education and Pulmonary Physician at Cleveland Clinic, about Alpha-1 antitrypsin deficiency, a rare genetic condition that is frequently underdiagnosed. The discussion explores the complexities of Alpha 1, including current challenges in detection, advances in diagnosis and management, and what the future may hold for improving care.

Timestamps

00:56 – What is Alpha-1 antitrypsin deficiency?

01:45 – Mechanism of this genetic disorder

03:12 – What makes Alpha 1 so hard to spot?

04:30 – Genetic complexities of Alpha 1

06:00 – Risk factors

In this episode of Onc Now, host Jonathan Sackier is joined by Jean Abraham, Professor of Precision Breast Cancer Medicine at the University of Cambridge, to delve into the future of integrated cancer medicine, the evolving role of clinical trials, and how precision oncology is redefining outcomes for patients with breast cancer across the UK.

Timestamps

00:00 – Introduction

01:28 – Quickfire round

09:50 – Cambridge institutes for precision medicine

12:53 – Predictive/prognostic tools in breast cancer

15:33 – The future of breast cancer clinical trials

18:34 – Integrating genomic data

22:31 – Addressing cost barriers

24:22 – How AI is transforming breast cancer care

28:08 – Why oncology?

30:04 – A message to non-oncologists

31:54 – Abraham's three wishes for healthcare

In this episode, Jonathan Sackier welcomes Claudio Cerchione, haematologist and researcher at the Hematology Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy. From his early interest in plasma cell disorders, Cerchione shares key insights into the evolution of multiple myeloma (MM) research, the rising role of minimal residual disease (MRD), and promising developments in monoclonal antibodies and CAR-T therapy. He also reflects on standout moments from recent European Hematology Association (EHA) Congress and American Society of Clinical Oncology (ASCO) Annual Meeting, and shares his hopes for the future of haematology.

Timestamps:

• 2:14: Memorable career experiences for Claudio

• 4:20 Biggest breakthrough in MM

• 5:10 Interest in plasma cell disorders

• 6:30 A surprising fact about multiple myeloma

• 7:40 Claudio's top choice for a dinner party guest

• 10:30 The importance of MRD in haematology

• 13:00 Monoclonal antibodies and CAR-T therapies

• 19:00 Current challenges

• 22:22 Claudio's key EHA and ASCO takeaways

• 28:30 Claudio's three magic wishes

In this three-part series, Jonathan Sackier sits down with Professor Zoë Paskins to explore the complexities and advancements in rheumatology and bone health. From her personal journey into the field to innovations in managing osteoporosis and arthritis, Zoë offers compelling insights into the current landscape and future of musculoskeletal care.

Timestamps:

0:25 - What's new in osteoporosis management?

5:05 - Key challenges in addressing gaps in care

In this three-part series, Jonathan Sackier sits down with Professor Zoë Paskins to explore the complexities and advancements in rheumatology and bone health. From her personal journey into the field, to innovations in managing osteoporosis and arthritis, Zoë offers compelling insights into the current landscape and future of musculoskeletal care.

Timestamps:

00:00 - Introduction

03:45 - Zoë's start in rheumatology and what keeps her passionate

06:27 - Shared decision-making in rheumatology

12:30 - How should we be screening for osteoporosis?