The Genetics Podcast

EP 196: A new vision for sequencing: In-sample multiomics and precision medicine with Molly He


Listen Later

This week on The Genetics Podcast, Patrick is joined by Molly He, CEO and co-founder of Element Biosciences. They discuss the current landscape of sequencing technologies, Element’s innovative sequencing platform, and the potential of using in-sample multiomic profiling across different stages of drug discovery. 

Show Notes: 

0:00 Intro to The Genetics Podcast

00:59 Welcome to Molly

01:42 Persistent barriers in precision medicine

04:54 Limitations of multiomics technologies and the unique advantage of Element’s approach

07:33 How Element started by inventing an ambitious sequencing instrument

11:33 Overview of the chemistry behind Element’s sequencing technology

14:41 Sequencing workflow of Element’s technology and technical advantages

18:24 Sequencing inside cells and drug discovery insights from a study on tyrosine kinase inhibitor (TKI) resistance pathways

25:57 Sequencing for CRISPR perturbation and direct genotype–phenotype linkage in the same cell

27:33 Whole-transcriptome in situ sequencing and applications in patient samples

29:19 Simplifying single-cell transcriptomics with direct in-sample sequencing

30:31 Applying the single-cell spatial technology to different steps of the drug discovery process

36:43 Competition in the sequencing industry and recent news about Illumina filing a patent infringement case against Element

38:43 Lessons from building Element over eight years

40:32 Insight into maintaining a cohesive culture as Element has multiplied in size and across countries

42:06 The importance of input data quality for AI applications and excitement about the possibility of predicting biology

45:40 Closing remarks

Find out more

  • Element Biosciences (https://www.elementbiosciences.com/)

  • Pre-print (https://www.biorxiv.org/content/10.1101/2025.05.06.652479v1)

Please consider rating and reviewing us on your chosen podcast listening platform! 

https://drive.google.com/file/d/1Bp2_wVNSzntTs_zuoizU8bX1dvao4jfj/view?usp=share_link


...more
View all episodesView all episodes
Download on the App Store

The Genetics PodcastBy Sano Genetics

  • 4.8
  • 4.8
  • 4.8
  • 4.8
  • 4.8

4.8

43 ratings


More shows like The Genetics Podcast

View all
Science Friday by Science Friday and WNYC Studios

Science Friday

6,133 Listeners

Nature Podcast by Springer Nature Limited

Nature Podcast

758 Listeners

Planet Money by NPR

Planet Money

30,845 Listeners

Freakonomics Radio by Freakonomics Radio + Stitcher

Freakonomics Radio

32,299 Listeners

TED Radio Hour by NPR

TED Radio Hour

22,089 Listeners

Hidden Brain by Hidden Brain, Shankar Vedantam

Hidden Brain

43,483 Listeners

Radio Atlantic by The Atlantic

Radio Atlantic

2,327 Listeners

The Readout Loud by STAT

The Readout Loud

318 Listeners

The Next Big Idea by Next Big Idea Club

The Next Big Idea

1,276 Listeners

Short Wave by NPR

Short Wave

6,273 Listeners

BioCentury This Week by BioCentury

BioCentury This Week

29 Listeners

People I (Mostly) Admire by Freakonomics Radio + Stitcher

People I (Mostly) Admire

2,134 Listeners

Biotech Hangout by Daphne Zohar, Josh Schimmer, Brad Loncar, Tim Opler & more

Biotech Hangout

18 Listeners

NEJM AI Grand Rounds by NEJM Group

NEJM AI Grand Rounds

54 Listeners

Ground Truths by Eric Topol

Ground Truths

51 Listeners