In this week’s episode, we explore the evolving role of ketamine in clinical practice—from its antidepressant effects in treatment-resistant depression to its potential use in opioid use disorder. But therapeutic promise comes with toxicologic concerns. We take a closer look at the consequences of chronic ketamine use, including ketamine use disorder, cognitive and urinary complications, and the broader impact on mental and physical health. Join us as we unpack the science, the risks, and the delicate balance between benefit and harm.

Hope you enjoy!

Links to the papers we discussed:

https://pmc.ncbi.nlm.nih.gov/articles/PMC12040862/

https://www.tandfonline.com/doi/full/10.1080/10826084.2025.2497950?needAccess=true

https://onlinelibrary.wiley.com/doi/10.1111/add.70073

Disclaimer: All opinions are our own.

Find us on instagram: @the_tox_lab

Email us here: [email protected]