In Episode 15 of the Nurse Anesthesia Podcast, Jeremy and Sass dive into the pharmacological world of ketamine. They talk about all the anesthesia situations where it can be useful. They discuss the pharmacology of ketamine, appropriate dosing, what the current evidence really shows about its use with increased intracranial pressure, and how it is frequently used for analgesia. It really is the Swiss army knife of anesthetic meds!
References

1. Aleksandrova LR, et al. Antidepressant effects of ketamine and the roles of AMPA glutamate receptors and other mechanisms beyond NMDA receptor antagonism. J Psychiatry Neurosci. 2017 Jul; 42(4): 222–229. 
2. Bar-JosephG, et al. Effectiveness of Ketamine in Decreasing Intracranial Pressure in Children With Intracranial Hypertension. J Neurosurg Pediatr. 2009 Jul;4(1):40-6. 
3. Farrell A, Bendo D. Perioperative Management of Severe Traumatic Brain Injury: What Is New? Curr Anesthesiol Rep. 2018; 8(3): 279–289. 
4. Ghojazadeh M, et al. Using Ketamine and Propofol for Procedural Sedation of Adults in the Emergency Department: A Systematic Review and Meta-Analysis. Adv Pharm Bull. 2019 Feb;9(1):5-11.
5. Hashimoto K. Rapid‐acting antidepressant ketamine, its metabolites and other candidates: A historical overview and future perspective. Psychiatry Clin Neurosci. 2019 Oct; 73(10): 613–627. 
6. Jankauskas V, et al. A review of ketamine’s role in ECT and non-ECT settings
7. Neuropsychiatr Dis Treat. 2018; 14: 1437–1450. 
8. Liriano F, et al. Ketamine as treatment for post-traumatic stress disorder: a review. Drugs Context. 2019; 8: 212305. 
9. Merelman AH, et al. Alternatives to Rapid Sequence Intubation: Contemporary Airway Management with Ketamine. West J Emerg Med. 2019 May; 20(3): 466–471. 
10. Porter S. Perioperative ketamine for acute analgesia and beyond. Rom J Anaesth Intensive Care. 2019 Apr; 26(1): 67–73.  

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Music by Alex Grohl

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