“Knowledge is power,” said Sally Hughes, who was treated for endometrial cancer at the OSUCCC – James and was a participant in the Ohio Prevention and Treatment of Endometrial Cancer (OPTEC), a statewide program funded by Pelotonia. In this episode, Hughes and David Cohn, MD, the chief medical officer of the James, discuss the ongoing impact of OPTEC. In the program, women diagnosed with endometrial cancer were screened to determine if they had Lynch Syndrome, an inherited genetic mutation that greatly increases the risk for colorectal and endometrial cancer. Family members of the women who tested positive for Lynch Syndrome were then screened. “This is called cascade testing and it saves lives,” Cohn said. While Hughes did not have Lynch Syndrome, which meant her children could not have it, she tested positive for a different genetic mutation that increases her risk of breast cancer. “Because of this and my family history [of cancer], I’m now in the High-Risk Breast Cancer Program,” she said. “I go in every six months for a mammogram or MRI.” Hughes also describes how she has become an advocate for increased funding for cancer research and reducing health disparities, and she is an active member of the James Ambassadors Society and a Pelotonia rider. “Cancer had a silver lining for me,” she said. “It gave me clarity about how I want to spend the next chapter of my life.”