Today, I am thrilled to connect with Dr. Austin Perlmutter, a board-certified internal medicine physician, New York Times bestselling author, researcher, educator, podcaster, and entrepreneur. He is on a mission to help people get their brains unstuck for better mental and cognitive health. 

In our conversation today, we explore brain inflammation and its connection to longevity, the differences between acute and chronic inflammation, the influence of environmental factors, and how exposure to negative news and biases can elevate stress and affect our brain health. We examine how consumer culture promotes stress and disconnection, and we unpack the immune-metabolic effects of estrogen and its impact on neuroplasticity and our ability to learn. We also focus on the role of nutrition and nutraceuticals, and we discuss the relationship between the brain, gut, and the vagus nerve.

This discussion with Dr. Austin Perlmutter is rich and insightful, and I look forward to welcoming him back for further exploration into the science and research.

IN THIS EPISODE, YOU WILL LEARN:

Why brain inflammation becomes an issue for many women as they navigate middle age and beyond

How inflammation leads to constant changes in our cognitive and mental state

Various environmental factors and other inputs that could influence brain inflammation

Some easy ways to positively impact your brain health and cognition

How chronic stress affects the brain

How the gut microbiome and the gut immune system influence cognitive and mental health

The long-term health benefits of avoiding processed foods and following a Mediterranean diet 

The importance of being conscientious and purposeful about the quality of the foods you eat

Dr. Perlmutter shares easy and cost-effective ways to improve your cognitive, mental, and overall health

Bio:

Dr. Austin Perlmutter is a board-certified internal medicine physician, New York Times bestselling author, published researcher, and a leading expert on how lifestyle and environmental factors impact mental health. His mission is to help people reclaim their mental and physical health by addressing the biological basis of “stuckness” that disrupts brain function and emotional balance. He is a co-producer of the Alzheimer’s: The Science of Prevention series and the host of the Better Brain Blueprint series, where he provides actionable strategies to support brain resilience.

Dr. Perlmutter currently serves as the Managing Director at Big Bold Health, a food-as-medicine company focused on helping people rejuvenate health through better immune function, where he has published a pioneering study exploring the effects of plant nutrients on human aging through epigenetics.

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Connect with Dr. Austin Perlmutter

On his website

On social media: @draustinperlmutter

Find out more about the research on immuno-metabolism pathways 

Big Bold Health on social media: @bigboldhealth

We have the second episode in a series of conversations with Dr. Thomas Dayspring today. 

The esteemed Dr. Dayspring is an expert on internal medicine and clinical lipidology. In this episode, we continue with our last conversation, diving into Lp(a) and the influences of gender, race, and menopause. We explain how estrogen is a PCSK9 inhibitor and explore the significance of brain health and risks for dementia. We tackle cholesterol synthesis and discuss the side effects of statins, clarifying who is most susceptible to their impact on the brain. We also examine the significance of the desmosterol biomarker, highlighting the level to aim for, especially when making decisions regarding cholesterol medications, and we answer one question from a listener. 

You may want to listen to this insightful conversation with the renowned Dr. Dayspring more than once. He has graciously agreed to return and film additional episodes, where we will dive into more questions from listeners. 

IN THIS EPISODE, YOU WILL LEARN:

Why Lp(a) is like a wolf in sheep's clothing for many individuals

How Lp(a) levels are higher in African Americans and women, especially after menopause 

Dr. Dayspring highlights that Lp(a) particles are even more pro-inflammatory than LDL particles

How PCSK9 inhibitors are the only drugs that significantly reduce Lp(a)

Why do women have a higher risk of dementia than men?

Dr. Dayspring explains ApoE as the key lipoprotein for brain cholesterol transport.

How statins cross the blood-brain barrier to lower brain cholesterol

Why desmosterol levels matter

New therapies that can lower ApoB and Lp(a)

Why imaging is essential for menopausal women with elevated ApoB and Lp(a)

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Submit your questions to [email protected]

Connect with Dr. Thomas Dayspring

On X (@Drlipid)

On LinkedIn

Journal Article: Atherosclerosis: Non-genetic influences on lipoprotein(a) concentrations 

Journal of the American Heart Association: Trajectories of Blood Lipid Profiles in Midlife Women: Does Menopause Matter?

We have another episode in our series of sponsored podcasts today, with brands I like, know, and trust.

I am delighted to reconnect with Angelo Keely, the founder and CEO of Kion, a supplement company that focuses on helping people look good, feel young, and be strong.

In our discussion today, Angelo explains essential aminos, highlighting their importance and clarifying how to differentiate between various protein powders and other forms of protein. We explore the significance of bioavailability, anabolic resistance, and changes in body composition, discussing how protein needs increase with age and how dieting and caloric restriction can augment our protein requirements. We also cover the results of intermittent fasting, examining how sleep, stress, and lifestyle requirements can change with menopause.

I regularly take Kion essential amino acids. They have generously offered a discount for our community. Use the link in the show notes to get 20% off your next Kion purchase.

IN THIS EPISODE, YOU WILL LEARN:

The importance of eating sufficient protein as you age

How various protein sources, such as animal protein, plant protein, whey protein, and essential amino acids, differ

Strategies to buffer your protein intake and support your body as you navigate middle age and beyond

Why Leucine is vital for muscle protein synthesis

Why you should only source your amino acid supplements from trusted brands that follow the science

How much protein do you need to maintain your body composition as you age?

Why sleep is crucial for muscle protein synthesis

How supplementing with essential amino acids helps you maintain your muscle mass throughout your life  

The benefits of body scans for a better understanding of your body composition

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Submit your questions to [email protected]

Connect with Angelo Keely

Get a 20% discount on Kion products

I am deeply honored to reconnect with Dr. Thomas Dayspring, who joined me in 2024 for an immensely popular five-part series. Dr. Dayspring is certified in internal medicine and clinical lipidology. He is a distinguished fellow of both the American College of Physicians and the National Lipid Association. 

Today, we have the first episode in a new series of conversations with Dr. Dayspring, in which he will share more of his perspective and answer more questions from listeners. In our discussion, we review the basics about cholesterol, triglycerides, and lipoproteins, exploring the factors that contribute to the development of cardiovascular disease, the significance of ApoB and Lp(a), and the risk factors for younger women. We also dive into the limitations of traditional allopathic medicines, and Dr. Dayspring shares his views on lipids, lipid changes in menopause, specific ways to address ApoB, some of the challenges associated with statin therapy, and more. 

Dr. Dayspring brings a wealth of experience and expertise to this discussion, and you are sure to find this series as invaluable as the last.

IN THIS EPISODE, YOU WILL LEARN:

Dr. Dayspring revisits the differences between cholesterol, triglycerides, and lipoproteins

What atherosclerosis is, and why it is concerning

Dr. Dayspring explains the structure and function of lipoproteins

The role of ApoB in lipoprotein particles and its significance in atherosclerosis

Some of the risk factors for lipid abnormalities in younger women

Lipid changes that occur as women transition from perimenopause to menopause 

Dr. Dayspring shares his take on statin therapy

Ways to address high ApoB

Dr. Dayspring’s suggested goals for ApoB therapy

Connect with Cynthia Thurlow  

Follow on ⁠X⁠, ⁠Instagram⁠ & ⁠LinkedIn⁠

Check out Cynthia’s ⁠website⁠

Submit your questions to ⁠[email protected]⁠

Connect with Dr. Thomas Dayspring

On⁠ X⁠ (@Drlipid)

On⁠ LinkedIn⁠

⁠Journal Article: Atherosclerosis: Non-genetic influences on lipoprotein(a) concentrations⁠ 

⁠Journal of the American Heart Association: Trajectories of Blood Lipid Profiles in Midlife Women: Does Menopause Matter?⁠  

I am honored to connect with Mike Sapiro today. He is an ordained Zen Buddhist monk, poet, clinical psychologist, psychedelic psychotherapist, author, meditation teacher, and researcher, in addition to being a transformational coach for world-class musicians, athletes, veterans, scientists, authors, and playwrights.

In our conversation, Mike talks about truth medicine and explains how trauma is a disconnection from the present moment, clarifying how the nervous system responds to chronic stress or trauma, and how midlife transitions can reactivate unhealed wounds. We explore how culture, ancestry, parenting, and epigenetics shape conditioning, and examine the roles of ego, psychedelics, and surrender in the healing process. We also discuss what it means to lead with the heart, integrity, and humility, and tackle the emotional weight of regret, remorse, and shame. Mike also recommends some simple yet powerful daily practices to help us heal.

This conversation with Mike Sapiro is truly invaluable. I loved his book, Truth Medicine, and I know the wisdom in both the book and this episode will resonate deeply with many of you.

IN THIS EPISODE, YOU WILL LEARN:

The healing benefits of framing trauma as a disconnection from the present moment

Understanding and addressing the causes of undesirable behaviors, and addressing the hurt and conditioning that drive them

How chronic stress and trauma impact the nervous system

How societal pressures and constant connectivity contribute to stress and a sense of disconnection

The value of psychedelics for accessing new perspectives and insights

How midlife transitions can reactivate unhealed wounds

The benefit of involving the heart, psyche, and cosmos in the therapeutic process

Why trusting, letting go, and surrendering are essential for psychedelic therapy 

How integrity and humility can lead to profound healing and transformation within the therapeutic process

Mike shares some small, consistent actions that can help build trust and self-care 

Bio:

Michael Ryoshin Sapiro, PsyD, is an ordained Zen Buddhist monk and poet, clinical psychologist, psychedelic psychotherapist, author, meditation teacher, and researcher. He is also a transformational coach for world-class musicians, athletes, former special operations veterans, scientists, CEOs, authors, and playwrights. 

Over the last two decades, he has served and reached thousands of people in a variety of settings: therapy, workshops, international retreats, hosting a nationally syndicated radio show called Radio Awakened, keynote addresses, and being featured on podcasts. In the last several years, his work has been featured on over 20 well-known podcasts, and he is a co-host for global mental health summits put on by Wisdom for Life, landing in over 70 countries and reaching hundreds of thousands of people. He is featured in a documentary by Brandow Kapelow called “An Act of Service” on ketamine treatment for first responders that was featured by The New York Times. He currently works extensively with first responders in therapy, offering ketamine-assisted psychotherapy, leading retreats, and running calls with them. He believes that unconditional love, speaking one’s truth, and authenticity are the medicines for good health and a thriving life. His work is dedicated to personal awakening for the sake of collective transformation. 

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Submit your questions to [email protected]

Connect with Dr. Michael Sapiro

On his website

On Instagram

Purchase a copy of Truth Medicine

I am delighted to have the privilege of reconnecting with Dr. Deb Matthew today. She joined me once before in Episode 259. She is a distinguished best-selling author, international speaker, and dedicated educator known as the Happy Hormone Doctor. 

Cardiovascular disease is the number one killer of women in the United States, causing one of every 3.2 deaths among women annually. In our conversation today, Dr. Matthew and I delve into the realm of cardiovascular disease, exploring the benefits of hormone replacement therapy, essential laboratory testing, medications, and the neurocognitive changes that occur during perimenopause and menopause. We also focus on lifestyle, gut testing, and the all-time favorite topic of weight loss resistance. 

Stay tuned for today’s engaging, enriching, and enlightening discussion with Dr. Deb Matthew.

IN THIS EPISODE YOU WILL LEARN:

 Connect with Cynthia Thurlow

Connect with Dr. Deb Matthew

Dr. Deb Mathew’s book ⁠This is Not Normal on Amazon⁠ or ⁠download the ebook⁠ 

Previous Episode featuring Dr. Matthew

⁠Ep. 295: HRT’s Impact on Women’s Health Through Time with Dr. Deb Matthew

Today, I have the honor of reconnecting with Dr. Vonda Wright, a renowned expert in Aging and Longevity with over 20 years of experience in orthopedic surgery and sports medicine. She is also the host of the Hot for Your Health podcast. 

In our discussion, we examine how mainstream news relies on sedentary science, highlighting the hallmarks of aging and the value of shifting mindsets around aging. We explore the foundational role of mitochondria in cellular health changes as we navigate the aging process, looking at satellite cells and the communication between muscle, bone, and adipose tissue. We also discuss the musculoskeletal syndrome in menopause, VO2 Max, and the science and lab testing that can help predict longevity and peak performance.

This conversation with Dr. Vonda Wright is truly invaluable, and I highly recommend her book, Unbroken, as a powerful resource for understanding the transition from perimenopause to menopause.

IN THIS EPISODE, YOU WILL LEARN:

Vonda explains how mainstream news is based on sedentary science 

How hormonal changes impact muscle quality during the perimenopause to menopause transition

Why exercise is essential for rejuvenating muscle stem cells and maintaining muscle mass as we age 

How satellite cells can lose their regenerative capacity through inactivity

Why exercise is necessary for producing Klotho (the longevity protein) 

How your muscles, bones, and fat are in constant communication

The benefit of VO2 Max for understanding how your current level of fitness will project into the future

The importance of knowing your longevity goals for creating a balanced fitness plan 

Knowing the difference between being lean and being healthy

Why muscle mass is crucial for your health and mobility

The specialty labs Dr. Vonda uses in her practice

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Submit your questions to [email protected]

Connect with Dr. Vonda Wright

On her website 

Instagram and YouTube

Dr. Wright’s book, Unbreakable, will come out on the 26th of August. You can pre-order a copy and get your Unbreakable Data Assessment App here.

We have the first episode in a series of thyroid-focused podcasts today.

In this episode, Dr. Anshul Gupta, Dr. Carrie Jones, and McCall McPherson join me to explore why Hashimoto’s tends to become problematic for women during perimenopause and menopause, and the root causes that drive it. We explore molecular mimicry, the effects of heavy metals, mycotoxins, mold, and other toxins on the thyroid, and explain how perimenopause impacts thyroid gland and immune system function. We cover non-thyroidal illness syndrome and cellular hypothyroidism, also focusing on Graves’ disease, which is due to a hyperactive thyroid gland, highlighting the standard of care it receives, preferred medications, and low-dose naltrexone.

Dr. Anshul Gupta explains why so many women with thyroid issues are unknowingly living with Hashimoto’s. He outlines the five root causes of Hashimoto’s, especially during perimenopause and menopause, highlighting the importance of addressing the underlying autoimmune process rather than simply replacing hormones. 

Dr. Carrie Jones explains why thyroid dysfunction in women often emerges during major hormonal transitions like perimenopause. She also points out that many cases of hypothyroidism involve issues that we cannot resolve with medication alone.

McCall McPherson discusses the challenges of diagnosing and treating Graves’ disease, which is often overlooked or mistaken for psychiatric issues. She explains the importance of proper testing, sharing some therapeutic approaches that can help stabilize thyroid function and calm the immune system.

You will not want to miss this invaluable compilation of powerful insights from three leading thyroid health experts.

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Connect with Dr. Anshul Gupta

On his website

YouTube and other social media (@AnshulGuptaMD)

Connect with Dr. Carrie Jones

On her website

Facebook, Instagram, and TikTok

Connect with McCall McPherson

Modern Thyroid Clinic

On Instagram and TikTok

Modern Thyroid and Wellness Podcast

Thyroid Lab Guide

Ep. 267 Hashimoto's: What Is It and How It Impacts Our Health with Dr. Anshul Gupta

Ep 241 Mitochondria, and the impact of hormone imbalances in perimenopause and menopause with Dr. Carrie Jones

Ep. 282 Thyroid Health: Hormones, Medications & Weight Loss with McCall McPherson

Today, we have another episode in our series of thoughtfully curated companies. This episode is sponsored by OneSkin, a company founded and led by an all-female team of PhD-level scientists. OneSkin is redefining how we think about aging, starting with the skin, our largest organ.

I am delighted to introduce Dr. Alessandra Zonari as our guest today. Dr. Zonari is far from your typical scientist. She is a true visionary with a passion for longevity, skin regeneration, and an occasional karaoke jam. With degrees in biology and stem cell biology and a doctorate in skin regeneration and tissue engineering, Dr. Zonari brings a wealth of knowledge and a fresh perspective to our conversation today.

Join us to learn more about OneSkin and how their products can reverse the effects of biological aging, helping your skin become stronger and more resilient as you age.

IN THIS EPISODE YOU WILL LEARN:

Dr. Zonari shares her mission to understand how skin can age healthier and stronger and reduce the risk of inflammation and diseases. 

How the female-led research team at OneSkin brings a unique perspective to skincare

How the OneSkin peptide can reverse 2.5 years of biological aging in just five days

The unique way in which they test their products and measure biological aging at OneSkin 

How estradiol loss during menopause exacerbates the accumulation of senescent cells and causes inflammation

Some common misconceptions about skincare for women in perimenopause and menopause

How lifestyle choices influence the aging process of the skin 

Why we must protect the skin from environmental stressors to slow the aging process 

How your skin cells can get reprogrammed to return to a youthful state

How OneSkin developed a hair care line to address hair loss and thinning

The importance of self-love and nourishing your body 

ABOUT OneSkin: 

Founded and led by an all-woman team of PhD-level scientists, OneSkin is transforming the way we think about aging, starting with the body’s largest organ, the skin. Our proprietary OS-01 (oh ess one) peptide is the first ingredient to reverse the biological age of skin by targeting cellular senescence, a key driver of aging. By targeting cellular senescence, the OS-01 peptide switches off the damaged cells that contribute to lines, wrinkles, and sagging skin. The result? Skin that looks and behaves younger. Our products are designed for young and mature skin, because it is never too early or too late to invest in your skin health! We create next-level skin care.

BIO: Alessandra Zonari, PhD, OneSkin Co-Founder & CSO

Alessandra is not your typical scientist. She is a visionary with a passion for longevity, skin regeneration, and the occasional karaoke jam. Growing up in a close-knit family in Brazil, Alessandra saw her grandparents struggle with age-related diseases, and she soon became fascinated by the possibility of using stem cells to redefine the aging process. After earning degrees in biology and stem cell biology and a doctorate in skin regeneration and tissue engineering, Alessandra joined OneSkin in 2017 as a founding member and Chief Scientific Officer. Her contributions include 20+ papers, three patents, and the development of their proprietary OS-01 peptide.

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Follow on ⁠X⁠

⁠Instagram⁠ & ⁠LinkedIn⁠

Check out Cynthia’s ⁠website⁠

Submit your questions to ⁠[email protected]⁠

Connect with Dr. Alessandra Zonari

On the ONESKIN⁠ website⁠

ONESKIN on⁠ Instagram⁠

Interested in trying OneSkin for yourself? Visit⁠ oneskin.co/CYNTHIA⁠ and use code CYNTHIA for 15% off your first purchase!

Today, I am delighted to reconnect with Dr. Tyna Moore. She is a naturopathic physician and chiropractor, in addition to being the host of the wildly popular Dr. Tyna podcast, a bestselling author, and an international speaker offering a unique perspective for those seeking a stronger foundation for their health and well-being. 

In our discussion today, we dive into the importance of strength training, exploring concerns about under-fueling our bodies, and the damaging messages women currently receive about food, body size, and exercise, particularly from the health and wellness community. Dr. Tyna discusses the signs she often sees in women who underfuel their bodies, explaining how underfueling affects key hormones, including cortisol, thyroid, progesterone, estrogen, and testosterone, and the value of strength training. We also explore medications that impact bone health, including SSRIs, hormones, peptides, exosomes, and stem cells. 

You will not want to miss this delightfully engaging and enlightening conversation with Dr. Tyna Moore.

IN THIS EPISODE, YOU WILL LEARN:

Why building muscle mass is essential for avoiding frailty in later life.

The cardinal signs of health and vitality for women, as we age

Why disordered eating and fear of strength training are common issues among women

Dr. Tyna shares her concerns about using GLP-1s for rapid weight loss.

The importance of eating enough food to fuel the muscles you are trying to build

Why a healthy body fat percentage, strength, mobility, good sleep, and reduced pain are far more important than appearance-based goals

How not eating enough can worsen hormonal dysregulation, and how long-term use of SSRIs can significantly increase the risk of osteoporosis.

Ways to regulate your hunger and prevent overeating at night

The value of doing strength training a few times a week to optimize your central nervous system

How peptides, exosomes, and stem cells can be beneficial- but only once you have optimized your lifestyle and foundational health

Bio:

Dr. Tyna Moore, ND, DC, is a leading expert in holistic regenerative medicine and metabolic resilience, with nearly three decades of experience in the regenerative medicine space. Traditionally and alternatively trained in both science and medicine, she brings a metabolic-first perspective to optimizing health from the ground up.

Dr. Moore is the host of The Dr. Tyna Show podcast and an international speaker known for her direct, no-nonsense approach to strength, hormones, and longevity. With a combined following of over half a million across platforms, she has been featured on dozens of top health podcasts and stages worldwide. Through her online education programs and social media presence, Dr. Moore helps the general public and practitioners get the basics right – because without a strong metabolic foundation, no therapy, treatment, or supplement will ever deliver lasting results.

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Connect with Dr. Tyna Moore

On her website

The Dr. Tyna Show

YouTube

Instagram