Space exploration thrills kids and adults alike. Today I discuss the history of NASA and space science with Pam Melroy. Pam piloted the Space Shuttle missions STS-92 in 2000 and STS-112 in 2002, and she commanded STS-120 in 2007. We discuss the Mercury, Gemini, Apollo and Apollo-Soyuz programs, the Mariner 9 mission, Landsat satellites, Skylab, the Space shuttle, and the International Space Station. We also discuss scientific advances achieved in space in telemedicine, microgravity and health, protein crystal growth and drug development, and materials science, as well as the future of space science.