EMJ Podcast: Insights For Healthcare Professionals

In the final episode, Naveed Sattar explores the future of cardiometabolic medicine, from novel therapies and AI-driven risk prediction to integrated care pathways and the next generation of preventative strategies for diabetes and cardiovascular disease.

Timestamps:

0:56 – Novel interventions

2:10 – Digital health and AI

4:17 – Integrated care

5:26 – Future directions

7:11 – Naveed's prediction

In Part 2, Naveed Sattar discusses obesity, ectopic fat, and cardiovascular risk. Learn how imaging and biomarkers are improving risk identification, why metabolic dysfunction matters beyond BMI, and how GLP-1 therapies are reshaping obesity and cardiovascular care.

Timestamps:

0:56 – Ectopic fat

11:44 – Metabolic dysfunction

13:42 – GLP-1 receptor agonists

19:05 – Mechanistic insights

21:31 – Societal issues

Naveed Sattar joins host Catherine Glass to explore the complex relationship between diabetes and cardiovascular disease. From hyperglycaemia and inflammation to diabetes onset age and risk prediction, this episode examines the mechanisms and evidence shaping cardiometabolic care today.

Timestamps:

0:55 – Diabetes to heart disease

4:35 – Age of onset

6:21 – Statins

09:01 – Epidemiological insights

12:29 – Improving risk prediction

In this rapid-fire episode, Naveed Sattar answers key questions on diabetes, cardiovascular disease, obesity, prevention, and emerging therapies. From precision medicine and GLP-1 receptor agonists to lifestyle interventions and research advice, this concise episode provides expert insight into the future of cardiometabolic medicine.

In the final episode, the focus turns to prevention. Rachel Buckley examines whether Alzheimer's strategies should be sex-specific, the timing of interventions, and how lifestyle factors like physical activity contribute to brain resilience. The discussion also highlights gaps in research and the need for better integration of women's health data.

Timestamps:

00:00:45:13 – Sex-disaggregated data for prevention

00:03:26:15 – Sex-specific timing for therapeutics

00:05:07:20 – Non-pharmacological interventions

00:07:58:02 – Gaps in reproductive data

This episode explores how reproductive ageing and biological sex influence Alzheimer's disease risk. Rachel Buckley discusses menopause, hormonal changes, genetic factors such as the X chromosome, and emerging evidence showing differences in tau accumulation between women and men.

Timestamps:

00:00:55:03 – Menopause and Alzheimer's disease

00:04:51:11 – X chromosome in Alzheimer's disease

00:08:29:01 – Tau accumulation in women

00:10:43:09 – Hormone replacement therapy

00:14:22:24 – The sweet spot with hormone therapy

In this episode of Onc Now, Paolo Bironzo joins us to discuss the evolving landscape of thoracic oncology and the innovations transforming lung cancer care. From targeted therapies and immunotherapy selection to advances in mesothelioma treatment and molecular profiling, Bironzo shares insights into the challenges clinicians face today and the future of precision medicine. He also reflects on the importance of treatment de-escalation, the complexities of clinical trials, and offers advice for the next generation of oncologists.

Timestamps:

00:00 – Introduction

00:51 – Inspiration Behind Thoracic Oncology

03:17 – Current Challenges in Lung Cancer

04:50 – Impact of Targeted Therapies

07:14 – Selecting Patients for Immunotherapy

08:04 – Advances in Mesothelioma Treatment

14:52 – Molecular Profiling in Thoracic Cancer

19:52 – Challenges in Lung Cancer Trials

22:05 – Predicting Immunotherapy Response Challenges

24:23 – Future of Precision Medicine

26:05 – Advice for Early-Career Oncologists

28:40 – Three Wishes for Cancer Therapy

In this first deep dive, Rachel Buckley joins host Catherine Glass to explore how Alzheimer's disease risk can be detected before symptoms appear. From blood-based biomarkers like p-tau217, to AI-driven models of cognitive resilience, the episode examines how risk, progression, and protection can be better understood and predicted over time.

Timestamps:

00:00:57:11 – Phosphorylated tau and amyloid-PET

00:08:15:05 – Biomarkers, risk, and progression

00:11:18:04 – Brain resistance and cognitive resilience

00:15:23:23 – AI biases

In this rapid-fire episode, Rachel Buckley answers key questions on Alzheimer's disease, covering sex differences in risk, early predictors of progression, brain resilience, and the most actionable prevention strategies. A concise overview of the evolving science behind personalised Alzheimer's care.

In the final episode, host Saranya and Helen Brough examine the key gaps in allergy care across prevention, diagnosis, and long-term management, and how these challenges impact families in practice. It explores barriers to early peanut introduction, highlights inequalities in allergy care and the populations most affected, and looks at how digital tools, education, and outreach could help improve access to evidence-based care.

Timestamps:

00:43 – Gaps in allergy care

04:07 – Early peanut introduction

06:39 - Disparities in diagnosis

08:12 – Improve access to care