Here is the first of a series of Q&A podcasts on ESVS clinical practice guidelines. We start with the ESVS 2023 Clinical Practice Guidelines on Antithrombotic Therapy for Vascular Diseases, and, in this first release, Prof. Chris Twine clarifies the evidence underlying some recommendations on antithrombotic therapy in carotid artery disease. Key for our everyday clinical practice, don't miss it!