The provided text offers a comprehensive overview of cardiac rehabilitation (CR), tracing its evolution from a post-myocardial infarction mobilization strategy to a multidisciplinary program for diverse cardiovascular disease (CVD) patients. It examines the physiological mechanisms of weakness and functional decline in CVD, emphasizing impairments in cardiac output, vascular function, and skeletal muscle metabolism. The sources also discuss rehabilitation strategiesacross various settings, including intensive care units, hospital wards, and outpatient programs, highlighting the importance of early mobilization and tailored exercise prescriptions. Finally, the text explores emerging and adjunctive therapies, such as combined nutrition and rehabilitation, pharmacological interventions, and novel digital health technologies, all aimed at optimizing patient outcomes and addressing barriers to CR participation.