In this special celebratory 100th episode, I discuss six major unsolved problems in science: the P vs NP problem in computer science, the mystery of dark matter in physics, the existence of the island of stability in chemistry, the historical occurrence of a snowball Earth scenario from geology, the protein folding problem from biochemistry, and the origin of the Cambrian explosion in evolutionary biology. I also discuss some important ideas relating to the future of the podcast.

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