EMJ Podcast: Insights For Healthcare Professionals

This podcast series was sponsored by Theramex UK who had no input in the content which was developed by EMJ.

The speakers were selected by Theramex and received honorarium. The views and opinions expressed in this podcast are those of the individual speakers and do not necessarily reflect those of Theramex or EMJ. Please refer to local marketing authorisation and prescribing practices for guidance.

Long-term Benefits of Use of MHT/HRT on the Heart, Bones, and Brain - Episode 1 - Heart expert Yassir Javaid joins Hannah Moir to discuss the role of MHT in cardiovascular health.

In this podcast series, we focus on women's health and the impact of menopause. Our experts explore the role and long-term impact of menopausal hormone therapy (MHT), otherwise referred to as hormone replacement therapy (HRT), on our heart, bones, and brain.

In this episode, Jonathan Sackier welcomes Andrew Blauvelt, a distinguished dermatologist and leading expert in immunodermatology. They discuss groundbreaking advancements in psoriasis treatment, including the role of high-dose biologics in achieving deep remission and how IL-23 inhibition is transforming long-term disease management.

Timestamps:

• (00:00) – Introduction
• (02:25) – A recent knockout study
• (17:22) – The wider applications of biologic treatments
• (19:40) – Deep remission in psoriasis
• (27:20) – The next frontier in psoriasis research
• (32:36) – Barriers to research breakthroughs
• (36:11) – What's on the horizon for dermatology research?
• (41:37) – Andrew's three wishes for healthcare

This week, Jonathan is joined by Xavier Leleu, world-renowned expert in multiple myeloma, Waldenström's macroglobulinemia, and amyloidosis. The pair discuss groundbreaking advances in clinical trials and the future of myeloma immunotherapy.

Timestamps:

(00:00)-Introduction

(00:59)-Clinical trial breakthroughs in transplant-ineligible myeloma

(03:38)-Minimal residual disease: a key endpoint

(05:21)-Rethinking therapeutic strategies in myeloma

(10:58)-Challenges in late-line myeloma therapies

(13:54)-T-cell-engaging bispecific antibodies

(17:41)-Waldenström's macroglobulinemia and amyloidosis

(21:50)-What's next in multiple myeloma treatment?

(24:43)-Xavier's three wishes for healthcare

In this episode, Jonathan Sackier welcomes Andrew Southerland, a distinguished neurologist and academic leader in the field of vascular neurology. They explore how machine learning is revolutionising prehospital stroke diagnosis, and how innovative strategies like telemedicine can reduce disparities in stroke care.

Timestamps:

• (00:00) – Introduction
• (03:00) – Neurologic lessons from the wild turkey
• (05:10) – Linking COVID-19 and stroke
• (10:28) – How can AI revolutionise prehospital stroke diagnosis?
• (18:39) – Stroke management in underserved populations
• (23:38) – Google Glass in medical education
• (29:06) – What is the i-corps programme?
• (33:24) – Wearable devices as diagnostic tools
• (37:08) – Andrew's three wishes for healthcare

In this episode of the Onc Now Podcast, host Jonathan Sackier is joined by Heather McArthur, Associate Professor in the Department of Medicine at University of Texas, UT Southwestern Medical Center, USA. They discuss recent advancements in breast cancer immunotherapy and the future of personalised care.

Timestamps:

00:00 - Introduction

01:20 - Transformative breakthroughs in immunotherapy

03:51 - Communicating new research to the public

05:48 - Racial disparities in cancer screenings

07:22 - Unmet needs in treating triple-negative breast cancer

11:48 - Genomic profiling and molecular pathways

13:30 - Barriers to personalised treatment plans

15:09 - Designing and conducting large-scale, international trials

19:16 - Optoacoustic imaging in cancer

22:52 - The 'first' cell and the heterogeneity of breast tumours

25:21 – Heather's three wishes for healthcare

This week, Jonathan sits down with Jacqueline French to explore groundbreaking innovations in epilepsy research, the challenges of misdiagnosis, and the transformative impact of advancements in clinical trial methodologies. French also shares insights into global epilepsy care challenges, and her vision for the future of neurological health.

Timestamps:

• (00:00) - Introduction

• (01:34) - Career beginnings

• (07:38) - The Epilepsy Study Consortium

• (14:48) - Ethical considerations in clinical trials

• (17:13) - New strategies for designing trials

• (25:25) - The evolving landscape of anti-seizure drugs

• (27:45) - Innovative treatments

• (32:30) - Cases of misdiagnosis

• (35:19) - The five S's to identify epilepsy

• (39:12) - Educating and tackling stigma

• (44:03) - French's three wishes for healthcare

This week, Jonathan is joined by Eytan Stein, Chief of the Leukaemia Service and an Attending Physician at Memorial Sloan Kettering Cancer Center, New York, USA.

Timestamps:

(00:00)-Introduction

(01:05)-The current landscape of treatments

(02:26)-The promise and peril of differentiation therapy

(05:55)-Highlighting the most impactful clinical trials

(08:38)-Epigenetics and the future of targeted therapies

(10:40)-The BEAT AML master clinical trial

(12:57)-The latest research into IDH inhibitors

(16:10)-Therapies for splicing factor mutations

(19:29)-Reducing patient fear with education

(22:46)-Stein's three wishes for healthcare

In this second part of the podcast, Jonathan welcomes back Douglas Drossman, pioneer in disorders of gut-brain interaction. He discusses key takeaways for clinicians from his 'Gut Feelings' book series and explores the link between trauma, drug addiction, and functional gastrointestinal disorders.

Timestamps:

• (00:00) – Introduction

• (0:54) – Takeaways from the 'Gut Feelings' series

• (08:40) – Trauma and IBS: a complex link

• (11:31) – Opioid-induced hyperalgesia

• (14:18) – New horizons in the field of gut-brain interactions

• (17:18) – Career highs and lows

• (20:33) – AI in medical education

• (24:01) – Drossman's three wishes for healthcare

In this episode of the Onc Now Podcast, host Jonathan Sackier is joined by Donal Brennan, a leader in gynaecological oncology and Principal Investigator at Systems Biology Ireland. Together, they discuss advances in ovarian cancer surgery, including cytoreductive techniques and hyperthermic intraperitoneal chemotherapy (HIPEC), as well as the impact of obesity on cancer development and treatment strategies.

Brennan also shares insights on platinum resistance in ovarian cancer, the FeMMe trial exploring weight loss as a treatment for endometrial cancer, and his innovative approaches in surgical oncology.

This episode is essential listening for anyone interested in the future of cancer treatment, innovation in surgery, and patient-centred care.

Timestamps:

(00:00) - Introduction

(01:51) - Music debates in the surgical theatre

(03:42) - Evolution of surgical techniques in ovarian cancer

(06:32) - The importance of early diagnosis

(08:18) - State-of-the-art on HIPEC in gynaecological oncology

(11:36) - Obesity's impact on cancer diagnosis and treatment

(19:06) - The FeMMe trial: weight loss as a treatment for endometrial cancer

(21:47) - Platinum resistance in ovarian cancer and future therapies

(28:14) - Innovation in gynaecological surgery and medical technology

(29:53) - The COMFORT trial: mental health and cancer treatment

(33:24) - Biggest challenges and opportunities in gynaecological oncology research

(37:42) - Three wishes for the future of cancer treatment

In this episode of the EMJ Podcast, host Jonathan Sackier welcomes William Lombardi, one of the leading innovators in chronic total occlusion (CTO) percutaneous coronary intervention (PCI). They explore his groundbreaking work in CTO technology, the development of the hybrid algorithm, and lessons interventional cardiologists can learn from aviation safety.

Lombardi also shares insights into reducing practitioner risk, the mental resilience required in high-stakes medicine, and what drives his passion for innovation.

This is a must-listen for anyone interested in advancing cardiology, operator safety, and medical innovation.

Timestamps:

(00:00) - Introduction (01:50) - The story behind 'Lioness' and family time on the water (06:15) - Learning from aviation: improving safety in PCI (11:14) - Changing the mindset in interventional cardiology (20:10) - The hybrid algorithm and its impact on CTO PCI (27:35) - From idea to market: innovating over 20 CTO technologies (35:14) - Reducing risk for interventional cardiologists (38:37) - The importance of mental health in performance (44:00) - Three wishes for the future of healthcare