She sets the stage with the start of the Gold Rush and how settlers wiped 2/3 of native peoples off the census of California within two years. Then shares how one feared tribe, the Yahi fought to survive. On Aug. 29, 1911, a starving middle-aged man, walks onto the pages of written history as the last member of his tribe. 

After he dies, his wishes for his body are ignored and spark a lengthy court battle as several indigenous tribes fight to unite his brain and body and give him the last rites he deserves. 

This episode pairs well with: 

Sacagawea and her mysterious death(s)