This week, we’re talking about the toxic combination of cocaine and alcohol. We explore the formation of cocaethylene, and the role both cocaine and cocaethylene play in arrhythmias and other cardiac complications. We also examine potential mechanisms of liver injury linked to cocaine use—and how alcohol may amplify this effect.

Join us as we break down the pharmacology and clinical consequences of this high-risk pairing.

Hope you enjoy!

Links to the papers we discussed:

https://academic.oup.com/jat/article-abstract/43/3/155/5363995?redirectedFrom=fulltext

https://www.mdpi.com/2077-0383/13/5/1475

https://link.springer.com/article/10.1007/s10565-024-09901-5

Disclaimer: All opinions are our own.

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