Throughout much of U.S. history, anti-trust movements – joined by farmers, laborers, abolitionists, and small businesspeople – were a force to be reckoned with in American politics. Then, in the late 1970s, anti-monopoly fervor subsided and remained dormant for the next 40 years. The tides have now begun to change, with the appointment of leading anti-trust experts in to the Biden administration, and a growing number of labor and grassroots organizers once again taking aim at monopoly power. This history and the present urgency of anti-trust organizing is the subject of episode 22 of Reinventing Solidarity.