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Hi everyone,
I’m delighted to have on molecular biologist and fellow freedom fighter on the podcast today. In this conversation, we discuss a new Nature paper that highlights the potential problems with the modified mRNA used in the COVID-19 vaccines. Dr. Rose explain the process of mRNA and protein translation, as well as the role of codon optimization. The conversation delves into the implications of N1-methyl pseudouridine and frame shifting, which can lead to the production of unintended proteins. We also discuss the unpredictability of dosing and the need for further research to understand the potential risks associated with the modified mRNA vaccines.
Chapters
00:00 Introduction and Background
07:05 Discussion on COVID Work
08:34 Introduction to the Nature Paper
09:01 mRNA and Protein Translation
13:25 Modified mRNA and Protein Production
29:24 N1-methyl Pseudouridine and Frame Shifting
36:05 Discussion on the Nature Paper
45:37 Implications and Unknowns
52:04 Predictability and Dosing
53:01 Codon Optimization and Slippery Sequences
54:56 Codon Optimization and Protein Production
55:54 Implications of Increasing GC Content
56:49 Ribosomal Pausing and Frame Shifting
59:08 Co-Translational Folding
01:00:06 The Potential of the mRNA Platform
01:01:31 The Complexity of the Human Body
01:03:17 Safety and Regulatory Considerations
01:05:40 Challenges of Coding Different Proteins
01:07:01 The Need for Regulatory Processes
01:09:21 Takeaways and Implications
By Dr. Jay Bhattacharya & Rav Arora4.8
185185 ratings
Hi everyone,
I’m delighted to have on molecular biologist and fellow freedom fighter on the podcast today. In this conversation, we discuss a new Nature paper that highlights the potential problems with the modified mRNA used in the COVID-19 vaccines. Dr. Rose explain the process of mRNA and protein translation, as well as the role of codon optimization. The conversation delves into the implications of N1-methyl pseudouridine and frame shifting, which can lead to the production of unintended proteins. We also discuss the unpredictability of dosing and the need for further research to understand the potential risks associated with the modified mRNA vaccines.
Chapters
00:00 Introduction and Background
07:05 Discussion on COVID Work
08:34 Introduction to the Nature Paper
09:01 mRNA and Protein Translation
13:25 Modified mRNA and Protein Production
29:24 N1-methyl Pseudouridine and Frame Shifting
36:05 Discussion on the Nature Paper
45:37 Implications and Unknowns
52:04 Predictability and Dosing
53:01 Codon Optimization and Slippery Sequences
54:56 Codon Optimization and Protein Production
55:54 Implications of Increasing GC Content
56:49 Ribosomal Pausing and Frame Shifting
59:08 Co-Translational Folding
01:00:06 The Potential of the mRNA Platform
01:01:31 The Complexity of the Human Body
01:03:17 Safety and Regulatory Considerations
01:05:40 Challenges of Coding Different Proteins
01:07:01 The Need for Regulatory Processes
01:09:21 Takeaways and Implications

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