In today’s episode Jeremy and Sass start by diving into normal physiologic function of the Hypothalamic-Pituitary-Adrenal (HPA) Axis. They then review how it’s regulated and the pathology/medications that can alter the HPA Axis. After that, it’s all about the adrenal glands, and Jeremy and Sass differentiate between Acute Adrenal Crisis and Adrenal Insufficiency. They talk about why chronic steroid use puts patients at risk for Adrenal Crisis and why cortisol is necessary for proper cardiovascular function and a whole lot more. This is definitely the nuts and bolts of “What you need to know”!

References

1. Bruder EA, Ball IM, Pickett W. 2015. Single induction dose of etomidate versus other induction agents for endotracheal intubation in critically ill patients. Cochrane Database Syst Rev. doi 10.1002/14651858. 

2. Chabre O, et al. 2017. Epidemiology of primary and secondary adrenal insufficiency. Ann Endocrinol. 78(6):490-494.

3. Liu M., 2017. Perioperative steroid management. Anesthesiology, 127(1), 166-172.

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Music by Alex Grohl