For over a century, the treatments and technologies used to treat diabetes have evolved. New tools are now available to aid in diabetes management and to help patients further manage and better control their glucose levels.

1,2 Through their recently announced collaboration, Dexcom and Lilly are at the forefront of enhancing diabetes care.

3 In this episode Dr. Chad Worz and guest speakers Deirdre Ibsen and Dr. Thomas Blevins discuss these important technological and therapeutic achievements over time, as well as 2 products available from Dexcom and Lilly and how they may benefit patients with diabetes.

References: 

Dexcom G6 Pro User Guide. https://dexcompdf.s3-us-west-2.amazonaws.com/Dexcom-G6-Pro-User-Guide.pdf. Accessed October 12, 2020.

Lyumjev [Prescribing Information]. Indianapolis, IN: Lilly USA, LLC.

Eli Lilly and Company. Lilly and Dexcom team up on new program to help improve diabetes management. https://provider.dexcom.com/products/dexcom-g6-pro/training-resources. Accessed October 12, 2020.

Centers for Disease Control. National Diabetes Statistics Report 2020 Estimates of Diabetes and Its Burden in the United States. https://www.cdc.gov/diabetes/pdfs/data/statistics/national-diabetes-statistics-report.pdf. Accessed October 1, 2020.

American Diabetes Association. Diabetes and Quality of Life. http://journal.diabetes.org/diabetesspectrum/00v13n1/pg48.htm. Accessed October 1, 2020.

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American Diabetes Association. 7. Diabetes Technology: Standards of Medical Care in Diabetes-2020. Diabetes Care. 2020;43(suppl 1):S77-S88.

Hirsch IB. History of Glucose Monitoring. https://professional.diabetes.org/sites/professional.diabetes.org/files/media/db201811.pdf. Accessed October 1, 2020.

White JR. A brief history of the development of diabetes medications. Diabetes Spectr. 2014;27(2):82-86.

Science History Institute. Frederick Banting, Charles Best, James Collip, and John Macleod. https://www.sciencehistory.org/historical-profile/frederick-banting-charles-best-james-collip-and-john-macleod. Accessed October 1, 2020.

American Diabetes Association. Timeline. https://www.diabetes.org/resources/timeline. Accessed October 9, 2020.

Humalog [Prescribing Information]. Indianapolis, IN: Lilly USA, LLC.

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American Association of Diabetes Educators. Insulin Injection Know-How. https://www.diabeteseducator.org/docs/default-source/legacy-docs/_resources/pdf/general/Insulin_Injection_How_To_AADE.pdf. Accessed October 1, 2020.

Hyllested-Winge J, Jensen KH, Rex J. A review of 25 years’ experience with the NovoPen® family of insulin pens in the management of diabetes mellitus. Clin Drug Investig. 2010;30(10):643-674.

Eli Lilly and Company. Lilly Launches KwikPen(TM) for Humalog(R) and Humalog Mixtures [press release]. https://investor.lilly.com/news-releases/news-release-details/lilly-launches-kwikpentm-humalogr-and-humalog-mixtures. Accessed October 12, 2020.

American Diabetes Association. 6. Glycemic Targets: Standards of Medical Care in Diabetes-2020. Diabetes Care. 2020;43(suppl 1):S66-S76.

Garber AJ, Handelsman Y, Grunberger G, et al. Consensus statement by the American Association of Clinical Endocrinologists and American College of Endocrinology on the comprehensive type 2 diabetes management algorithm - 2020 executive summary. Endocr Pract. 2020;26(1):107-139.

Fonseca VA, Grunberger G, Anhalt H, et al. Continuous glucose monitoring: a consensus conference of the American Association of Clinical Endocrinologists and American College of Endocrinology. Endocr Pract. 2016;22(8):1008-1021.

Battelino T, Danne T, Bergenstal RM, et al. Clinical targets for continuous glucose monitoring data interpretation: recommendations from the international consensus on time in range. Diabetes Care. 2019;42(8):1593-1603.

Dexcom G6 Pro Unblinded Patient Guide. https://dexcompdf.s3-us-west-2.amazonaws.com/Dexcom-G6-Pro-Unblinded-Patient-Guide.pdf. Accessed October 12, 2020.

Dexcom Announces FDA Clearance of New Dexcom G6 Pro CGM. https://provider.dexcom.com/industry-news/fda-authorizes-dexcom-g6-pro. Accessed October 2, 2020.

Beck RW, Riddlesworth T, Ruedy K, et al. Effect of continuous glucose monitoring on glycemic control in adults with type 1 diabetes using insulin injections: the DIAMOND randomized clinical trial. 2017;317(4):371-378.

Beck RW, Riddlesworth TD, Ruedy K, et al. Continuous glucose monitoring versus usual care in patients with type 2 diabetes receiving multiple daily insulin injections: a randomized trial. Ann Intern Med. 2017;167(6):365-374.

Polonsky WH, Hessler D, Ruedy KJ, Beck RW. The impact of continuous glucose monitoring on markers of quality of life in adults with type 1 diabetes: further findings from the DIAMOND randomized clinical trial. Diabetes Care. 2017;40(6):736-741.

Pratley RE, Kanapka LG, Rickels MR, et al. Effect of continuous glucose monitoring on hypoglycemia in older adults with type 1 diabetes: a randomized clinical trial. 2020;323(23):2397-2406.

Ruedy KJ, Parkin CG, Riddlesworth TD, Graham C. Continuous glucose monitoring in older adults with type 1 and type 2 diabetes using multiple daily injections of insulin: results from the DIAMOND trial. J Diabetes Sci Technol. 2017;11(6):1138-1146.

Lind M, Polonsky W, Hirsch IB, et al. Continuous glucose monitoring vs conventional therapy for glycemic control in adults with type 1 diabetes treated with multiple daily insulin injections: the GOLD randomized clinical trial. 2017;317(4):379-387.

Frequently Asked Questions. https://provider.dexcom.com/products/dexcom-g6-pro/faqs. Accessed October 15, 2020.

Dexcom Products: Dexcom G6 Pro. https://provider.dexcom.com/products/professional-cgm. Accessed October 15, 2020.

How to Customize Alarm and Alerts. https://www.dexcom.com/faqs/how-to-customize-alarm-and-alerts. Accessed October 15, 2020.

Trend Arrows and Treatment Decisions. https://s3-us-west-2.amazonaws.com/dexcompdf/HCP_Website/LBL015804+G6+Trend+Arrows+and+Treatment+Decisions.pdf. Accessed October 15, 2020.

Why CGM? https://provider.dexcom.com/why-cgm. Accessed October 12, 2020.

Pharmacy Coverage. https://provider.dexcom.com/pharmacy-coverage. Accessed October 12, 2020.

Is There Reimbursement for Using Dexcom G6 Pro? https://provider.dexcom.com/faqs/there-reimbursement-using-dexcom-g6-pro. Accessed October 12, 2020.

Hypoglycemia Unawareness. https://provider.dexcom.com/education-research/clinical-evidence/clinical-studies/real-time-continuous-glucose-monitoring-cgm. Accessed October 15, 2020.

Garg SK, Wernicke-Panten K, Wardecki M, et al. Safety, immunogenicity, and glycemic control of insulin aspart biosimilar SAR341402 versus originator insulin aspart in people with diabetes also using insulin glargine: 12-month results from the GEMELLI 1 trial. Diabetes Technol Ther. 2020;22(7):516-526.

Dexcom G6 Pro Blinded Patient Guide. https://dexcompdf.s3-us-west-2.amazonaws.com/HCP_Website/Dexcom+G6+Pro+Resources/LBL017177+Rev+004+Artwork%2C+Dexcom+G6+Pro+Blinded+Patient+Guide+US_r5_WEB.pdf. Accessed November 24, 2020.

Dexcom CLARITY Diabetes Management Software. https://www.dexcom.com/clarity. Accessed May 15, 2020.

Blevins T, Zhang Q, Frias JP, Jinnouchi H, Chang AM. Randomized double-blind clinical trial comparing ultra rapid lispro with lispro in a basal-bolus regimen in patients with type 2 diabetes: PRONTO-T2D. Diabetes Care. Published online July 2, 2020. doi: 10.2337/dc19-2550.

Klaff L, Cao D, Dellva MA, et al. Ultra rapid lispro improves postprandial glucose control compared with lispro in patients with type 1 diabetes: results from the 26-week PRONTO-T1D study. Diabetes Obes Metab. 2020;22(10):1799-1807.

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