Endo in a Bite

This episode reviews the Endocrine Society’s 2025 guideline updates on managing primary aldosteronism after initial screening.

• When suppression testing is indicated or unnecessary

• Cortisol cosecretion in adrenal adenomas and surgical planning

• Role of adrenal vein sampling (AVS) in determining laterality, with rare exceptions

• Treatment strategies for unilateral vs bilateral disease

• MRA therapy, titration approach, and importance of renin response

In this episode, we review the ATA 2025 thyroid cancer guideline updates on tumors of uncertain malignant potential and when germline genetic testing is appropriate.

Topics include:

• NIFTP and related tumors with strict pathologic criteria and low malignant risk

• Management pearls and pitfalls of overtreatment

• Indications for germline testing (PTEN, DICER1, APC, Carney complex, Werner syndrome)

• Why non-syndromic familial thyroid cancer does not justify routine testing

• Screening approaches for relatives and risks of overdiagnosis

• Interpreting tumor sequencing results and confirming germline variants

This episode reviews medications and hormonal therapies that can falsely raise the Aldosterone-to-Renin Ratio (ARR), creating false-positive results in primary aldosteronism screening.

• Covers centrally acting alpha-2 agonists, beta blockers, NSAIDs, and combined estrogen-progestin therapy.

• Explains mechanisms for PAC and renin changes, highlighting discordance between PRA vs DRC assays.

• Reviews practical withdrawal timelines (minimal vs full) to reduce confounding before ARR testing.

This episode reviews my key notes on medications and factors that can falsely lower the Aldosterone-to-Renin Ratio (ARR), leading to missed cases of primary aldosteronism.

• Organized into strong, intermediate, and weak confounders for quick clinical reference.

• Includes the most important non-medication factor to correct before testing: hypokalemia.

• Four-part series highlighting my personal notes and key clinical insights from the newly released 2025 Endocrine Society guidelines on Primary Aldosteronism

• Each episode translates complex recommendations into practical, board-focused guidance you can apply immediately

• Episode 1 features two ready-to-use tools:

  • Clear patient instructions to follow before lab testing

  • Detailed instruction sheet for lab technicians

This high-yield episode breaks down exactly why Lp(a) is gaining attention as a critical cardiovascular risk factor. It's genetically determined, stable for life, and not modified by lifestyle. Dr. Beg reviews who needs testing, when to test, and how Lp(a) contributes to atherosclerosis, inflammation, and calcific aortic valve disease.

We’ll also dive into current and emerging treatment options including PCSK9 inhibitors and promising RNA-based therapies like Pelacarsen and Olpasiran and clarify when Lp(a) testing is essential for your board prep, LKA, or everyday patient care.

Perfect for:
• Internal medicine & endocrine board review
• LKA prep
• Clinicians managing lipid disorders or ASCVD risk

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Ready to master MASLD and MASH for your boards and daily practice? This episode cuts straight to the chase, delivering crucial, latest pearls on this evolving liver disease. We cover everything from new terminology and risk factors (including PCOS), to statin use, screening essentials (FIB-4, FibroScan), and the latest treatments including FDA-approved Resmetirom. Get sharp on diagnosis, management, and referral. Perfect for board prep, LKA, and refining your patient care. Want episode notes? Subscribe at ezendoprep.com.

Are you staying sharp for boards or brushing up on practical diabetes care? This quick episode covers the most up to date vaccine guidelines for patients with diabetes…straight from board review content. Learn how to apply CDC recommendations on Hepatitis B, Pneumococcal, Influenza, RSV, COVID-19, and Shingles. Discover smart memory tricks and practical clinical decision points to keep you board ready and real world sharp.

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