This is a research article describing a randomized trial comparing two different strategies for vascular access closure after transfemoral transcatheter aortic valve implantation (TF-TAVI), a procedure used to treat patients with severe aortic valve stenosis. The primary endpoint of the study was a composite of major or minor access site-related vascular complications during index hospitalization, with the study demonstrating that a combined suture-/plug-based vascular closure device (VCD) strategy was significantly superior to a suture-based VCD strategy. The study also found that the combined strategy was associated with shorter time to hemostasis and a lower rate of bleeding events compared to the suture-only approach. The researchers conclude that the combined strategy represents a promising option for vascular access closure after TF-TAVI.