Karen “Duff” Duffy, the former MTV VJ, actress, and bestselling author of Model Patient: My Life as an Incurable Wise-Ass, Backbone: Living with Chronic Pain Without Turning into One, and Wise Up: Irreverent Enlightenment from a Mother Who’s Been Through It. 

Duff opens up about her unforgettable years in the MTV spotlight, her Hollywood adventures (including Dumb and Dumber), and how her diagnosis with chronic pain changed the way she views purpose, humor, and happiness. She shares her philosophy on resilience, creativity, and joy — proving that wisdom doesn’t have to come without wit. 

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