This review article explores the brain-heart axis, a complex network of interactions between the neural and cardiovascular systems crucial for maintaining bodily equilibrium. It highlights how dysfunction in this axis can lead to various neurological and cardiovascular disorders. The authors identify three primary interacting pathways: the neural pathway, involving the autonomic nervous system and central autonomic network; the mechanical pathway, which focuses on mechanoreceptors like Piezo proteins detecting blood pressure changes; and the biochemical pathway, mediated by various endogenous compounds. The article emphasizes the importance of an integrative, multisystem approach, advocating for the emergence of neurocardiology as a specialized clinical field.