As a boy, Tyler Hubby began making films and photographs. While in high school, he was mentored by then unknown director David Fincher. Later on, Tyler went on to study film and photography at the San Francisco Art Institute with "low-fi" underground film legend George Kuchar.

His subversive and irreverent short films and videos detailing fetishism, co-dependency and bodily mutations have screened internationally, and are featured in Jack Sargeant's book Cinema Contra Cinema.

Tyler has documented artists such as Faust, Keiji Haino, John Fahey, Jim O'Rourke, Rhys Chatham, Arnold Dreyblatt, Zeena Parkins, Jonathan Kane and Tony Conrad. Furthermore, he has edited over 30 documentary films. Most notable among them are The Devil and Daniel Johnston, a biography of mentally ill artist/musician Daniel Johnston; The Final Member which follows the curator of the Icelandic Phallological Museum as he attempts to complete his exotic penis collection; The Great Invisible, which won the Grand Jury Prize at SXSW 2014. Tyler also served as an additional editor on the Oscar nominated Roman Polanski: Wanted and Desired.

Tyler wrote and directed Tony Conrad: Completely in the Present, a feature documentary about iconoclastic multi-media artist Tony Conrad that was named as one the best films of 2017 by Artforum.