Transboundary animal diseases pose a continual threat to the health of livestock and the welfare of livestock producers, with foot-and-mouth disease and similar transboundary (FAST) animal diseases (including peste des petits ruminants, Rift Valley fever, and capripoxvirus diseases) being of exceptional concern. The role of wildlife in maintaining or propagating these diseases is an area of active research, and should epidemic incursions occur into formerly disease-free regions, achieving disease control can require measures targeting both the domestic and the wild compartments. Understanding how transmission dynamics and applied control measures in one compartment can influence dynamics in the other compartment may be key to enacting optimal strategies, and parameterized models that account for this interface could play an important role in such decisions. Using the current African swine fever pandemic as a case study, we’ve created a model to mechanistically explain these transmission dynamics in an environment with suspected disease spillover.