Science In Action

Many coronaviruses exist in nature that we don’t know much about. We don’t even know how and whether most of them might bind to human cells. Research published in Nature, by scientists at Wuhan and Washington Universities, describes a new way of designing novel receptor sites on cell cultures so that many types of coronavirus may now be cultured and studied to ascertain their risk to humans. Cambridge virologist Ravindra Gupta, who is not one of the authors, gives Science in Action his take on the risks versus the reward.

Dotted around the remains of Pompeii, visitors are often struck by the plaster casts of some of the victims’ dying moments. During recent restoration of several of these casts, scientists were able to extract DNA samples from bones which had previously been enveloped by plaster since their initial discovery. As Alissa Mittnik of the Max Planck Institute for Evolutionary Anthropology describes, some of the findings confound our previous narratives about their lives, relationships, and even their genders.

Rozenn Pineau, a plant evolutionary geneticist at the University of Chicago in Illinois, has been investigating the unique evolutionary history of the world's oldest (and biggest) tree - "Pando".

And finally, the oldest known tadpole is described from a 160 million year old Argentinian fossil by biologist Mariana Chuliver.

Presented by Roland Pease

(Image: Illustration of Covid-19 coronavirus binding to human cell. Credit: Kateryna Kon via Getty Images)

This week at least 150 people have been killed due to devastating flash flooding sweeping through areas of Valencia in Spain. Ana Camarasa Belmonte, Professor of Physical Geography at the University of Valencia, has been studying the flood patterns and hydrology of the area for years. Even she was astounded by the magnitude of the inundation. And, as Jess Neumann of Reading University in the UK tells Roland, part of the tragedy is that the effective communication of risk somehow relies on citizens being able to adequately imagine the almost unimaginable.

Ten years ago this week, Friederike Otto and colleagues founded the World Weather Attribution network. The network aims to provide quick analysis of climate change's impact on on extreme weather events. They have already found that the Spanish flooding was made more intense, and more likely, by our warming world. Earlier in the week they published a different analysis of the 10 most deadly, extreme-weather events of this century. They concluded that all 10 events were made more extreme or more likely by climate change, and that these 10 events alone account for some 570,000 deaths.

In the US, Scientists have tested the strain of H5N1 bird flu swabbed from the eye of an infected Texan farm worker. They found it to be both lethal and transmissible via the respiratory tract of mice and ferrets. It contains a mutation PB2-627K, common in avian viruses in mammalian cells, as Amie Eisfeld of the Universoity of Wisconsin-Madison explains.

Presented by Roland Pease

(Image: Aftermath of catastrophic floods in Spain's Valencia. Credit: Anadolu via Getty Images)

Betelgeuse, one of the brightest and most famous stars in the northern night sky, has varied in brightness with an elusive pattern ever since observations began. Many theories exist as to why it ebbs and flows with apparently two distinct rhythms – one shorter and another around 2000 days long.

But just recently two independent astronomical teams have unveiled papers suggesting the existence of an orbital companion circling the red giant. About the size of our own sun, the “Betelbuddy” may whizz round Betelgeuse, almost skimming its surface, every 2000 days. And why haven’t we seen the Betelbuddy before? Because, from here, it would be a million times fainter than Betelgeuse itself, as one of the authors, and long-time Betelgeuse watcher, Andrea Dupree of Harvard and Smithsonian Centre for Astrophysics explains.

Back here on earth, Omar Yaghi of Berkeley, University of California and colleagues have been designing a new material that can scrub carbon dioxide out of the air in minutes. They have patented this type of Covalent Organic Framework (COF) and are hoping to scale up production such that a few hundred tonnes deployed around our biggest cities could solve our CO2 crisis.

But then what do you do with all those gigatonnes of CO2? Maybe one thing would be to use solar power to convert it into plant food. Robert Jinkerson and colleagues describe in the journal Joule a proposal to transform global food production into “Electro-Agriculture”, growing plants, fungi and algae on acetate made from solar energy. Their proposal would also shrink the global footprint of farming to allow more natural habitat.

And finally, Michael Frachetti of Washington University in St Louis has published an archaeological survey of two lost conurbations in the mountains of southern Uzbekistan that he and colleagues rediscovered in the last few years. He argues that the scale and complexity of these dwelling, and their location over 2000m, way above normal agricultural altitude mean we need to reconsider these stops on what would have been the Silk Road, around 600-1000 CE, perhaps even pointing at a very early industrial economy.

Presenter: Roland Pease

(Image: Orion sink to Kashimayarigadake. Credit: Getty)

The “dewilding” effects of fish farming and mariculture are in the spotlight this week. Farmed fish can impact marine ecosystems in several ways, and surprisingly one of those is the effect it has on consumer perceptions of the impact of eating farmed fish, as researchers Becca Franks of NYU and Laurie Sellars at Yale suggest.

Meanwhile, Manu Prakesh and colleagues at Stanford University in the US have found a remarkable plankton that can traverse the depths of the oceans by ballooning to five times its size, giving clues as to how an important carbon sink actually works. And Monika Bright at the University of Vienna has found animals and tubeworms living in the very rock below volcanic hydrothermal vents. Life finds a way…

…But not always. 445 million years ago the second worst mass extinction event wiped out countless species of life on earth. But why? This week astronomer Chrysa Avdellidou of Leicester University and colleagues say they have found the origin for a famous meteor event that also happened around that time.

Presenter: Roland Pease

(Image: Aerial view of seagulls following a fishing trawler. Credit: Felix Cesare via Getty Images)

In the week the Nobel prizes for science are announced, Roland Pease takes a look at the stories behind the breakthroughs being recognized, and the themes that connect them. From the discovery of the tiny fragments of RNA that regulate our cells’ behaviour, via computer structures that resemble our brains, and harnessing those sorts of computers to design drugs and medicines, it has been one of the most interdisciplinary years for the prize panellists.

We hear from old students, recent colleagues, laureates and lab (and life) partners, including Rosalind “Candy” Lee and her husband Victor Ambros, of UMass Chan Medical School, US, Erika DeBenedictus of the Crick Institute, UK, and Dmitri Krotov of IBM Research.

Presented: Roland Pease

(Photo: 3d rendering of RNA strands and lipid-based nanoparticles or liposome. Credit: Love Employee via Getty Images)

As we were putting the finishing touches to last week’s Science in Action, the US National Weather Service was warning of Hurricane Helene’s fast approach to the Florida coast – alerting people to ‘unsurvivable’ storm surges of up to 6 metres. But the category 4 storm powered, as forecast, far past the coast and into the rugged interior of Tennessee and the Carolinas. 150 billion tonnes of rainfall are estimated to have been dumped there, with devastating consequences for the towns and villages snuggled into the deep-cut valleys of the region. Bloomberg says the event could cost $160 billion. Extreme warmth in the Gulf of Mexico helped fuel the hurricane, and within a few days Berkeley climatologist Michael Wehner had computed the fingerprint of climate change on the event.

The journal Nature published this week a study estimating the true number of casualties of hurricanes like Helene – not just those registered in the immediate aftermath, deaths caused by the instant trauma, but those in the months, even years, that follow, because of the disruption to lives and infrastructure. Rachel Young of Stanford University was herself surprised by the scale of harm her calculations revealed.

At least the dams held in North Carolina during Helene, although the sight of torrents of water gushing down the protective spillways at the peak was fearsome to see. A year ago, the two dams upstream of the Libyan port Derna both failed during Storm Daniel – ripping out the heart of the city and claiming at least 6000 lives. We reported what we could at the time here on Science in Action. But a World Bank study on the disaster reported back to an international dam conference in India this week a more detailed investigation – though the fractious politics of Libya put constraints on their work. Climate change was a massive part – normal monthly September rain in the area is 1.5 mm – but over 200 mm, maybe 400, fell on the hills behind Derna the night of the 10th. But it was the report of independent engineer Ahmed Chraibi that interested Science in Action – on the condition of the two dams, one just on the edge of the city, the other larger one 15 km upstream. He confirmed these had been built, in the 70s, for flood protection not to store water, but were in a shocking state long before last year’s cataclysm.

You’ve not been paying attention here in the past 5 years if you haven’t learned how clever our immune system is in recognising viruses that invade our bodies. Different arms of the system like antibodies and white blood cells can take on the viruses directly, or kill infected cells to stop the infection spreading further. But it’s slow to respond to new infections, which is why our pharmacies also stock antivirals, small molecules which also lock onto components of viruses to stop them replicating. Too often though, they’re not as effective as we’d like. Flu antivirals for example work only if you catch the infection very early. So I was intrigued to read in the Proceedings of the National Academy this week of a new kind of drug that is like an antiviral, but gets the immune system to do the hard work. Imrul Shahria reckoned there are all kinds of antibodies and immune cells floating through our tissues not doing much, but that could be tricked into tackling flu infections – with a little molecular deception. He's effectively hacked the flu antiviral zanamivir which locks onto the neuraminidase protein – the N – of flu viruses, and given it immune superpowers.

Presenter: Roland Pease

(Photo: Hurricane Helene causes massive flooding across swaths of western North Carolina. Credit: Melissa Sue Gerrits/Getty Images)

Valerie Trouet of the University of Arizona tells us how tree-ring data has been used to show how the jet stream has shaped extreme weather in Europe for centuries, influencing harvests, wildfires and epidemics.

Monash University’s Andy Tomkins discusses how, around 460 million years ago, the Earth was briefly encircled by a ring of dust – like Saturn is today, and that the resulting temporary astronomical shade may have cooled the planet. Andy proposes that this dust came from an asteroid which had a close encounter with our planet.

And the cell biology of choking on your drink with Laura Seeholzer from the University of California, San Francisco. Laura has won the 2024 Eppendorf & Science Prize for Neurobiology recognising her work on the discovery of how neuroendocrine cells protect our airways.

Presenter: Roland Pease

(Photo: Members of the research team collected tree ring samples at various locations in Europe, including the Balkan region. Credit: Courtesy of Valerie Trouet)

The Sahara Desert has been experiencing unusually heavy rainfall due to an extratropical cyclone, causing flash floods in Morocco. We hear from Moshe Armon of the Hebrew University of Jerusalem.

A 485-million-year temperature record of Earth reveals Phanerozoic climate variability. Brian Huber of the Smithsonian National Museum of Natural History in Washington DC tells us more.

And Mary Lewis of Reading University discusses new research looking into what puberty was like for our ancestors towards the end of the last ice age. Teenagers from 25,000 years ago went through similar puberty stages as modern-day adolescents.

Presenter: Roland Pease

(Photo: Moroccan municipal workers and members of Auxiliary Forces help drain a road in a flooded neighbourhood in the city of Ouarzazate. Credit: Abderahim Elbcir/AFP/Getty Images)

Nearly a year ago, the top of a mountain on the Greenland coast broke off and slid a thousand metres down into the Dickson Fjord. The impact created a tsunami that started two-hundred-metres-high and sloshed between the cliffs for nine days, producing a global seismic signal. But it was so remote, only now are the details becoming clear. We hear from Paula Koelemeijer, Wieter Boone and Søren Rysgaard.

The decline of the ancient inhabitants of Rapa Nui was unlikely to have been caused by a self-inflicted population collapse, thereby rejecting a contentious theory of ‘ecological suicide’. Anna-Sapfo Malaspinas of the University of Lausanne discusses her team’s findings which shed light on the population history of the island formerly known as Easter Island - one of the most remote inhabited places in the world, around 3,700 km west of South America and over 1,900 km east of the closest inhabited island.

A newly identified species of wasp that attacks and lays eggs inside an adult fly has been discovered by Logan Moore and colleagues from Mississippi State University. Around 200 species of parasitoid wasps that target the fruit fly have been discovered to date - they lay their eggs in living creatures - all of which have been shown to target their hosts during vulnerable stages, such as when larvae or pupae. Until now, no wasp that attacks and develops inside the adult stage of a fruit fly host has been described.

Presenter: Roland Pease

(Image: Copernicus Sentinel Data (2023). Credit: European Space Agency)

A Chinese survey of diseased animals farmed for their fur – such as mink, foxes and raccoon dogs - has revealed high levels of concerning viruses, including coronaviruses and flu viruses, many of which appear to jump easily from species to species. John Pettersson of Uppsala University discusses the threat to us humans.

We learnt early on in the Covid-19 pandemic how important the genetic details of the virus were in tracking the spread and spotting new variants. The vaccines were designed from gene sequences shared electronically long before any biological samples became available. Virologist Emma Hodcroft has teamed up with researchers around the world to develop a new virus database, Pathoplexus, to speed up the sharing of gene sequences.

Mpox outbreaks are causing concerns in Central and West Africa - particularly in the Democratic Republic of the Congo. A smallpox vaccine has started arriving, giving some protection against mpox. But there’s good news this week in an experimental vaccine developed especially for mpox by Moderna – one of the companies that brought us the mRNA vaccines against Covid-19. Galit Alter, vice president of immunology research at Moderna, tells us animal tests show that it appears to be highly effective.

And we discuss embryonic eavesdropping with Francisco Ruiz-Raya of Glasgow University. In the yellow-legged-gull, baby bird embryos that have chattier parents tend to come out chattier themselves – and likely receive better care because of their enhanced communication.

Presenter: Roland Pease

(Image: A mink in a mink farm in the hands of a man. Credit: Neznam/Getty Images)