TWiM visits Tufts University School of Medcine and are joined by John Coffin, Michael Malamy, and Verna Manni for a tribute to Elio Schaechter who was chair of Molecular Biology and Microbiology for 23 years.

TWiM explains how Streptococcus mitis bacteriocins drive contact-dependent lysis of S. pneumoniae facilitating transformation, and microbial dominance in diabetic foot osteomyelitis determined with nanopore sequencing.

Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson

Subscribe to TWiM (free) on Apple Podcasts, Stitcher, RSS, or by email.

• Streptococcus mitis bacteriocins drive contact-dependent lysis of S. pneumoniae (mBio)
• Microbial dominance in diabetic foot osteomyelitis determined with nanopore sequencing (J Inf Dis)
• Diabetic foot ulcer review (World J Clin Cases)
• How nanopore sequencing works (YouTube)

Become a Patron of TWiM!

Music used on TWiM is by Ronald Jenkees.

Send your microbiology questions and comments to [email protected]

TWiM explains how an enhanced domestication method allows for growth of uncultured bacteria, and identification of the oncogene SLC35F2 as is a high-specificity transporter for the micronutrients queuine and queuosine.

Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson. Guest: Mark O. Martin

Become a patron of TWiM.

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

• Domestication method for uncultured bacteria (ISME Comm)
• Transporter for the micronutrients queuine and queuosine (PNAS)
• How diet and microbiome can impact your health (UF blog)
• Take the TWiM Listener survey!

Send your microbiology questions and comments (email or recorded audio) to [email protected]

TWiM explains a candidate signature of health in the gut microbial community, and how an intestinal bacterium exacerbates cardiac ischemia/reperfusion injury.

Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson and Petra Levin.

Become a patron of TWiM.

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

• A candidate signature of health in the gut microbiome (Cell Host Microbe)
• 204,938 reference genomes from the human gut microbiome (Nat Biotech)
• A human gut metagenome-assembled genome catalogue spanning 41 countries (Nat Micro)
• A comprehensive ruminant microbial catalog (Gigascience)
• Bacteroides acidifaciens exacerbates cardiac ischemia/reperfusion injury (Cell Host Microbe)
• The Great Ozempic Experiment (NY Times, paywall)
• Take the TWiM Listener survey!

Send your microbiology questions and comments (email or recorded audio) to [email protected]

TWiM explains how to use microbes to enhance maize yield and reduce corn rootworm damage, and how the human microbiota modulates IgE-mediated reactions to foods through allergen metabolism.

Hosts: Michael Schmidt, Petra Levin, and Michele Swanson.

Guest: Mark O. Martin

Become a patron of TWiM.

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

• Harnessing Microbes for Crop Production (Phytobiome J)
• Microbes take on corn rootworm (Science)
• Microbial metabolism of food allergens (Cell Host Microbe)
• Take the TWiM Listener survey!

Send your microbiology questions and comments (email or recorded audio) to [email protected]

TWiM reveals the archaeal roots of eukaryotic life, and a building a gut malabsorption biosensor with bacteria.

Become a patron of TWiM.

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

• The archaeal roots of eukaryotic life (PNAS)
• Building a malabsorption biosensor (Cell)
• Engineering gut biosensors with microbes (Nature)
• Take the TWiM Listener survey!

Send your microbiology questions and comments (email or recorded audio) to [email protected]

TWiM discusses the use of bacteriophage-loaded microneedle patches for targeted and minimally disruptive foodborne pathogen decontamination, and a conjugal gene drive-like system that efficiently suppresses antibiotic resistance in bacteria.

Become a patron of TWiM.

Links for this episode:

• Bacteriophage-loaded microneedle patches for food (Sci Adv)

• Gene drive to suppress antibiotic resistance (npj antimicrob and resistance)

• CRISPR gene drives (Syntego)

• Bier laboratory

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to [email protected]

Nancy and Maggie join TWiM to share how and why they created a freely available ebook of TWiM-based science literacy resources and classroom exercises that support teaching across key microbiology and molecular biology topics.

Become a patron of TWiM.

Links for this episode:

• Podcast annotation and resources in microbiology (Iowa State U)

• Curriculum guidelines for undergraduate microbiology (ASM)

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to [email protected]

TWiM explains how mechano-bactericidal surfaces made from diverse materials and patterned with spikes kill bacteria on contact, and virus-host evolution is reshaped by microgravity aboard the International Space Station.

Become a patron of TWiM.

Links for this episode:

• Mechano-Bactericidal Surfaces (Adv Sci)

• Piercing pathogens (ASM)

• Natural bactericidal surfaces (Small)

• Virus-host evolution in microgravity (PLoS Biol)

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to [email protected]

TWiM explains the finding that owning a dog during adolescence alters the microbiota and improves mental health, and the molecular basis for multidrug efflux by an anaerobic-associated resistance-nodulation-cell division transporter.

Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson and Petra Levin.

Become a patron of TWiM.

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

• Dog ownership and the microbiome during adolescence (iScience)
• Molecular basis for multidrug efflux (Nat Comm)
• Take the TWiM Listener survey!

Send your microbiology questions and comments (email or recorded audio) to [email protected]