October 16, 2023

Ep. 156: dooming ourselves with medicine

2 hours 55 minutes

Our favorite boffin, Eileen Marks-Nelson, is here to chat with us about a listener science concern that turned out to be WAY more troubling than we even anticipated: Antimicrobial resistance. Medicine has extended our lives, but has our use of it shortened them?

Highlights:

[0:00] Marko tells CoRri and Eileen about Miriam Rodriguez, the middle aged Mexican woman who took on the cartels solo to get justice for her daughter
[15:09] Mark’s American child accent leads us to a brief discussion of Sylvester Stallone and the Rocky films, and then. we remember to introduce our pal Eileen Marks-Nelson
[22:04] What we watched! (Fall of the House of Usher, The Reckoning, , Friday the 13th: A New Beginning, Totally Killer, Vampire in Brooklyn, 10 Cloverfield Lane, Ernest Scared Stupid, Deadstream, Train To Busan, Dead Alive, The Host, Carrie, A Girl Walks Home Alone At Night, Insidious, VHS85, The Creator)
[69:10] Eileen tells us about antimicrobial resistance, and why we’re sleeping on one of the biggest threats to human existence

Stuff we referenced:

History of medicine – 20th Century, Advancements, Innovations | Britannica

Bacteria | Basic Biology

Ancient brew masters tapped antibiotic secrets | ScienceDaily

Tetracycline-Labeled Human Bone from Ancient Sudanese Nubia (A.D. 350) | Science

Moulds in Ancient and more recent medicine

Antiviral Resistance: Antivirals, Antimicrobial Resistance, HIV (clevelandclinic.org)

The Challenge of Antibiotic-Resistant Staphylococcus: Lessons from Hospital Nurseries in the mid-20th Century

ALEXANDER FLEMING Penicillin Nobel Lecture, December 11, 1945

Antibiotics: Conventional Therapy and Natural Compounds with Antibacterial Activity—A Pharmaco-Toxicological Screening

Unearthing the story of the first antifungal drugs

Penicillin | Discovery, History, Uses, Types, Side Effects, & Facts | Britannica

Methicillin-resistant Staphylococcus aureus emerged long before the introduction of methicillin into clinical practice

Changes in Intestinal Flora of Farm Personnel after Introduction of a Tetracycline-Supplemented Feed on a Farm | NEJM

Drug Companies Accept FDA Plan To Phase Out Some Animal Antibiotic Uses : The Salt : NPR

E-I-E-I-Oh no: Decades of antibiotics in farm animals lead to deadly superbugs | Grist

Study: Farmed Fish Could Be Another Source of Antibiotic Resistance | Food Safety News

Recent Advances in the Discovery of Novel Antiprotozoal Agents

Drug Development to Protozoan Diseases

WHO’s first global report on antibiotic resistance reveals serious, worldwide threat to public health

Humans Can No Longer Ignore the Threat of Fungi

Antimicrobial resistance: a global threat | UNEP – UN Environment Programme

AMR2023_summary_EN.pdf (unep.org)

When the drugs don’t work: can we do anything about antimicrobial resistance? | Global development | The Guardian

Malaria-causing parasites resistant to both treatment and detection have emerged in Ethiopia

Antibiotics: Combatting Tolerance To Stop Resistance

COVID-19 Reverses Progress in Fight Against Antimicrobial Resistance in U.S.

Paxlovid-Resistant Covid ‘Discovered’ Should We Worry?

Paxlovid Resistance: Is It Just a Matter of Time Now?

Disinfectant resistance in bacteria: Mechanisms, spread, and resolution strategies – ScienceDirect

Resisting disinfectants | Communications Medicine (nature.com)

U.S. Antibiotic Awareness Week Toolkit 2022 (cdc.gov)

A Superbug Stalked My Daughter and Stole Her Life. Phage Therapy Could Have Saved Her | Blogs | CDC

An insight into the antifungal pipeline: selected new molecules and beyond

Using viruses to treat antibiotic-resistant bacterial infections

Nanoantibiotics: Functions and Properties at the Nanoscale to Combat Antibiotic ResistanceMicrobes that cause cavities can form superorganisms able to ‘crawl’ and spread on teeth

...more

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